Article
Pharmacology & Pharmacy
Jingxuan Lu, Jingwen Luo, Jie Li, Shiyan Fu, Yonghong Ran, Juan Li, Yazhen Zhao, Yuhui Hao
Summary: A nanoscale complex of cerium(III) was developed to prevent radiation-induced pulmonary fibrosis (RIPF). The complex demonstrated the ability to alleviate RIPF by inhibiting epithelial-mesenchymal transition (EMT) and also showed antitumor effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Cell Biology
Malgorzata Wygrecka, Ioannis Alexopoulos, Daniel P. Potaczek, Liliana Schaefer
Summary: ApoA-I plays an important role in reverse cholesterol transport and also possesses anti-inflammatory and antioxidative functions. Dysfunctional apoA-I or its low abundance can lead to the formation of foam cells in alveolar macrophages. Increased numbers of foam cells have been observed in the lungs of mice exposed to certain substances and in patients with lung fibrosis. Understanding the role of apoA-I in lung fibrosis provides potential avenues for therapeutic development.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xu-Yang Chen, Yan-Chao Dong, Yuan-Yuan Yu, Man Jiang, Wen-Jie Bu, Ping Li, Zhi-Jie Sun, De-Li Dong
Summary: This study found that nitazoxanide activated AMPK and inhibited STAT3 signaling, and effectively improved pulmonary fibrosis in mice. It suggests that nitazoxanide has potential application in the treatment of pulmonary fibrosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dongke Yu, Yu Xiang, Tingting Gou, Rongsheng Tong, Chuan Xu, Lu Chen, Ling Zhong, Jianyou Shi
Summary: Pulmonary fibrosis is an end-stage change in a group of lung diseases characterized by fibroblast proliferation and accumulation of extracellular matrix, accompanied by inflammatory damage and tissue structure destruction. It has a serious impact on respiratory function and appears as progressive dyspnea. The incidence of pulmonary fibrosis-related diseases is increasing, but effective drugs are lacking and research has not made significant breakthroughs.
BIOORGANIC CHEMISTRY
(2023)
Article
Anatomy & Morphology
Dalei Li, Mengying Wang, Rong Fan, Zeyu Song, Zhenyuan Li, Hailin Gan, Huaying Fan
Summary: This study investigated the interaction between Clusterin and TRPM2 in acute myocardial infarction (AMI). The results showed that Clusterin expression decreased while TRPM2 expression increased in AMI. Knockout of TRPM2 protected against myocardial injury and upregulated Clusterin expression. Moreover, treatment with Clusterin or silencing of TRPM2 improved cell viability and decreased TRPM2 expression in hypoxic conditions.
Article
Multidisciplinary Sciences
Chen Ni, Xiaohan Lou, Xiaohan Yao, Linlin Wang, Jiajia Wan, Xixi Duan, Jialu Liang, Kaili Zhang, Yuanyuan Yang, Li Zhang, Chanjun Sun, Zhenzhen Li, Ming Wang, Linyu Zhu, Dekang Lv, Zhihai Qin
Summary: This study reveals a mechanism by which a subset of zinc-transporter positive cancer-associated fibroblasts directly interacts with lung cancer cells through gap junctions, promoting chemoresistance in tumors. This finding provides insights into the role of fibroblast-tumor cell interactions in lung cancer chemo-resistance.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Yue Chen, Xin Yi, Bo Huo, Yi He, Xian Guo, Zihao Zhang, Xiaoxuan Zhong, Xin Feng, Ze-Min Fang, Xue-Hai Zhu, Xiang Wei, Ding-Sheng Jiang
Summary: Smooth muscle cell loss and aortic dissection (AD) development are associated with ferroptosis, a novel iron-dependent regulated cell death driven by lipid peroxidation accumulation. This study found that the ferroptosis-related molecules and lipid peroxidation product were increased in the aorta of AD. The histone methyltransferase inhibitor BRD4770 showed a protective effect on ferroptosis of smooth muscle cells (SMCs) and attenuated aortic dilation and mortality in a mouse AD model.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sha Wang, Wei Luo, Jie Huang, Mengling Chen, Jiawei Ding, Yusi Cheng, Wei Zhang, Shencun Fang, Jing Wang, Jie Chao
Summary: This study found that m(6)A-modified circRNA plays an important role in pulmonary fibrosis, participating in silica-induced fibroblast dysfunction by targeting specific proteins. The study also revealed the regulatory mechanism of METTL3 in this process.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Respiratory System
