A pyroptosis-related lncRNA signature predicts prognosis and immune microenvironment in head and neck squamous cell carcinoma

LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia

(2021) Li-Qing Wang et al.   MOLECULAR MEDICINE

Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis

(2021) Michael W Knitz et al.   Journal for ImmunoTherapy of Cancer

A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer

(2021) Ying Ye et al.   Cell Death Discovery

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

(2021) Jing Cai et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis

(2020) Yanling Niu et al.   CANCER RESEARCH

lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling

(2020) Jinchang Pan et al.   Molecular Cancer

Mechanism and regulation of pyroptosis-mediated in cancer cell death

(2020) Jianwei Ruan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Long non‑coding RNA SNHG7 inhibits NLRP3‑dependent pyroptosis by targeting the miR‑34a/SIRT1 axis in liver cancer

(2020) Zhaohong Chen et al.   Oncology Letters

LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis

(2020) Niansheng Ren et al.   Aging-US

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

A Gene Mutation Signature Predicting Immunotherapy Benefits in Patients With NSCLC

(2020) Dong Pan et al.   Journal of Thoracic Oncology

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

Multifactorial Contribution of Notch Signaling in Head and Neck Squamous Cell Carcinoma

(2019) Cristina Porcheri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro

(2019) Pian Yu et al.   ACTA PHARMACOLOGICA SINICA

Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis

(2019) Lu Wang et al.   CANCER LETTERS

Epidemiology of Head and Neck Squamous Cell Carcinomas: Impact on Staging and Prevention Strategies

(2019) Jessica D. McDermott et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

(2019) Francesca Finotello et al.   Genome Medicine

The changing therapeutic landscape of head and neck cancer

(2019) John D. Cramer et al.   Nature Reviews Clinical Oncology

Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death

(2019) Jinglei Liu et al.   Aging-US

GSDMD is required for effector CD8+ T cell responses to lung cancer cells

(2019) Guangmin Xi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TMPO‐AS1 promotes cervical cancer progression by upregulating RAB14 via sponging miR‐577

(2019) Jian Yang et al.   JOURNAL OF GENE MEDICINE

Immuno-radiotherapy with cetuximab and avelumab for advanced stage head and neck squamous cell carcinoma: Results from a phase-I trial

(2019) Joris B.W. Elbers et al.   RADIOTHERAPY AND ONCOLOGY

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

(2019) David Liu et al.   NATURE MEDICINE

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

(2019) Dan A. Erkes et al.   Cancer Discovery

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The novel regulatory role of lncRNA-miRNA-mRNA axis in cardiovascular diseases

(2018) Ying Huang   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ensembl 2019

(2018) Fiona Cunningham et al.   NUCLEIC ACIDS RESEARCH

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis

(2017) Alexandra Snyder et al.   PLOS MEDICINE

Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data

(2017) Julien Racle et al.   eLife

Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway

(2016) Xiaomin Ma et al.   Oncotarget

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE