The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function

Enhancing Cardiac Triacylglycerol Metabolism Improves Recovery From Ischemic Stress

(2015) Stephen C. Kolwicz et al.   DIABETES

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors

(2015) Jason E. Imbriglio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

(2015) Kentaro Futatsugi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors with a 1H-Pyrrolo[2,3-b]pyridine Core

(2014) Mun Ock Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Dietary Fat Supply to Failing Hearts Determines Dynamic Lipid Signaling for Nuclear Receptor Activation and Oxidation of Stored Triglyceride

(2014) Ryan Lahey et al.   CIRCULATION

Cardiomyocyte-specific Loss of Diacylglycerol Acyltransferase 1 (DGAT1) Reproduces the Abnormalities in Lipids Found in Severe Heart Failure

(2014) Li Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation

(2013) Petra C. Kienesberger et al.   CARDIOVASCULAR RESEARCH

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Myocardial Adipose Triglyceride Lipase Overexpression Protects Diabetic Mice From the Development of Lipotoxic Cardiomyopathy

(2013) T. Pulinilkunnil et al.   DIABETES

Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure

(2012) Aalap Chokshi et al.   CIRCULATION

Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy

(2012) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing

(2012) Samnang Tep et al.   JOURNAL OF LIPID RESEARCH

Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying

(2012) Gene P. Ables et al.   JOURNAL OF LIPID RESEARCH

Multiphasic triacylglycerol dynamics in the intact heart during acute in vivo overexpression of CD36

(2012) Andrew N. Carley et al.   JOURNAL OF LIPID RESEARCH

Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice

(2012) Li Liu et al.   JOURNAL OF LIPID RESEARCH

DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes

(2011) Charles A. Harris et al.   JOURNAL OF LIPID RESEARCH

DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle

(2011) Li Liu et al.   JOURNAL OF LIPID RESEARCH

Myocardial ATGL Overexpression Decreases the Reliance on Fatty Acid Oxidation and Protects against Pressure Overload-Induced Cardiac Dysfunction

(2011) P. C. Kienesberger et al.   MOLECULAR AND CELLULAR BIOLOGY

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Rescue of Cardiomyopathy in Peroxisome Proliferator-Activated Receptor-α Transgenic Mice by Deletion of Lipoprotein Lipase Identifies Sources of Cardiac Lipids and Peroxisome Proliferator-Activated Receptor-α Activators

(2010) Jennifer G. Duncan et al.   CIRCULATION

Preferential Oxidation of Triacylglyceride-Derived Fatty Acids in Heart Is Augmented by the Nuclear Receptor PPARα

(2010) Natasha H. Banke et al.   CIRCULATION RESEARCH

Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity inDgat1−/−mice

(2010) Bonggi Lee et al.   JOURNAL OF LIPID RESEARCH

Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding

(2009) Jordan J. Wright et al.   CARDIOVASCULAR RESEARCH

Increased Glucose Uptake and Oxidation in Mouse Hearts Prevent High Fatty Acid Oxidation but Cause Cardiac Dysfunction in Diet-Induced Obesity

(2009) Jie Yan et al.   CIRCULATION

DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity

(2009) Li Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function

(2008) R. W. van der Meer et al.   EUROPEAN HEART JOURNAL

Thematic Review Series: Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis

(2008) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH