Article
Biochemistry & Molecular Biology
Daniela Marasco, Caterina Vicidomini, Pawel Krupa, Federica Cioffi, Pham Dinh Quoc Huy, Mai Suan Li, Daniele Florio, Kerensa Broersen, Maria Francesca De Pandis, Giovanni N. Roviello
Summary: Different isoquinoline alkaloids exhibit varying effects on beta-amyloid aggregation, with some compounds showing inhibitory effects and others showing promoting effects. Experimental results suggest that these compounds have the potential to serve as starting leads for the development of therapeutic strategies in neurodegenerative diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Jiaqi Zuo, Engao Zhu, Wenjing Yin, Chuangye Yao, Jiajia Liao, Xinni Ping, Yuqing Zhu, Xuting Cai, Yuchun Rao, Hui Feng, Kewei Zhang, Zhaosheng Qian
Summary: Fluorescent probes are valuable tools for visualizing plasma membranes and their related physiological processes in a spatiotemporal manner. However, there is a lack of probes for long-term imaging of plant cell membranes. In this study, we designed an AIE-active probe with NIR emission that allows for four-dimensional spatiotemporal imaging of plant cell membranes. The probe showed excellent specificity and long imaging times, making it a valuable tool for monitoring dynamic processes of plasma membrane-related events.
Article
Chemistry, Analytical
Hongying Jia, Lei Yang, Xue Dong, Limin Zhou, Qin Wei, Huangxian Ju
Summary: This study proposed a strategy to improve the ECL performance of Au nanoclusters by introducing L-Cys, which limits the intramolecular motion and nonradiative relaxation of the excited state. Triethylamine was used as a coreactant to further enhance the ECL performance.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Maryam F. Abdollahi, Jian You, Tao Wang, Yuming Zhao
Summary: The absorption and emission properties of various diphenyl-dibenzofulvene (DP-DBF) derivatives were found to correlate with the twist angle around the C=C bond of the DP-DBF structure, indicating a clear relationship with their crystallization-induced emission enhancement (CIEE) performances.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Shakil Ahmed, Prodip Howlader, Soumalya Bhattacharyya, Surajit Mondal, Ennio Zangrando, Partha Sarathi Mukherjee
Summary: This study investigates the enhancement of emission of aggregation-induced emission (AIE)-active molecules in dilute solution by restricting intramolecular motion (RIM). A Pd-4 molecular vessel (MP1) was assembled to restrict the active intramolecular motions of AIE active molecule SG. SG showed significant enhancement in emission in dilute solution upon addition of MP1. This strategy has the potential to design materials for high emission in the aggregated state as well as in dilute solution.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Feifei Su, Xianchao Du, Ting Shen, Anjun Qin, Weihua Li
Summary: This research developed a novel aggregation-induced emission luminogen (AIEgen) applied in epoxy coating for visualizing early metal corrosion detection through a fluorescent 'Turn-On' phenomenon. The coating showed excellent luminescence response with only 0.5 parts per thousand TPM content and rapid and convenient corrosion detection was achieved through a visible fluorescent 'Turn-On' phenomenon. Additionally, the research discussed the fluorescent response mechanism and intramolecular charge transfer effect, providing insights into early metal corrosion detection based on AIEgens.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Materials Science, Multidisciplinary
Oguzhan Ustun, Sugra Naz Karadag, Hayrunnisa Mazlumoglu, Asli Yilmaz, Mehmet Yilmaz
Summary: Carbon quantum dots (CQDs) have been widely used in various fields due to their strong photoluminescence activity, high biocompatibility, robust stability, low cytotoxicity, and flexible surface structures. This study focused on investigating the pH-sensitive photoluminescence nature of boron/nitrogen co-doped CQDs (B/N CQDs), and provided significant progress in understanding their pH-dependent behavior.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Engineering, Biomedical
Lingbo Zhou, Luojia Chen, Sijie Chen, Zeyuan Pu, Meijia Gu, Yin Shen
Summary: This study reports a highly efficient photodynamic therapy for retinoblastoma using an aggregation-induced emission photosensitizer. The therapy selectively damages tumors, minimizes side effects on normal tissue, and provides protection against metastasis. The photosensitizer also reduces tissue inflammation and exhibits excellent biocompatibility.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Applied
Ze Yu, Yufeng Mao, Anqi Lv, Zhongfu An, Huili Ma
Summary: Organic fluorophores are crucial for organic optoelectronic and bioelectronic applications. The enhancement of fluorescence in bromo-organic aggregates, which breaks the traditional belief of heavy-atom effect leading to fluorescence quenching, is achieved by the limited acceleration of intersystem crossing process and the large reduction of vibronic coupling of singlet excitons caused by bromine atoms. The excited-state dynamics further demonstrate that bromine substituents decelerate the internal conversion process and result in slow ISC rates, leading to abnormal fluorescence enhancement.
Review
Biochemistry & Molecular Biology
Yue Yang, Ping-Ya He, Yi Zhang, Ning Li
Summary: Natural compounds are abundant sources of anticancer drugs, with significant antitumor effects through regulating mitochondria. Research on how natural products regulate mitochondria in recent years is valuable for the development of new anticancer drugs.
Article
Chemistry, Analytical
Shuwei Zhang, Ting Wang, Xuewen Wang, Wenyi Liao, Xinyao Wang, Yu Yuan, Gang Chen, Xiaodong Jia
Summary: In this study, a novel fluorescence probe TPE-DCP was developed for sensitive detection of intracellular pH changes, showing excellent performance and successful application in imaging intracellular pH changes in cells.
Article
Chemistry, Analytical
Qianhua Li, Wenlong Zhu, Shengyi Gong, Siyu Jiang, Guoqiang Feng
Summary: A viscosity-responsive plasma membrane probe (TPA-S) was developed and used to detect the viscosity difference between normal and tumor cell plasma membranes. The results showed that the plasma membrane of tumor cells is more viscous than that of normal cells, and TPA-S was successfully applied for tumor imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Geeta Kumari, Ajay Gupta, Raj Kumar Sah, Aryan Gautam, Monika Saini, Aashima Gupta, Akhilesh K. K. Kushawaha, Shailja Singh, Pijus K. K. Sasmal
Summary: A series of water-soluble cyclometalated iridium(III) polypyridyl complexes have been found to exhibit potent antimalarial activity against drug-resistant Plasmodium parasites. These complexes exert their antimalarial activity by increasing reactive oxygen species levels and disrupting the mitochondrial membrane potential of the parasites.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Qianrun Chen, Danhua Ruan, Jiayan Shi, Dongru Du, Ce Bian
Summary: Mitochondria are the primary source of cellular energy production and dysfunction is associated with various diseases. Natural products offer a new therapeutic opportunity for regulating dysfunctional mitochondria. Recent advances in targeting mitochondria and regulating mitochondrial dysfunction using natural products are summarized in this review. Mechanisms of natural products in modulating mitochondrial dysfunction and the future prospects and challenges in developing mitochondria-targeting natural products are discussed, highlighting their potential value in treating mitochondrial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2023)