Article
Oncology
Dev Karan, Manohar Singh, Seema Dubey, Peter J. Van Veldhuizen, Yogen Saunthararajah
Summary: In this study, the unique role of guadecitabine (gDEC) in activating lysine methyl-transferases (KMTs) and its association with prostate cancer inhibition was described. It was found that gDEC upregulated epigenetic activating enzymes and contributed to the overall change in prostate cancer phenotype and anticancer effect independent of apoptosis. Mechanistically, gDEC increased the methylation of H3K4 in prostate cancer cell lines by depleting DNMT1. This study highlights the therapeutic potential of gDEC in reversing aberrant epigenetic repression and treating prostate cancer.
Article
Biochemistry & Molecular Biology
Runsheng He, Besa Xhabija, Lijin K. Gopi, Jiji T. Kurup, Zhishan Xu, Zhe Liu, Benjamin L. Kidder
Summary: The H3K4 demethylase KDM5B is overexpressed in various cancers and its high expression is associated with reduced survival. Loss of KDM5B in cancer cells leads to increased proliferation and expression of cancer stem cell markers. KDM5B also plays a role in regulating epigenetic plasticity, leading to changes in chromatin states and activation or repression of alternative transcriptional programs.
Article
Multidisciplinary Sciences
Yuqiu Wang, Yangyang Fan, De Fan, Yubo Zhang, Xiaoli Zhou, Ruikai Zhang, Yao Wang, Yujie Sun, Wei Zhang, Yuehui He, Xing Wang Deng, Danmeng Zhu
Summary: In this study, a plant-specific component of the DREAM complex called BTE1 was identified. It was found that the DREAM complex containing BTE1 acts against the COMPASS-like complex to repress transcription and occupancy of H3K4me3 at target genes. BTE1 was shown to interact with WDR5A, inhibiting its chromatin binding and transcription elongation on DREAM target genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Alvaro Gutierrez, Hannah Demond, Priscilla Brebi, Carmen Gloria Ili
Summary: Colorectal cancer is the third most common cancer globally, and biomarkers play a crucial role in diagnosis and predicting metastasis. Key signaling pathways associated with cancer progression include the MAPK pathway, p53 pathway, and TGF-beta pathway.
Article
Biochemistry & Molecular Biology
Yaxuan Wang, Xiaolin Wang
Summary: This study investigated the involvement of HSP90B1 in various cancers and found that it plays a significant role in tumor development and prognosis.
Article
Endocrinology & Metabolism
Jian Zhang, Huali Jiang, Kunpeng Du, Tao Xie, Baiyao Wang, Chengcong Chen, Russel J. Reiter, Bohong Cen, Yawei Yuan
Summary: Melatonin plays protective roles in cancer, and this study revealed the genomic alteration and clinical characteristics of melatonergic regulators in 33 cancers. Methylation-mediated downregulation of melatonergic regulator expression and the association with patient survival prediction were identified. A miRNA-mRNA interaction network involved in melatonin secretion and metabolism, as well as pathways related to inhibition of apoptosis, DNA damage response, cell cycle, and signaling activation, were also uncovered.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Biology
Kanishk Jain, Matthew R. Marunde, Jonathan M. Burg, Susan L. Gloor, Faith M. Joseph, Karl F. Poncha, Zachary B. Gillespie, Keli L. Rodriguez, Irina K. Popova, Nathan W. Hall, Anup Vaidya, Sarah A. Howard, Hailey F. Taylor, Laylo Mukhsinova, Ugochi C. Onuoha, Emily F. Patteson, Spencer W. Cooke, Bethany C. Taylor, Ellen N. Weinzapfel, Marcus A. Cheek, Matthew J. Meiners, Geoffrey C. Fox, Kevin E. W. Namitz, Martis W. Cowles, Krzysztof Krajewski, Zu-Wen Sun, Michael S. Cosgrove, Nicolas L. Young, Michael-Christopher Keogh, Brian D. Strahl
Summary: This study reveals that H3 tail acetylation promotes nucleosomal accessibility to H3K4 methyl readers and writers, resolving the long-standing question of why H3K4me3 levels are coupled with H3 acetylation.
Article
Multidisciplinary Sciences
Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch, Wilfred F. J. van Ijcken, Miguel Manzanares, Joanna Wysocka, Wolf Reikf, Alvaro Rada-Iglesias
Summary: The study reveals that partial retention of histone H3K4 monomethylation within relevant enhancers is crucial for germline competence and specification in in vitro differentiated primordial germ cells.Loss of this histone modification reduces the germline competence of EpiLC and decreases PGCLC differentiation efficiency, suggesting a key role in facilitating enhancer activation during specific developmental transitions.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Zijian Chen, Zenghong Huang, Yanxin Luo, Qi Zou, Liangliang Bai, Guannan Tang, Xiaolin Wang, Guangwen Cao, Meijin Huang, Jun Xiang, Huichuan Yu
Summary: This study found that the NTRK3 gene promoter was more frequently methylated in CRC, leading to suppressed gene expression. It was confirmed that NTRK3 promoter methylation was associated with survival outcome in CRC and a nomogram predicting survival outcome was developed. Moreover, NTRK3 promoter methylation also predicted survival outcomes in other tumors.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Plant Sciences
Ze-Ting Song, Lin-Lin Zhang, Jia-Jia Han, Ming Zhou, Jian-Xiang Liu
Summary: This study investigated the role of histone H3K4 methyltransferases SDG25 and ATX1 in heat stress tolerance in Arabidopsis, demonstrating their importance in regulating stress-responsive gene expression during both heat stress and stress recovery stages. Mutations of SDG25 and ATX1 were found to decrease histone H3K4me3 levels, increase DNA cytosine methylation, and inhibit the expression of a subset of heat stress-responsive genes during stress recovery. ChIP-qPCR results confirmed the binding of ATX1 to chromatin associated with these target genes, highlighting the impact of histone H3K4me3 on DNA methylation and transcriptional memory in plants under heat stress.
