Journal
RSC ADVANCES
Volume 8, Issue 28, Pages 15444-15447Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ra02009d
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Funding
- NSFC [21572087, 21632003]
- Key program of Gansu province [17ZD2GC011]
- 111 program from the MOE of P. R. China
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A C-1-symmetric N-heterocyclic carbene (NHC)-catalysed activation of isatin-derived enals under oxidative conditions was achieved. The in situ generated alpha,beta-unsaturated acyl azolium species was efficiently trapped by 1,3-dicarbonyl compounds via a Michael addition/spiroannualtion cascade, delivering a series of synthetically important spirooxindole delta-lactones with up to 96% enantioselectivity.
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