Review
Medicine, General & Internal
Rajeel Imran, Ghada A. Mohamed, Fadi Nahab
Summary: The field of acute stroke treatment has seen significant progress, particularly in understanding the pathophysiology of acute ischemic injury and neuroimaging thrombolysis therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Sine Mette Ogendahl Buus, Marie Louise Schmitz, Pia Cordsen, Soren Paaske Johnsen, Grethe Andersen, Claus Ziegler Simonsen
Summary: Despite having tax-funded universal healthcare, there are socioeconomic inequalities in reperfusion treatment rates among ischemic stroke patients.
Review
Medicine, General & Internal
Scott J. Mendelson, Shyam Prabhakaran
Summary: Stroke is a major cause of death and disability in the US, with TIA and AIS requiring different treatment approaches. Dual antiplatelet therapy can reduce stroke risk for high-risk TIA patients, while thrombolysis and mechanical thrombectomy improve outcomes for disabling AIS patients.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Kanta Tanaka, Hiroshi Yamagami, Takeshi Yoshimoto, Kazutaka Uchida, Takeshi Morimoto, Kazunori Toyoda, Nobuyuki Sakai, Shinichi Yoshimura
Summary: This study compared outcomes in acute stroke patients with large-vessel occlusion and prestroke disability who underwent endovascular therapy (EVT) versus medical management. Results showed that patients who received EVT had better functional outcomes and higher proportion of favorable outcomes compared to those in the medical management group.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesco Pacchiano, Mario Tortora, Sabrina Criscuolo, Katya Jaber, Pasquale Acierno, Marta De Simone, Fabio Tortora, Francesco Briganti, Ferdinando Caranci
Summary: This review summarizes the recent developments and future forecasts of artificial intelligence in acute ischemic stroke. The use of artificial intelligence systems, particularly machine learning and deep learning using convoluted neural networks, has gained attention in categorizing, predicting, and guiding the right therapeutic procedures for stroke patients. Various studies and software applications have been developed to assist neuroradiologists and stroke teams in improving patient outcomes.
Review
Nursing
Heather H. Washington, Kimberly R. Glaser, Nneka Lotea Ifejika
Summary: This article discusses the pathophysiology, risk factors, presentation, as well as evidence-based treatments, nursing assessments, and monitoring protocols that are critical to patient recovery for different types of ischemic stroke. Improving outcomes for patients experiencing ischemic stroke requires faster recognition and appropriate intervention within the treatment window.
AMERICAN JOURNAL OF NURSING
(2021)
Article
Clinical Neurology
Hong-Kyun Park, Sang-Bae Ko, Keun-Hwa Jung, Min Uk Jang, Dae-Hyun Kim, Joon-Tae Kim, Jay Chol Choi, Hye Seon Jeong, Chulho Kim, Ji Hoe Heo, Joung-Ho Rha, Sun U. Kwon, Jong S. Kim, Byung-Chul Lee, Hee-Joon Bae, Byung-Woo Yoon, Keun-Sik Hong
Summary: Antithrombotic therapy plays a crucial role in the management and prevention of acute ischemic stroke (AIS). Since the first edition of the Korean Clinical Practice Guideline (CPG) was released in 2009, significant progress has been made in this field, leading to an updated guideline aimed at improving acute stroke care. However, treatment decisions should take into account the individual medical conditions of patients.
Review
Immunology
Yan-mei Qiu, Chun-lin Zhang, An-qi Chen, Hai-ling Wang, Yi-fan Zhou, Ya-nan Li, Bo Hu
Summary: Blood-Brain Barrier (BBB) disruption is a crucial pathophysiological process in acute ischemic stroke, where the rapid activation of immune cells plays a critical role. Infiltrating immune cells increase BBB permeability, causing microvascular disorder, but also promote BBB repair and angiogenesis. Understanding the inflammatory mechanisms behind BBB disruption can lead to the development of more effective therapeutics for acute ischemic stroke.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Clinical Neurology
Zachary B. Bulwa, Scott J. Mendelson, James R. Brorson
Summary: Recent studies have shown that acute interventions following minor ischemic stroke or TIA can reduce early stroke recurrence rates, indicating a transition from a vulnerable state to a more stable state in acute stroke patients. Early treatment with antiplatelets, oral anticoagulants for cardioembolic stroke, and statins for atherosclerotic stroke can help prevent early recurrence and promote stabilization of vulnerable arterial plaque.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Vanessa H. E. Chen, Grace K. H. Lee, Choon-Han Tan, Aloysius S. T. Leow, Ying-Kiat Tan, Claire Goh, Anil Gopinathan, Cunli Yang, Bernard P. L. Chan, Vijay K. Sharma, Benjamin Y. Q. Tan, Leonard L. L. Yeo
Summary: This study evaluated the efficacy and safety of concomitant or rescue intra-arterial adjunctive medications in patients with acute ischemic stroke and large vessel occlusion undergoing mechanical thrombectomy. Results showed that patients treated with combination therapy had a higher likelihood of achieving good functional outcome and lower 90-day mortality, with no significant difference in successful recanalization and symptomatic intracranial hemorrhage compared to patients treated with MT alone.
