Article
Oncology
Leifeng Liang, Qingwen Huang, Mei Gan, Liujun Jiang, Haolin Yan, Zhan Lin, Haisheng Zhu, Rensheng Wang, Kai Hu
Summary: The study revealed that SEC61G is significantly overexpressed in HNSCC tissues, and its high expression is significantly correlated with various clinicopathologic features. ROC curves demonstrated the significant diagnostic ability of SEC61G for HNSCC. Kaplan-Meier survival analysis showed that HNSCC patients with high SEC61G expression had a poorer prognosis. Multivariate analysis indicated that SEC61G is independently associated with overall survival. Function enrichment analysis suggested that SEC61G is involved in pathways related to translation and regulation of SLITs/ROBOs expression, which may impact HNSCC progression and prognosis.
Article
Oncology
Tobias Jagomast, Christian Idel, Luise Klapper, Patrick Kuppler, Anne Offermann, Eva Dreyer, Karl-Ludwig Bruchhage, Julika Ribbat-Idel, Sven Perner
Summary: This study investigated the clinical implications of CDK7 and pMED1 as potential biomarkers in head and neck squamous-cell cancer (HNSCC). The results showed that high levels of CDK7 were associated with lower survival rates and disease-free survival rates in HNSCC patients. Additionally, CDK7 expression was significantly elevated in immune cell infiltrated tumors. In vitro studies also demonstrated the potential of CDK7 inhibition as a therapeutic target.
Article
Immunology
Xinwen Wang, Shouwu Wu, Feng Liu, Dianshan Ke, Xinwu Wang, Dinglong Pan, Weifeng Xu, Ling Zhou, Weidong He
Summary: By identifying ICD-associated subtypes, a new classification system based on ICD signatures can be established in HNSCC patients, which helps in assessing prognosis and effectiveness of immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Fang Wang, Wenhao Zhang, Ying Chai, Hanshao Wang, Zhonglong Liu, Yue He
Summary: This study constructed a radiomics model to predict the expression level of CD27 in patients with head and neck squamous cell carcinoma (HNSCC). The study explored the potential molecular mechanisms underlying CD27 expression and its relationship with the immune microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wenying Zhu, Zhipeng Ye, Ling Chen, Haifeng Liang, Qian Cai
Summary: This study identified a potential clinical value of pyroptosis-related long non-coding RNAs in head and neck squamous cell carcinoma. The lncRNA signature consisting of 14 pyroptosis-related long non-coding RNAs could serve as a prognostic marker for HNSCC, suggesting pyroptosis as a promising therapeutic target in this type of cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yuanyuan Xu, Min Hong, Deyu Kong, Jun Deng, Zhaoming Zhong, Jin Liang
Summary: This study establishes a novel ferroptosis-related DNA methylation signature that can serve as a predictive tool for prognosis in patients with HNSCC.
Article
Oncology
Nicole N. Scheff, Alexandria L. Harris, Jinhong Li, Nicole L. Horan, Mark W. Kubik, Seungwon W. Kim, Marci L. Nilsen
Summary: This study examined the prevalence and predictors of perineural invasion (PNI) in head and neck cancer (HNC) patients, stratified by tumor site. The results showed that PNI was associated with pretreatment pain and tumor stage, highlighting the importance of considering tumor location in investigating targeted therapies for tumor regression.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Mingzhu Zhou, Mingyu Mao, Fan Yang, Tao Zhou, Liuqing Zhou, Yuncheng Li
Summary: This study identified lncRNA AL161431.1 as a reliable prognostic marker for head and neck squamous cell carcinoma (HNSCC), as its high expression correlated with poor survival. Functional enrichment analysis suggested that AL161431.1 may play a role in tumor development and the tumor microenvironment. Further analysis demonstrated a positive association between AL161431.1 expression and M0 macrophage infiltration in HNSCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xiwang Zheng, Defei Zheng, Chunming Zhang, Huina Guo, Yuliang Zhang, Xuting Xue, Zhaohui Shi, Xiangmin Zhang, Xianhai Zeng, Yongyan Wu, Wei Gao
Summary: This study analyzed the expression pattern, clinical correlation, DNA methylation, functional enrichment, and immune effects of cuproptosis-related lncRNAs (CRLs) in head and neck squamous cell carcinoma (HNSCC). A four-CRL signature was constructed using the LASSO algorithm, which showed potential for prognosis prediction in HNSCC. Functional analysis revealed enrichment of cell cycle, DNA replication, and p53 signal pathways. Therefore, targeting CRLs may be a promising therapeutic strategy for HNSCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Junjun Chen, Tianzhu Lu, Fangyan Zhong, Qiaoli Lv, Min Fang, Ziwei Tu, Yulong Ji, Jingao Li, Xiaochang Gong
Summary: This study aimed to construct a signature of N-6-methyladenosine (m6A) regulator-related genes for the prognosis of HNSCC. The study showed that the signature could effectively predict the prognosis of HNSCC patients and was related to immune cell infiltration and the response to ICI therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ruoyan Cao, Weilin Zhang, Hongjian Zhang, Lixuan Wang, Xijuan Chen, Xianyue Ren, Bin Cheng, Juan Xia
Summary: The peroxidase family of peroxiredoxins (PRDXs) plays a vital role in maintaining the intracellular balance of ROS in head and neck squamous cell carcinoma (HNSCC). The expression of PRDX1, PRDX4, and PRDX5 in HNSCC is increased, while the expression of PRDX2 is decreased. Higher expression of PRDX4/5/6 indicates poor prognosis, while lower expression of PRDX1/5 is associated with more immune cell infiltration, higher expression of immune-related molecules, and a likely response to anti-PD-1 treatment. Knockdown of PRDX5 inhibits HNSCC cell proliferation, invasion, and metastasis, and promotes apoptosis through its antioxidant property. This study highlights the potential role of PRDXs, particularly PRDX5, in HNSCC and suggests it as a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Torben Wilms, Linda Boldrup, Xiaolian Gu, Philip J. Coates, Nicola Sgaramella, Karin Nylander
Summary: This study revealed that high LDL levels are beneficial for survival outcome in patients with squamous cell carcinoma of the head and neck. Patients with high levels of total cholesterol or LDL had better overall survival. High LDL was identified as an independent prognostic factor for overall and disease-free survival.
Article
Genetics & Heredity
Ruoyan Cao, Suyang Liu, Jiayu Zhang, Xianyue Ren, Xijuan Chen, Bin Cheng, Juan Xia
Summary: TP53INP2 expression is lower in head and neck squamous cell carcinoma, and higher expression is associated with longer survival. It is involved in DNA replication, repair, cell cycle, and metabolic pathways. TP53INP2 may affect the expression of multiple genes through enhancing the transcriptional activity of nuclear hormone receptors.
FRONTIERS IN GENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Zeng-Hong Wu, Yi Zhong, Tao Zhou, Hong-Jun Xiao
Summary: The study used RNA sequencing and miRNA sequencing data to reveal the dysfunctional miRNAs microenvironment in head and neck squamous cell carcinoma and provide useful biomarkers for miRNAs therapy. By predicting the target genes of miRNAs, nine genes correlated with patient's overall survival outcomes were identified.
Article
Oncology
Tianzhu Lu, Yahan Zheng, Xiaochang Gong, Qiaoli Lv, Junjun Chen, Ziwei Tu, Shaojun Lin, Jianji Pan, Qiaojuan Guo, Jingao Li
Summary: The study found that HMMR is highly expressed in HNSCC tumor tissue, and high HMMR mRNA expression is an independent prognostic factor in TCGA and GSE41613 data. The methylation level of HMMR is negatively correlated with its expression, with patients having low methylation levels showing worse overall survival. HMMR may be associated with biological functions related to the KARS, EMT, and G2M checkpoint pathways, interferon-gamma, and interferon-alpha responses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jaffer A. Ajani, Yan Xu, Longfei Huo, Ruiping Wang, Yuan Li, Ying Wang, Melissa Pool Pizzi, Ailing Scott, Kazuto Harada, Lang Ma, Xiaodan Yao, Jiankang Jin, Wei Zhao, Xiaochuan Dong, Brian D. Badgwell, Namita Shanbhag, Ghia Tatlonghari, Jeannelyn Santiano Estrella, Sinchita Roy-Chowdhuri, Makoto Kobayashi, Jody V. Vykoukal, Samir M. Hanash, George Adrian Calin, Guang Peng, Ju-Seog Lee, Randy L. Johnson, Zhenning Wang, Linghua Wang, Shumei Song
Summary: YAP1 is highly upregulated in peritoneal carcinomatosis tumor cells, contributing to cancer stem cell properties and metastasis. Inhibition of YAP1 can significantly slow tumor growth and eliminate peritoneal carcinomatosis in preclinical models. Pharmacological inhibition of YAP1 can reduce cancer stem cell-like properties and suppress tumor growth, especially in combination with cytotoxic drugs in vivo models.
Article
Gastroenterology & Hepatology
Changyu Zhu, Yu-Jui Ho, Marcela A. Salomao, Dianne H. Dapito, Alberto Bartolome, Robert F. Schwabe, Ju-Seog Lee, Scott W. Lowe, Utpal B. Pajvani
Summary: The study revealed that Notch activity characterizes a distinct molecular subtype of HCC in humans, associated with unique histology and prognosis. Sustained Notch signaling in chronic liver diseases can drive tumor formation without acquiring specific genomic driver mutations.
