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Biochemistry & Molecular Biology
Kyung-Hye Roh, Yeojin Lee, Je-Hyun Yoon, Danbi Lee, Eunju Kim, Eunchong Park, In Young Lee, Tae Sung Kim, Hyun Kyu Song, Jaekyoon Shin, Dae-Sik Lim, Eui-Ju Choi
Summary: MST1/STK4 acts as a negative regulator of the TLR4-NF-kappa B signaling pathway, inhibiting TRAF6 autoubiquitination and downstream signaling, thereby limiting inflammation induced by LPS. The research also suggests that MST1/STK4 can regulate the production of proinflammatory cytokines in macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
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Immunology
Jian Hu, Xue Wang, Xiongjian Chen, Yani Fang, Kun Chen, Wenshuo Peng, Zhengyi Wang, Kaiming Guo, Xianxi Tan, Fei Liang, Li Lin, Ye Xiong
Summary: The study found that hydroxychloroquine (HCQ) can improve neurological recovery in mice post-TBI by inhibiting the inflammatory response through the TLR4/NF-kappa B signaling pathway. HCQ reduces the expression of proinflammatory cytokines, attenuates blood-brain barrier (BBB) disruption and brain edema, and upregulates tight junction expression. This suggests that HCQ could be a potential therapeutic agent for TBI treatment.
JOURNAL OF NEUROINFLAMMATION
(2022)
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Dentistry, Oral Surgery & Medicine
Hao Chen, Yaqi Liu, Sijing Yu, Cheng Li, Bo Gao, Xuedong Zhou
Summary: This study aims to investigate the anti-inflammatory and osteoprotective effects of CBD in periodontitis and its molecular mechanisms. The results show that CBD significantly inhibits bone loss in experimental rat periodontitis models and reduces LPS-induced inflammation in human periodontal ligament cells (hPDLCs) by inhibiting TLR4/NF-kappa B pathway activation. Therefore, CBD can be considered as a therapeutic agent for periodontitis.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
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Immunology
Qiao Zhou, Ding-Xiu He, Yi-Ling Deng, Chun-Li Wang, Lan-Lan Zhang, Fa-Ming Jiang, Laurent Irakoze, Zong-An Liang
Summary: This study found that miR-124-3p has a protective effect on acute lung injury (ALI) by inhibiting the TLR4/NF-kappa B signaling pathway, and miR-124-3p directly targets PDE4B to suppress this signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
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Multidisciplinary Sciences
Yan Wang, Zhengzhao Li, Bo Wang, Ke Li, Jiaxuan Zheng
Summary: Naringenin, a flavonoid with multiple biological effects, was found to reverse IL-1(3-induced chondrocyte injury by inhibiting the TLR4/TRAF6/NF-xB pathway and alleviate pathological symptoms in a mouse model of osteoarthritis.
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Biochemistry & Molecular Biology
Zhongwen Zhi, Xiaohong Tang, Yuqian Wang, Rui Chen, Hu Ji
Summary: Sinensetin (SIN) attenuates A beta-induced neurotoxicity through the TLR4/NF-kappa B pathway.
NEUROCHEMICAL RESEARCH
(2021)
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Nutrition & Dietetics
Bingyong Mao, Weiling Guo, Xin Tang, Qiuxiang Zhang, Bo Yang, Jianxin Zhao, Shumao Cui, Hao Zhang
Summary: Inosine pre-treatment attenuates LPS-induced pulmonary inflammatory response by regulating the TLR4/MyD88/NF-kappa B signaling pathway and ameliorates intestinal microbiota disorder.
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Biochemistry & Molecular Biology
Boyu Yuan, Mingming Liu, Yuhong Gong, Zifan Wang, Xinxin Jin, Gaijie Xie, Mingqiang Zhu, Xue Zhang, Siyuan Luo, Qing Qu, Yufeng Zhu, Meng Wang, Yingli Jin, Bai Li, Wei Wang
Summary: This study evaluated the neuroprotective effect of sodium butyrate against A beta-induced neurotoxicity and found that sodium butyrate could enhance the expression of angiotensin-converting enzyme and brain-derived neurotrophic factor, thereby protecting neuronal cells from A beta-induced damage.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Neurosciences
Mingyue Fan, Zhe Li, Ming Hu, Haifeng Zhao, Tianjun Wang, Yanqiu Jia, Rui Yang, Shuo Wang, Jiaxi Song, Yang Liu, Wei Jin
Summary: The study shows that FMN can attenuate the inflammatory response in human brain microvascular endothelial cells induced by Aβ, and this effect is mediated at least in part through the Nrf2 pathway.
BRAIN RESEARCH BULLETIN
(2022)
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Pharmacology & Pharmacy
Yi Wei, Ming Qi, Chao Liu, Lujia Li
Summary: This study demonstrates that Astragalus polysaccharide (APS) has anti-inflammatory and antioxidant properties and can have beneficial effects on pulmonary fibrosis. APS ameliorates lung tissue injury by inhibiting the TLR4/NF-Kappa B signaling pathway, reducing inflammatory cytokine activation, and decreasing apoptosis. APS also regulates the metabolism of gut microbiota, restoring gut dysbiosis in the IPF mice model.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
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Environmental Sciences
Huajing Li, Hongmei Zhang, Hua Zhao
Summary: Apigenin alleviates the inflammatory response of allergic rhinitis by inhibiting the activity of the TLR4/MyD88/NF-kappa B signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
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Anatomy & Morphology
Qinhan Hou, Hongmou Chen, Quan Liu, Xianlei Yan
Summary: The overexpression of FGF10 can alleviate neurological deficits, neuronal apoptosis, and neuroinflammation in experimental TBI mice by inhibiting the TLR4/MyD88/NF-kappa B pathway, providing a potential therapeutic strategy for brain injury.
CELLS TISSUES ORGANS
(2021)
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Plant Sciences
Yuxin Dai, Qiulu Lu, Peiyi Li, Junyu Zhu, Jiaxin Jiang, Tong Zhao, Yue Hu, Kang Ding, Min Zhao
Summary: This study aimed to investigate the mechanism of Xianglian Pill (XLP) in treating ulcerative colitis (UC) induced by dextran sulfate sodium (DSS). The results showed that XLP treated UC by regulating the TLR4/MyD88/NF-kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
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Immunology
Zhen-Ni Liu, Xue Wu, Qian Fang, Zi-Xuan Li, Guo-Qing Xia, Jun-Nan Cai, Xiong-Wen Lv
Summary: This study found that overexpression of CD73 can reduce alcohol-induced liver injury and inflammation, suggesting CD73 as a potential therapeutic target for ALD.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
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Biochemistry & Molecular Biology
Santa Cirmi, Alessandro Maugeri, Caterina Russo, Laura Musumeci, Michele Navarra, Giovanni Enrico Lombardo
Summary: It has been found that Olea europaea, particularly its compound oleacein (OLC), exhibits anti-inflammatory activity by reversing the inflammatory response and reducing the release of pro-inflammatory cytokines. Additionally, OLC modulates inflammatory signaling pathways to exert its anti-inflammatory effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)