Ting Shu, Jiawei Zhang, Yitian Zhou, Zhihua Chen, Jinqiu Li, Qihao Tang, Wenqi Lei, Yanjiang Xing, Jing Wang, Chen Wang
Summary: In patients with pulmonary arterial hypertension (PAH) and PH mice, there is increased infiltration of eosinophils (EOS) in lung tissues but a lower percentage in peripheral blood. Deficiency of EOS exacerbates PH and leads to increased infiltration of neutrophils and monocytes/macrophages. EOS play a protective role in PH development by producing 14/17-HDHA that suppresses perivascular inflammation and inhibits pulmonary artery smooth muscle cell proliferation.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Medicine, General & Internal
Qiang Zhang, Yuanyi Yue, Rui Zheng
Summary: In this study, differentially expressed proteins (DEPs) were identified between COPD patients and normal smokers using iTRAQ-based proteomic analysis. Clusterin (CLU) was identified as a potential serum biomarker candidate. CLU levels were significantly increased in COPD patients and correlated with lung function and imaging parameters. Additionally, cigarette smoke extract (CSE) treatment promoted lung fibroblast activation and fibrosis, which was partially reversed by CLU silencing.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Xiaofan Lai, Shaojie Huang, Yingying Lin, Yuan Qiu, Lvya Pu, Sijia Lin, Qihao Zeng, Wenqi Huang, Zhongxing Wang
Summary: By conducting experiments on various models of experimental pulmonary fibrosis, adeno-associated virus mediated DACT2 overexpression was found to significantly alleviate pulmonary fibrosis. DACT2 inhibits TGF-beta-induced myofibroblast differentiation by promoting lysosome-mediated LDHA degradation and thus suppressing glycolysis in myofibroblasts. Therefore, DACT2 may serve as a novel pharmacological target for the treatment of pulmonary fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Jacek Rogala, Joanna Dreszer, Urszula Malinowska, Marek Waligora, Agnieszka Pluta, Ingrida Antonova, Andrzej Wrobel
Summary: The study compared individuals who continued their engagement during lockdown with control data collected before the pandemic, finding that individuals during the pandemic exhibited higher extraversion and stronger connectivity, as well as better cognitive performance under long-term stress. Additionally, individuals during the pandemic showed increased EEG connectivity during lockdown.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Rizwana Begum Syed Nabi, Raheem Shahzad, Rupesh Tayade, Muhammad Shahid, Adil Hussain, Muhammad Waqas Ali, Byung-Wook Yun
Summary: This study evaluated the ability of a plant growth-promoting rhizobacterium to control tomato wilt disease caused by Fusarium oxysporum and promote plant growth. The results showed significant inhibition of fungal growth, protection of susceptible tomato cultivars, and promotion of plant growth and biomass production in both susceptible and tolerant cultivars. Further analysis revealed higher amino acid production and alterations in plant defense hormone levels, suggesting that the rhizobacterium reduces the effects of Fusarium wilt disease by modulating endogenous phytohormones and amino acid levels.
Article
Pharmacology & Pharmacy
Xiaohe Li, Rui Liu, Yunyao Cui, Jingjing Liang, Zhun Bi, Shimeng Li, Yang Miao, Liang Zhang, Xiaoping Li, Honggang Zhou, Cheng Yang
Summary: The antiviral drug remdesivir can preventatively alleviate the severity of pulmonary fibrosis and improve pulmonary function. In vitro experiments showed that remdesivir suppresses lung fibroblast and alveolar epithelial cell activation, improving the pathological process.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Emmanuelle Born, Larissa Lipskaia, Marielle Breau, Amal Houssaini, Delphine Beaulieu, Elisabeth Marcos, Remi Pierre, Marcio Do Cruzeiro, Marine Lefevre, Genevieve Derumeaux, Dmitry V. Bulavin, Marion Delcroix, Rozenn Quarck, Virinder Reen, Jesus Gil, David Bernard, Jean-Michel Flaman, Serge Adnot, Shariq Abid
Summary: This study investigated the role of senescent cells in patients with pulmonary arterial hypertension and animal models. The findings revealed that clearance of senescent cells resulted in vascular remodeling and damage to the pulmonary artery.
Article
Oncology
Lena Schreiberhuber, Chiara Herzog, Charlotte D. Vavourakis, Elisa Redl, Christine Kastner, Allison Jones, Iona Evans, Michal Zikan, David Cibula, Peter Widschwendter, Karin Pfau, Barbara Math, Martin Seewald, Sylvain Amory, Peter Obrist, Martin Widschwendter
Summary: The majority of women with endometrial and cervical cancers experience abnormal vaginal bleeding, but only a small proportion of women with vaginal bleeding actually have these types of cancer. A new test called WID-qEC has been developed to accurately identify women with abnormal bleeding who may have endometrial or cervical cancer. This test shows high accuracy in detecting cervical cancer and performs better than cytology.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Rheumatology
David Roofeh, Kevin K. Brown, Ella A. Kazerooni, Donald Tashkin, Shervin Assassi, Fernando Martinez, Athol U. Wells, Ganesh Raghu, Christopher P. Denton, Lorinda Chung, Anna-Maria Hoffmann-Vold, Oliver Distler, Kerri A. Johannson, Yannick Allanore, Eric L. Matteson, Leticia Kawano-Dourado, John D. Pauling, James R. Seibold, Elizabeth R. Volkmann, Simon L. F. Walsh, Chester Oddis, Eric S. White, Shaney L. Barratt, Elana J. Bernstein, Robyn T. Domsic, Paul F. Dellaripa, Richard Conway, Ivan Rosas, Nitin Bhatt, Vivien Hsu, Francesca Ingegnoli, Bashar Kahaleh, Puneet Garcha, Nishant Gupta, Surabhi Khanna, Peter Korsten, Celia Lin, Stephen C. Mathai, Vibeke Strand, Tracy J. Doyle, Virginia Steen, Donald F. Zoz, Juan Ovalles-Bonilla, Ignasi Rodriguez-Pinto, Padmanabha D. Shenoy, Andrew Lewandoski, Elizabeth Belloli, Alain Lescoat, Vivek Nagaraja, Wen Ye, Suiyuan Huang, Toby Maher, Dinesh Khanna
Summary: This study aimed to establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD). The results showed that using the proposed conceptual framework, international experts were able to achieve a consensus on classifying SSc-ILD patients along the dimensions of disease severity, risk of progression and progression over time.
Article
Rheumatology
Christopher P. Denton, Nicole S. Goh, Stephen M. Humphries, Toby M. Maher, Robert Spiera, Anand Devaraj, Lawrence Ho, Christian Stock, Elvira Erhardt, Margarida Alves, Athol U. Wells
Summary: Data from the SENSCIS trial suggests that patients with SSc-ILD are at risk of ILD progression and can benefit from nintedanib regardless of the extent of fibrotic ILD at baseline.
Article
Critical Care Medicine
Joshua J. Solomon, Sonye K. Danoff, Felix A. Woodhead, Shelley Hurwitz, Rie Maurer, Ian Glaspole, Paul F. Dellaripa, Bibek Gooptu, Robert Vassallo, P. Gerard Cox, Kevin R. Flaherty, Huzaifa Adamali, Michael A. Gibbons, Lauren Troy, Ian A. Forrest, Joseph A. Lasky, Lisa G. Spencer, Jeffrey Golden, Mary Beth Scholand, Nazia Chaudhuri, Mark A. Perrella, David A. Lynch, Daniel C. Chambers, Martin Kolb, Cathie Spino, Ganesh Raghu, Hilary J. Goldberg, Ivan Rosas
Summary: This study evaluated the safety, tolerability, and efficacy of pirfenidone for the treatment of patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The results showed that although it did not meet the primary endpoint, pirfenidone slowed the rate of decline in lung function in patients with RA-ILD.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Critical Care Medicine
Marlies S. Wijsenbeek, Catharina C. Moor, Kerri A. Johannson, Peter Jackson, Yet H. Khor, Yasuhiro Kondoh, Sujeet K. Rajan, Gabriela C. Tabaj, Brenda E. Varela, Pieter van der Wal, Richard N. van Zyl-Smit, Michael Kreuter, Toby M. Maher