JOURNAL OF HEPATOLOGY
(2021)
Article
Otorhinolaryngology
Su Il Kim, Hye Kyu Min, Dae Woong Kang, Soo Young Choi, Hee Jin Kang, Young Chan Lee, Young-Gyu Eun, Seong-Gyu Ko
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Jeong Wook Kang, Jung Min Park, Young Chan Lee, Young-Gyu Eun
Summary: This study evaluated the prevalence of insomnia in patients with laryngopharyngeal reflux (LPR) and found that LPR patients were more likely to experience insomnia, and the severity of reflux symptoms was correlated to the severity of insomnia.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
Su Il Kim, Seon Rang Woo, Joo Kyung Noh, Min Kyeong Lee, Young Chan Lee, Jung Woo Lee, Seong-Gyu Ko, Young-Gyu Eun
Summary: The FAT1 gene has both tumor suppressor and promoter functions in head and neck squamous cell carcinoma (HNSCC). Research has shown that the FAT1 gene signature is associated with prognosis, response to radiotherapy, advanced stage, and human papilloma virus (HPV) status in HNSCC patients.
MOLECULAR ONCOLOGY
(2022)
Letter
Otorhinolaryngology
Jeong Wook Kang, Jung Min Park, Young Chan Lee, Young-Gyu Eun
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
Soo-Mi Kweon, Gayeoun Kim, Yunseong Jeong, Wendong Huang, Ju-Seog Lee, Keane K. Y. Lai
Summary: Liver cancer, one of the deadliest cancers, may be influenced by the little-known gene midnolin, which has been found to correlate with poor prognosis in patients and may have a significant impact on liver cancer development.
Article
Medicine, Research & Experimental
Jerome R. Lechien, Quentin Lisan, Claudia A. Eckley, Abdul-Latif Hamdan, Young-Gyu Eun, Stephane Hans, Sven Saussez, Lee M. Akst, Thomas L. Carroll
Summary: This study investigated the clinical patterns and disease evolution of laryngopharyngeal reflux (LPR) patients. Baseline quality of life score was found to predict the clinical course of LPR patients, and a novel classification system was proposed. This study is of importance for understanding and treating LPR patients.
Article
Oncology
Soo-Young Choi, Hyeon-Kyoung Cheong, Min-Kyeong Lee, Jeong-Wook Kang, Young-Chan Lee, In-Hwan Oh, Young-Gyu Eun
Summary: The development of head and neck cancer is influenced by metabolic diseases. Obesity reduces the risk of HNC in men, while underweight and diabetes are risk factors for both men and women. High cholesterol and LDL levels decrease the risk in men. Each metabolic disease affects HNC differently.
Article
Oncology
Joo Kyung Noh, Seon Rang Woo, Moonkyoo Kong, Min Kyeong Lee, Jung Woo Lee, Young Chan Lee, Seong-Gyu Ko, Young-Gyu Eun
Summary: This study developed accurate prognostic predictors for oral squamous cell carcinoma (OSCC) and investigated the underlying biology. A gene signature related to OSCC recurrence was identified, and oxidative phosphorylation (OXPHOS) pathway was shown to be associated with poor prognosis in OSCC.
MOLECULAR ONCOLOGY
(2023)
Article
Otorhinolaryngology
Jeong Wook Kang, Young Chan Lee, Seong-Gyu Ko, Young-Gyu Eun
Summary: The objective of this study was to analyze the incidence of pharyngeal reflux in laryngopharyngeal reflux (LPR) patients over a 24-hour period and determine the key timing of pharyngeal reflux. A total of 69 LPR patients were monitored using 24-hour multichannel intraluminal impedance-pH (24hr MIIpH) monitoring, and quantitative analysis was performed on the LPR profiles. The results revealed that pharyngeal reflux mainly occurred during the day in the upright position, with the most frequent timing being within 2 hours after meals. There was no significant difference in post-prandial reflux timing between LPR patients and asymptomatic controls.
AURIS NASUS LARYNX
(2023)
Article
Oncology
Joann Jung, Sowon Park, Yeonwoo Jang, Sung-Hwan Lee, Yun Seong Jeong, Sun Young Yim, Ju-Seog Lee
Summary: Hepatocellular carcinoma (HCC) is a common cancer that causes a large number of deaths worldwide. Metabolic reprogramming is a key feature of HCC, allowing cancer cells to meet the high energy demands for fast growth. By comparing genomic data from mice and humans, we identified three distinct metabolic subtypes of HCC and found clinical and molecular characteristics associated with each subtype. Notably, we discovered that the high metabolic subtype is resistant to immunotherapy and uncovered a potential mechanism for this resistance.
Letter
Gastroenterology & Hepatology
Sun Young Yim, Ju-Seog Lee
Article
Oncology
Jeong Wook Kang, Hyeon-Kyoung Cheong, Su Il Kim, Min Kyeong Lee, Young Chan Lee, In-Hwan Oh, Young-Gyu Eun
Summary: The incidence of hypopharyngeal cancer is increasing, but early diagnosis and prevention are important for better management. Metabolic syndrome is inversely associated with the risk of hypopharyngeal cancer, especially in women.
Article
Otorhinolaryngology
Jeong Wook Kang, Min Kyeong Lee, Young Chan Lee, Seong-gyu Ko, Young-Gyu Eun
Summary: This study aimed to evaluate the relationship between laryngopharyngeal reflux (LPR) and anxiety. The results showed that patients with LPR were more likely to experience somatic anxiety symptoms compared to healthy individuals.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2023)