Article
Health Care Sciences & Services
Angel Estella, Miriam Perez Ruiz, Juan Jose Serrano
Summary: This study aimed to compare the combined effect and safety of tenecteplase and alteplase in ischemic stroke patients. The results showed no significant differences in successful recanalization and functional outcome between the two drugs, but tenecteplase had worse neurological results after 24 hours.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Shuanghu Wang, Kun Liu, Quan Zhou, Cong Xu, Junbin Gao, Zhen Wang, Fei Wang, Bin Chen, Yicheng Ye, Juanfeng Ou, Jiamiao Jiang, Daniela A. Wilson, Shuwen Liu, Fei Peng, Yingfeng Tu
Summary: Biodegradable microswimmers, particularly the hydrogen-powered ones, show promising potential for precise and active therapy of acute ischemic stroke by scavenging reactive oxygen species and inflammation through locally generated hydrogen gas. This innovative approach demonstrates efficient efficacy on anti-ischemic stroke with minimal adverse effects, offering great promise for future clinical application in treating oxidative stress induced diseases.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
Wenxiu He, Zhiwen Zhang, Xianyi Sha
Summary: This review outlines the emerging approaches of nanoparticles in the effective treatment of ischemic stroke, including recanalization therapy, neuroprotection therapy, and combination therapy. It reveals the potentials and challenges of nanoparticles in treating ischemic stroke, and proposes new thoughts and perspectives for the design of feasible nanoparticles for effective treatment.
Review
Pharmacology & Pharmacy
T. Marc Eastin, Justin A. Dye, Promod Pillai, Miguel A. Lopez-Gonzalez, Lei Huang, John H. Zhang, Warren W. Boling
Summary: Stroke is a significant cause of death and disability worldwide, with post-stroke cognitive impairment causing a decline in the quality of life. Currently, only pharmacological and mechanical thrombolysis interventions are advised for revascularization. However, these treatments are limited to the acute phase of stroke. Advances in neuroimaging and interventional devices have expanded the potential revascularization window, with delayed revascularization showing positive outcomes beyond the recommended therapeutic window. This review discusses the understanding of ischemic stroke, the latest revascularization doctrine, and evidence from clinical studies on effective delayed revascularization.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ivan B. Filippenkov, Andrey V. Khrunin, Ivan V. Mozgovoy, Lyudmila V. Dergunova, Svetlana A. Limborska
Summary: Complex diseases affecting the central nervous system, such as ischemic stroke and Alzheimer's disease, pose significant challenges to society. Recent studies have revealed shared genetic and molecular characteristics between these two diseases. This review summarizes the genomics and RNA biology studies of ischemic stroke and Alzheimer's disease, highlighting their interconnected nature and discussing potential genomic markers and RNA molecules for predicting disease risks and developing therapies.
Review
Critical Care Medicine
Jing Chen, Dalong Sun, Weiming Yang, Mingli Liu, Shufan Zhang, Jinhua Peng, Chuancheng Ren
JOURNAL OF INTENSIVE CARE MEDICINE
(2018)
Article
Gastroenterology & Hepatology
Tingting Hu, Dalong Sun, Jie Zhang, Ruyi Xue, Harry L. A. Janssen, Wenqing Tang, Ling Dong
HEPATOLOGY RESEARCH
(2018)
Article
Medicine, General & Internal
Jing Chen, Mingli Liu, Dalong Sun, Yan Jin, Tianrao Wang, Chuancheng Ren
Article
Multidisciplinary Sciences
Dalong Sun, Jing Chen, Longzi Liu, Guangxi Zhao, Pingping Dong, Bingrui Wu, Jun Wang, Ling Dong
Article
Emergency Medicine
Dalong Sun, Fengyuan Chen, Chenxi Wang
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2014)
Article
Neurosciences
Jing Chen, Dalong Sun, Yonghui Shi, Wei Jin, Yanbin Wang, Qian Xi, Chuancheng Ren
NEUROSCIENCE LETTERS
(2018)
Article
Gastroenterology & Hepatology
Wenqing Tang, Yi Zhou, Dalong Sun, Ling Dong, Jinglin Xia, Biwei Yang
HEPATOLOGY RESEARCH
(2019)
Article
Neurosciences
Jing Chen, Dalong Sun, Yonghui Shi, Wei Jin, Yanbin Wang, Qian Xi, Chuancheng Ren
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Dalong Sun, Tiancheng Luo, Pingping Dong, Ningping Zhang, Jing Chen, Shuncai Zhang, Ling Dong, Harry L. A. Janssen, Si Zhang
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Article
Oncology
Bingrui Wu, Dalong Sun, Lijie Ma, Yiran Deng, Si Zhang, Ling Dong, She Chen
Article
Neuroimaging
Jing Chen, Dalong Sun, Yonghui Shi, Wei Jin, Yanbin Wang, Qian Xi, Chuancheng Ren
Summary: In this study, static and dynamic voxel-mirrored homotopic connectivity (VMHC) were analyzed in stroke patients and healthy controls, revealing significant alterations in VMHC in different brain regions of stroke patients. A negative correlation was found between dynamic VMHC and FMA scores.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Dalong Sun, Tiancheng Luo, Pingping Dong, Ningping Zhang, Jing Chen, Shuncai Zhang, Longzi Liu, Ling Dong, Si Zhang
Article
Clinical Neurology
Jing Chen, Dalong Sun, Shufan Zhang, Yonghui Shi, Fenglei Qiao, Yafei Zhou, Jun Liu, Chuancheng Ren