TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia
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Title
TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia
Authors
Keywords
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Journal
Scientific Reports
Volume 8, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-03-09
DOI
10.1038/s41598-018-22858-w
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Note: Only part of the references are listed.- Mutant Huntingtin Disrupts the Nuclear Pore Complex
- (2017) Jonathan C. Grima et al. NEURON
- Toxic PRnpoly-dipeptides encoded by theC9orf72repeat expansion block nuclear import and export
- (2017) Kevin Y. Shi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus
- (2016) Naoki Tajiri et al. CNS Neuroscience & Therapeutics
- Optogenetic control of nuclear protein export
- (2016) Dominik Niopek et al. Nature Communications
- Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
- (2016) Steven Boeynaems et al. Scientific Reports
- Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
- (2015) Jerome Mertens et al. Cell Stem Cell
- The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
- (2015) Ke Zhang et al. NATURE
- GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
- (2015) Brian D. Freibaum et al. NATURE
- Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination
- (2015) Jeffery D Haines et al. NATURE NEUROSCIENCE
- Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
- (2015) Axel Freischmidt et al. NATURE NEUROSCIENCE
- Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
- (2015) Ana Jovičić et al. NATURE NEUROSCIENCE
- Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1
- (2015) Sami J. Barmada et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA
- (2015) A. C. Woerner et al. SCIENCE
- Epidemiology of amyotrophic lateral sclerosis in Minnesota: A year-long population based study
- (2015) Caitlin J. Harper et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning
- (2015) Koray Kırlı et al. eLife
- AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats
- (2015) Kasey L Jackson et al. Molecular Therapy-Methods & Clinical Development
- Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation
- (2014) S. M. Hattangadi et al. BLOOD
- Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis
- (2014) K L Jackson et al. GENE THERAPY
- Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
- (2014) Sami J Barmada et al. Nature Chemical Biology
- Preclinical Evaluation of the Novel, Orally Bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in Spontaneous Canine Cancer: Results of a Phase I Study
- (2014) Cheryl A. London et al. PLoS One
- RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy
- (2013) Ryoko Ihara et al. HUMAN MOLECULAR GENETICS
- Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276
- (2013) J Schmidt et al. LEUKEMIA
- Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 kDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis
- (2013) Robert D Dayton et al. MOLECULAR THERAPY
- Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
- (2013) Hyung-Jun Kim et al. NATURE GENETICS
- Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1
- (2013) Qingxiang Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43
- (2012) Azusa Uchida et al. BRAIN
- Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry
- (2012) Ketan Thakar et al. MOLECULAR & CELLULAR PROTEOMICS
- Advances in understanding the molecular basis of frontotemporal dementia
- (2012) Rosa Rademakers et al. Nature Reviews Neurology
- Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis
- (2011) David B. Wang et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
- (2011) Lionel M. Igaz et al. JOURNAL OF CLINICAL INVESTIGATION
- Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology
- (2011) M. H. B. Huisman et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
- (2011) Han-Xiang Deng et al. NATURE
- Identifying polyglutamine protein species in situ that best predict neurodegeneration
- (2011) Jason Miller et al. Nature Chemical Biology
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
- (2011) Mariely DeJesus-Hernandez et al. NEURON
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- (2011) Alan E. Renton et al. NEURON
- High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice
- (2011) Jin Hee Kim et al. PLoS One
- Pathogenic TARDBP Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Disease-Associated Pathways
- (2011) Sami J. Barmada et al. REVIEWS IN THE NEUROSCIENCES
- Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration
- (2010) Agnes L. Nishimura et al. BRAIN
- ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
- (2010) Dorothee Dormann et al. EMBO JOURNAL
- Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
- (2010) S. J. Barmada et al. JOURNAL OF NEUROSCIENCE
- Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 Proteinopathy
- (2010) N. F. Liachko et al. JOURNAL OF NEUROSCIENCE
- Expansive Gene Transfer in the Rat CNS Rapidly Produces Amyotrophic Lateral Sclerosis Relevant Sequelae When TDP-43 is Overexpressed
- (2010) David B Wang et al. MOLECULAR THERAPY
- Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
- (2010) Andrew C. Elden et al. NATURE
- Mutations of optineurin in amyotrophic lateral sclerosis
- (2010) Hirofumi Maruyama et al. NATURE
- Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
- (2010) Janel O. Johnson et al. NEURON
- A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
- (2010) A. S. Tsvetkov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
- (2010) Hans Wils et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epidemiology of ALS in Padova district, Italy, from 1992 to 2005
- (2009) V. Cima et al. EUROPEAN JOURNAL OF NEUROLOGY
- Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
- (2009) Edor Kabashi et al. HUMAN MOLECULAR GENETICS
- Molecular Neuropathology of TDP-43 Proteinopathies
- (2009) Manuela Neumann INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Faithful Expression of Multiple Proteins via 2A-Peptide Self-Processing: A Versatile and Reliable Method for Manipulating Brain Circuits
- (2009) W. Tang et al. JOURNAL OF NEUROSCIENCE
- Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery
- (2009) Brian D. Freibaum et al. JOURNAL OF PROTEOME RESEARCH
- Mimicking Aspects of Frontotemporal Lobar Degeneration and Lou Gehrig's Disease in Rats via TDP-43 Overexpression
- (2009) Jason B Tatom et al. MOLECULAR THERAPY
- Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
- (2009) C. Vance et al. SCIENCE
- Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
- (2009) T. J. Kwiatkowski et al. SCIENCE
- The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia
- (2008) Ian RA Mackenzie et al. CURRENT OPINION IN NEUROLOGY
- Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation
- (2008) Matthew J. Winton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural determinants of the cellular localization and shuttling of TDP-43
- (2008) Y. M. Ayala et al. JOURNAL OF CELL SCIENCE
- The analysis of survival data in nephrology: basic concepts and methods of Cox regression
- (2008) Paul C. van Dijk et al. KIDNEY INTERNATIONAL
- A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity
- (2008) B. S. Johnson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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