Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation

Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities

(2014) Ryan J. Davis et al.   CANCER CELL

Mutation Profiling in Cholangiocarcinoma: Prognostic and Therapeutic Implications

(2014) Chaitanya R. Churi et al.   PLoS One

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

(2013) Bryan King et al.   CELL

Investigation of the atypicalFBXW7mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

(2013) Hayley Davis et al.   GUT

CDC4/FBXW7 and the ‘just enough’ model of tumourigenesis

(2012) Hayley Davis et al.   JOURNAL OF PATHOLOGY

Production of mouse pups from germline transmission-failed knockout chimeras

(2012) Yoshitaka Fujihara et al.   TRANSGENIC RESEARCH

Emerging roles of the FBW7 tumour suppressor in stem cell differentiation

(2011) Zhiwei Wang et al.   EMBO REPORTS

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development

(2011) Hayley Davis et al.   JOURNAL OF PATHOLOGY

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

The Fbw7 Tumor Suppressor Targets KLF5 for Ubiquitin-Mediated Degradation and Suppresses Breast Cell Proliferation

(2010) Dong Zhao et al.   CANCER RESEARCH

The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs

(2010) Ning Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

(2010) Ichiro Onoyama et al.   JOURNAL OF CLINICAL INVESTIGATION

FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

(2008) Jian-Hua Mao et al.   SCIENCE