Journal
RSC ADVANCES
Volume 8, Issue 43, Pages 24322-24327Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ra03185a
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Funding
- Mid-career Researcher Support Program of the National Research Foundation (NRF) - Ministry of Science and ICT (MSIT) of Korea [2018R1A2A1A05022355]
- BioNano Health-Guard Research Center - MSIT of Korea as Global Frontier Project [H-GUARD_2013M3A6B2078964]
- Basic Science Research Program - Bio-Synergy Research Project of the MSIP through the NRF [NRF-2015M3A9C4070484]
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We herein describe a rapid and selective sensing platform for tetracycline (Tc), which relies on the metal-enhanced fluorescence (MEF) effect of europium (Eu3+)-doped silver-silica core-shell nanoparticles (AgNP@SiO2). The developed assay utilizes AgNP@SiO2 as a key detection component, which is systematically optimized to have a silica shell thickness suitable for the effective MEF phenomenon. In principle, the AgNP@SiO2, which binds to Eu3+ through the electrostatic interaction, captures Tc by selective chelation with Eu3+, leading to significant fluorescence enhancement of the EuTc complex. Based on this novel strategy, we determined Tc as low as 83.1 nM with a total assay time of less than 10 min, which is comparable to or better than that of the previous fluorescence-based methods. Furthermore, the practical applicability of this strategy was successfully demonstrated by detecting Tc in tap water. This work highlights the unique features of AgNP@SiO2 for MEF-based biosensing applications.
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