Summary: The use of smartphones and the internet has facilitated self-monitoring and hybrid-care models, with the COVID-19 pandemic further fueling remote monitoring in interstitial lung diseases (ILDs). Home monitoring in ILD has the potential to enhance access to specialized care, alleviate healthcare system burdens, improve patient quality of life, identify disease deterioration, inform treatment decisions, and simplify clinical trials. However, there are challenges in terms of technical, analytical, and implementation issues. In this Series paper, experiences, challenges, and future perspectives of home monitoring in ILD are discussed.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Critical Care Medicine
Anna L. Peljto, Rachel Z. Blumhagen, Avram D. Walts, Jonathan Cardwell, Julia Powers, Tamera J. Corte, Joanne L. Dickinson, Ian Glaspole, Yuben P. Moodley, Martina Koziar Vasakova, Elisabeth Bendstrup, Jesper R. Davidsen, Raphael Borie, Bruno Crestani, Philippe Dieude, Francesco Bonella, Ulrich Costabel, Gunnar Gudmundsson, Seamas C. Donnelly, Jim Egan, Michael T. Henry, Michael P. Keane, Marcus P. Kennedy, Cormac McCarthy, Aoife N. McElroy, Joshua A. Olaniyi, Katherine M. A. O'Reilly, Luca Richeldi, Paolo M. Leone, Venerino Poletti, Francesco Puppo, Sara Tomassetti, Valentina Luzzi, Nurdan Kokturk, Nesrin Mogulkoc, Christine A. Fiddler, Nikhil Hirani, R. Gisli Jenkins, Toby M. Maher, Philip L. Molyneaux, Helen Parfrey, Rebecca Braybrooke, Timothy S. Blackwell, Peter D. Jackson, Steven D. Nathan, Mary K. Porteous, Kevin K. Brown, Jason D. Christie, Harold R. Collard, Oliver Eickelberg, Elena E. Foster, Kevin F. Gibson, Marilyn Glassberg, Daniel J. Kass, Jonathan A. Kropski, David Lederer, Angela L. Linderholm, Jim Loyd, Susan K. Mathai, Sydney B. Montesi, Imre Noth, Justin M. Oldham, Amy J. Palmisciano, Cristina A. Reichner, Mauricio Rojas, Jesse Roman, Neil Schluger, Barry S. Shea, Jeffrey J. Swigris, Paul J. Wolters, Yingze Zhang, Cecilia M. A. Prele, Juan I. Enghelmayer, Maria Otaola, Christopher J. Ryerson, Mauricio Salinas, Martina Sterclova, Tewodros H. Gebremariam, Marjukka Myllarniemi, Roberto G. Carbone, Haruhiko Furusawa, Masaki Hirose, Yoshikazu Inoue, Yasunari Miyazaki, Ken Ohta, Shin Ohta, Tsukasa Okamoto, Dong Soon Kim, Annie Pardo, Moises Selman, Alvaro U. Aranda, Moo Suk Park, Jong Sun Park, Jin Woo Song, Maria Molina-Molina, Lurdes Planas-Cerezales, Gunilla Westergren-Thorsson, Albert V. Smith, Ani W. Manichaikul, John S. Kim, Stephen S. Rich, Elizabeth C. Oelsner, R. Graham Barr, Jerome I. Rotter, Josee Dupuis, George O'Connor, Ramachandran S. Vasan, Michael H. Cho, Edwin K. Silverman, Marvin I. Schwarz, Mark P. Steele, Joyce S. Lee, Ivana V. Yang, Tasha E. Fingerlin, David A. Schwartz
Summary: This study investigated the role of rare variants, genome-wide, on the risk of idiopathic pulmonary fibrosis (IPF) using whole-genome sequencing. The results showed that rare variants within the TERT and RTEL1 genes were significantly associated with IPF, along with well-established common variants. Therefore, including TERT, RTEL1, common variants, and environmental risk factors in risk profiling and IPF therapy development is likely to have the largest impact on this complex disease.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Katherine J. Myall, Alex G. West, Jennifer L. Martinovic, Jodie L. Lam, Diana Roque, Zhe Wu, Toby M. Maher, Philip L. Molyneaux, Eui-Sik Suh, Brian D. Kent
Summary: Prolonged NH, but not OSA, is associated with worsening disease-related quality of life and increased mortality in patients with F-ILD.