Article
Oncology
Ruth Pidsley, Dilys Lam, Wenjia Qu, Timothy J. Peters, Phuc-Loi Luu, Darren Korbie, Clare Stirzaker, Roger J. Daly, Phillip Stricker, James G. Kench, Lisa G. Horvath, Susan J. Clark
Summary: This study used methylome sequencing to investigate the DNA methylation patterns in prostate cancer patients, and identified methylation patterns associated with prostate cancer-specific mortality, as well as prognostic biomarkers. The combination of DNA methylation biomarkers and clinicopathological measures improved the prognostic models for prostate cancer mortality.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Chang Shi, Lizhi Zhang, Dan Chen, Hong Wei, Wenjing Qi, Pengxin Zhang, Huiqi Guo, Lei Sun
Summary: This study revealed the prognostic value and functional role of TMEM59L in various cancers, as well as the associated pathways and factors. TMEM59L may serve as a prognostic cancer biomarker and therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Debo Chen, Zhishan Chen, Zhitang Wang, Chengye Hong, Qinglan Wang, Peidong Yang, Zhidong Huang, Weibin Lian, Yiqin Huang, Wei Fu, Junjing Li, Zhipeng Hong
Summary: This research identified a lncRNA called SEMA3B-AS1 that is downregulated in triple negative breast cancer (TNBC) and is associated with unfavorable prognosis. Functional experiments showed that SEMA3B-AS1 inhibits tumor-initiating cell behaviors and suppresses tumor formation, migration, and invasion. Mechanistic insights revealed that SEMA3B-AS1 interacts with MLL4 to activate the expression of SEMA3B, a known tumor suppressor gene. This study enhances our understanding of the role of lncRNAs in TNBC and suggests their potential as therapeutic targets.
MOLECULAR CARCINOGENESIS
(2023)
Article
Cell Biology
Xin-yu Li, Wei-Ning Ma, Li-xin Su, Yuchen Shen, Liming Zhang, Yuhao Shao, Deming Wang, Zhenfeng Wang, Ming-Zhe Wen, Xi-tao Yang
Summary: The study comprehensively evaluated the expression of angiogenesis genes across 33 human cancer types, and found that a high angiogenesis score was associated with aggressive cancer types and poor patient survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Zhenchong Xiong, Lin Yang, Juan Ao, Jiarong Yi, Xiazi Zouxu, Wenjing Zhong, Jikun Feng, Weiling Huang, Xi Wang, Zeyu Shuang
Summary: This study developed a prognostic model based on BC-related DNA methylation pattern. The BCIP score, correlated with poor outcomes in BC, was established to portray the variation in DNA methylation pattern related to BC incidence. Genes associated with the BCIP score were found to be involved in cancer immunity. The BCIP score was negatively correlated with T cell infiltration and immune checkpoint inhibitor response markers in BC tissues.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Masashi Nishimura, Yoshifumi Kimizuka, Takunori Ogawa, Motohiro Tsuchiya, Yoshiki Kato, Akira Matsukida, Shunya Igarashi, Koki Ito, Yusuke Serizawa, Tomomi Tanigaki, Yuji Fujikura, Yuka Katsurada, Sho Ogata, Akihiko Kawana
Summary: This study reports a case of IgG4-related retroperitoneal fibrosis occurring after chemotherapy. The patient showed improvement after discontinuing immunotherapy and receiving steroid treatment.
Article
Oncology
Yuta Ohishi, Yoko Nakanishi, Yukari Hirotani, Atsuko Suzuki, Tomoyuki Tanino, Haruna Nishimaki-Watanabe, Hiroko Kobayashi, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Kentaro Hayashi, Yoshiko Nakagawa, Tetsuo Shimizu, Ichiro Tsujino, Noriaki Takahashi, Yasuhiro Gon, Shinobu Masuda
Summary: This study aimed to investigate the clinicopathological differences and therapeutic response of NSCLC patients with SDC4::ROS1 fusion to crizotinib. The study found that different ROS1 fusion partners may affect the efficacy of crizotinib and patient prognosis. In addition, higher expression levels of ROS1 and pERK1/2 in tumor cells of case 2 may be related to the therapeutic response and prognosis.
Review
Oncology
Zitong Zheng, Juanjuan Liu, Junling Ma, Runting Kang, Zhen Liu, Jiangyong Yu
Summary: Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited treatment options. Over the past decade, immunotherapy has made progress in the treatment of SCLC, but current immune checkpoint inhibitors have limited benefits for patient survival. Therefore, it is important to explore new targets and develop drugs with novel mechanisms for immunotherapy in SCLC.
Article
Oncology
Kazuto Sugai, Kojiro Nakaoka, Rika Tobita, Shinji Kikuchi, Kei Inoue, Midori Enokido, Moriyuki Kiyoshima
Summary: This article presents a case of multilocular mediastinal cyst leading to the development of thymic cancer. Resection of multilocular anterior mediastinal cysts should be considered due to the challenges in preoperative diagnosis, the potential for coexisting tumors with cysts, and the risk of malignant tumor development.
