Article
Multidisciplinary Sciences
Junli Zhuang, Hua Zhu, Ziqi Cheng, Xinyao Hu, Xiaohui Yu, Jie Li, Huagang Liu, Peng Tang, Ying Zhang, Xiaoxing Xiong, Hongping Deng
Summary: The study aimed to investigate the potential role of PCSK9 in the neck of AAA. Through bioinformatics methods, it was found that PCSK9 was highly expressed in the proximal neck of human AAA and may exert its role through interacting with immune check-points and ferroptosis-related genes.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hsin-Ying Lu, Hung-Lung Hsu, Chih-Han Li, Shao-Jung Li, Shing-Jong Lin, Chun-Ming Shih, Chun-Che Shih
Summary: Research suggests that H2S may inhibit the formation of AD by reducing inflammatory response, oxidative stress, and positively participating in vascular remodeling. These findings provide evidence for H2S as a novel and promising therapeutic strategy to prevent the development of AD.
Article
Nutrition & Dietetics
Sui-Shane Huang, Rongle Liu, Shufu Chang, Xiao Li, Xinyu Weng, Junbo Ge
Summary: This study reveals that the administration of Indole-3-aldehyde (3-IAId) significantly mitigates aortic dissection and rupture rates, leading to a notable reduction in mortality rates. Furthermore, it inhibits the phenotype transition of vascular smooth muscle cells, attenuates extracellular matrix degradation, suppresses macrophage infiltration, and reduces the expression of inflammatory cytokines, collectively contributing to the attenuation of AD development.
Article
Nutrition & Dietetics
Lin Zhu, Peng An, Wenting Zhao, Yi Xia, Jingyi Qi, Junjie Luo, Yongting Luo
Summary: Low zinc can reduce the development of thoracic aortic dissection triggered by vascular inflammation. It achieves this by reducing the infiltration of macrophages, inhibiting the expression of inflammatory cytokines, suppressing the phenotype switch of vascular smooth muscle cells, and ultimately improving the progression of thoracic aortic dissection.
Review
Pharmacology & Pharmacy
Yue Chen, Yi He, Xiang Wei, Ding-Sheng Jiang
Summary: This review focuses on the role of regulated cell death in the development of aortic aneurysm and dissection (AAD). Studies have shown that the death of smooth muscle cells, endothelial cells, and inflammatory cells is involved in the progression of AAD, and interventions targeting cell death can alleviate the disease.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xi Yang, Ling Chen, Ke-Yuan Chen, Qiu-Ying Zou, Jiang-Bin Wu, Liang-Wan Chen
Summary: This study investigates the role of adipose-derived mesenchymal stem cell (AMSC) exosomes and microRNA-222 (miR-222) in the progression of aortic dissection (AD). The results show that exosomes from AMSCs can reduce excessive proliferation and inflammation in AD by targeting the GNAI3-ERK signaling pathway. In vivo testing demonstrates that exosomic-miR-222 can lower the prevalence of AD and improve fibrosis levels in the aorta. These findings suggest that exosomic-miR-222 may have therapeutic potential in reducing sudden adverse episodes of AD.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biotechnology & Applied Microbiology
Xuelin Zhang, Yang Che, Lin Mao, Dandan Li, Jianqing Deng, Yilong Guo, Quanyi Zhao, Xingzhong Zhang, Li Wang, Xiang Gao, Yinan Chen, Tao Zhang
Summary: This study reveals the important role of histone variant H3.3B in aortic dissection by regulating gene expression and influencing the phenotype transition of vascular smooth muscle cells.
Review
Biochemistry & Molecular Biology
Xiancan Wang, Xianghai Kong, Xin Feng, Ding-Sheng Jiang
Summary: Ferroptosis is a type of programmed cell death characterized by increased levels of ferrous ions and lipid peroxidation. It has been found to play a role in various organ injuries and degenerative diseases, while insufficient ferroptosis has been linked to tumorigenesis. The regulatory mechanisms of ferroptosis involve iron metabolism, redox systems, and epigenetic mechanisms. This review provides a critical analysis of the molecular mechanisms and regulatory networks of ferroptosis, with a focus on the role of DNA, RNA, and protein methylation. The unanswered questions and debated findings in this field are also discussed.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Genetics & Heredity
Yingchao Zhou, Lingfeng Zha, Jianfei Wu, Mengru Wang, Mengchen Zhou, Gang Wu, Xiang Cheng, Zhengrong Huang, Qiang Xie, Xin Tu
Summary: This study investigates the involvement of mediator complex subunit 12 (MED12/Med12) in aortic dissection (AD) and reveals its mechanism through the TGF beta signaling pathway. The downregulation of Med12 inhibits proliferation and promotes senescence of mouse aortic smooth muscle cells (MOVAS), suggesting its potential as a new target for AD prevention and treatment.
Article
Pharmacology & Pharmacy
Min Li, Gang Li, Yanyan Yang, Jinbao Zong, Xiuxiu Fu, Aung Lynn Htet Htet, Xiaolu Li, Tianxiang Li, Jianxun Wang, Tao Yu
Summary: This study reveals that piR-823 is highly expressed in patients with AD and promotes the proliferation, migration, and phenotypic transformation of VSMCs. piR-823 exerts its regulatory role on VSMCs and AD by binding and suppressing HDAC1 expression and modulating histone 3 acetylation. In an AD mouse model, piR-823 antagomir effectively inhibits the pathogenesis of AD through regulating vascular remodeling.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Hematology
Huan Yang, Ting Zhou, Amelia Stranz, Elise DeRoo, Bo Liu
Summary: A study using single-cell RNA sequencing on mouse AAA tissues revealed 12 distinct populations of 8 cell types. The percentages of each population and gene expression were compared between sham and AAA tissue, showing that populations within major cell types such as smooth muscle cells, fibroblasts, and macrophages may contribute differently to AAA pathogenesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Surgery
Frank M. Davis, Lam C. Tsoi, Feiyang Ma, Rachael Wasikowski, Bethany B. Moore, Steven L. Kunkel, Johann E. Gudjonsson, Katherine A. Gallagher
Summary: This study provides the first comprehensive evaluation of the single-cell composition of abdominal aortic aneurysm (AAA) tissues and reveals how the gene expression landscape is altered in human AAAs. The study identified distinct transcriptional profiles of immune cells in AAAs compared to controls, as well as multiple pathways expressed only in AAA tissues. Additionally, it determined that the expression of SORT1 in vascular smooth muscle cells is critical for maintaining normal aortic wall function.
Article
Cell Biology
Chengxin Zhang, Kaiyuan Niu, Meixia Ren, Xinmiao Zhou, Zhisheng Yang, Mei Yang, Xinxin Wang, Jun Luo, Yue Shao, Cheng Zhang, Dan Chen, Shan Gao, Shenglin Ge, Qingchen Wu, Qingzhong Xiao
Summary: This study reveals the important role of MMP8 in aortic dissection (AD). Knockout of MMP8 can significantly reduce the incidence of AD and aortic elastin fragmentation. The study also further uncovers the involvement of MMP8, Ang II/VCAM1, and Ang II/ROS signaling pathways in the pathogenesis of AD.
Article
Genetics & Heredity
Cheng Xu, Xiaowei Liu, Xiaoxin Fang, Lei Yu, Hui Chong Lau, Danlei Li, Xiaoman Liu, Haili Li, Justin Ren, Baohui Xu, Jianjun Jiang, Lijiang Tang, Xiaofeng Chen
Summary: This study utilizes single-cell RNA sequencing technology to reveal the cellular composition and heterogeneity of smooth muscle cells (SMCs) in experimental aortic dissection (AD). The study identified 15 cell clusters and 9 cell types, showing significant changes in the relative numbers of SMCs and identifying 7 core differentially expressed genes (DEGs) in SMCs. The study also found that SMCs can differentiate into 8 different subtypes.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Yun-yun Yang, Xiao-lu Jiao, Hua-hui Yu, Lin-yi Li, Juan Li, Xiao-ping Zhang, Yan-wen Qin
Summary: This study found that serum Angiopoietin-Like Protein 8 (ANGPTL8) was associated with the diameter and rupture rate of thoracic aortic aneurysm/dissection (TAAD). The study demonstrated that ANGPTL8 can promote TAAD development by inducing endoplasmic reticulum stress activation and degradation of extracellular matrix. Therefore, inhibition of ANGPTL8 may represent a new strategy for TAAD therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)