Article
Respiratory System
Carl J. Reynolds, Fabiola Del Greco, Richard J. Allen, Carlos Flores, R. Gisli Jenkins, Toby M. Maher, Philip L. Molyneaux, Imre Noth, Justin M. Oldham, Louise Wain, Jiyuan An, Jue-Sheng Ong, Stuart MacGregor, Tom A. Yates, Paul Cullinan, Cosetta Minelli
Summary: Using bidirectional Mendelian randomisation (MR), it was found that gastro-oesophageal reflux disease (GORD) increases the risk of idiopathic pulmonary fibrosis (IPF), but there is no evidence that IPF increases the risk of GORD. This suggests that GORD should be considered in future studies of IPF risk and the mechanisms underlying the effect of GORD on IPF should also be investigated.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Medicine, General & Internal
Toby M. Maher, Paul Ford, Kevin K. Brown, Ulrich Costabel, Vincent Cottin, Sonye K. Danoff, Irene Groenveld, Eric Helmer, R. Gisli Jenkins, Julie Milner, Geert Molenberghs, Bjorn Penninckx, Matthew J. Randall, Bernt Van den Blink, Ann Fieuw, Charlotte Vandenrijn, Sanda Rocak, Ineke Seghers, Lixin Shao, Amit Taneja, Garrit Jentsch, Timothy R. Watkins, Wim A. Wuyts, Michael Kreuter, Nadia Verbruggen, Niyati Prasad, Marlies S. Wijsenbeek
Summary: This study aimed to assess the efficacy and safety of the autotaxin inhibitor ziritaxestat in patients with idiopathic pulmonary fibrosis (IPF). The study found that ziritaxestat did not improve clinical outcomes compared with placebo in patients with IPF.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Letter
Respiratory System
Maria Molina-Molina, Jessica Germaine Shull, Vanesa Vicens-Zygmunt, Pilar Rivera-Ortega, Katerina Antoniou, Francesco Bonella, Elisabetta Renzoni, Anne-Marie Russell, Toby M. Maher, Ada Vancheri, Anna Bachs, Victoria Aviles, Josep Palma, Guadalupe Bermudo, Guillermo Suarez-Cuartin, Cristian Tebe, Raul Rigo-Bonnin, Ana Montes-Worboys, Marlies Wijsenbeek, Carlo Vancheri
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Oncology
Chiara Herzog, Allison Jones, Iona Evans, Michal Zikan, David Cibula, Nadia Harbeck, Nicoletta Colombo, Angelique Floeter Radestad, Kristina Gemzell-Danielsson, Nora Pashayan, Martin Widschwendter
Summary: By analyzing DNA methylation and single nucleotide polymorphisms in cervical and breast tissues, it was found that a linear combination of methylation levels at breast cancer-associated methylation quantitative trait loci (mQTL) can be used to identify women with breast cancer. This method can be influenced by non-genetic risk factors and can be modified by preventive pharmacological intervention.
NPJ PRECISION ONCOLOGY
(2023)
Article
Respiratory System
Luca Richeldi, Arata Azuma, Vincent Cottin, Michael Kreuter, Toby M. Maher, Fernando J. Martinez, Justin M. Oldham, Claudia Valenzuela, Maud Gordat, Yi Liu, Susanne Stowasser, Donald F. Zoz, Marlies S. Wijsenbeek
Summary: This article describes a pivotal phase III study of a novel treatment for idiopathic pulmonary fibrosis (IPF). The study examines the efficacy of an oral phosphodiesterase 4B inhibitor, BI 1015550, in preventing a decline in forced vital capacity (FVC) in patients with IPF. The primary endpoint of the trial is the absolute change in FVC at week 52, while the key secondary endpoint is a composite of time to first IPF exacerbation, hospitalization due to respiratory cause or death.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Article
Respiratory System
Michael Kreuter, Elisabeth Bendstrup, Stephane Jouneau, Toby M. Maher, Yoshikazu Inoue, Corinna Miede, Dirk Lievens, Bruno Crestani
Summary: This study analyzed the relationship between baseline BMI and weight change and outcomes in patients with pulmonary fibrosis. The results showed that lower BMI and weight loss were associated with worse prognosis, indicating the need for measures to prevent weight loss.
RESPIRATORY RESEARCH
(2023)
Article
Respiratory System
Peter Saunders, Zhe Wu, William A. Fahy, Iain D. Stewart, Gauri Saini, David J. F. Smith, Rebecca Braybrooke, Carmel Stock, Elisabetta A. Renzoni, Simon R. Johnson, R. Gisli Jenkins, Maria G. Belvisi, Jaclyn A. Smith, Toby M. Maher, Philip L. Molyneaux
Summary: This study aims to assess the burden of cough and its impact on quality of life in newly diagnosed IPF patients. The results indicate that cough burden in IPF is high, but cough-specific quality of life does not have prognostic value and is not associated with MUC5B promoter polymorphism.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Meeting Abstract
Respiratory System
Toby M. Maher, Thomas Sciascia, Enoch Bortey, Philip L. Molyneaux, Marlies Wijsenbeek, Jaclyn Smith