A Review of the New Antiepileptic Drugs for Focal-Onset Seizures in Pediatrics: Role of Extrapolation

Extrapolating evidence of antiepileptic drug efficacy in adults to children ≥2 years of age with focal seizures: The case for disease similarity

(2017) John M. Pellock et al.   EPILEPSIA

Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years

(2017) Rik Schoemaker et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

(2017) Ingmar Blumcke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eslicarbazepine Acetate: A New Improvement on a Classic Drug Family for the Treatment of Partial-Onset Seizures

(2017) Graciana L. Galiana et al.   Drugs in research & development

Spotlight on perampanel in the management of seizures: design, development and an update on place in therapy

(2017) Michele A Faulkner   Drug Design Development and Therapy

New developments in the management of partial-onset epilepsy: role of brivaracetam

(2017) Giangennaro Coppola et al.   Drug Design Development and Therapy

Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation

(2016) Ian Wadsworth et al.   CNS DRUGS

Lacosamide use in children with epilepsy: Retention rate and effect of concomitant sodium channel blockers in a large cohort

(2016) Emily McGinnis et al.   EPILEPSIA

Adjunctive perampanel in adolescents with inadequately controlled partial-onset seizures: A randomized study evaluating behavior, efficacy, and safety

(2016) Lieven Lagae et al.   EPILEPSIA

Pharmacokinetics, exposure–cognition, and exposure–efficacy relationships of perampanel in adolescents with inadequately controlled partial-onset seizures

(2016) Vicente Villanueva et al.   EPILEPSY RESEARCH

Brivaracetam add-on for refractory focal epilepsy

(2016) Simona Lattanzi et al.   NEUROLOGY

Intravenous Lacosamide in Pediatric Status Epilepticus: An Open-Label Efficacy and Safety Study

(2016) Karan Poddar et al.   PEDIATRIC NEUROLOGY

Perampanel Serum Concentrations in Adults With Epilepsy

(2016) Philip N. Patsalos et al.   THERAPEUTIC DRUG MONITORING

The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2

(2016) Marianna Leonzino et al.   Cell Reports

GABAergic Synchronization in Epilepsy

(2016) Roustem Khazipov   Cold Spring Harbor Perspectives in Medicine

Form and Function of Sleep Spindles across the Lifespan

(2016) Brittany C. Clawson et al.   NEURAL PLASTICITY

Clinical Pharmacokinetic and Pharmacodynamic Profile of Lacosamide

(2015) Willi Cawello   CLINICAL PHARMACOKINETICS

A randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult patients with uncontrolled partial-onset seizures

(2015) Pavel Klein et al.   EPILEPSIA

Perampanel in the treatment of partial seizures: Time to onset and duration of most common adverse events from pooled Phase III and extension studies

(2015) David Ko et al.   EPILEPSY & BEHAVIOR

Efficacy and safety of perampanel in adolescent patients with drug-resistant partial seizures in three double-blind, placebo-controlled, phase III randomized clinical studies and a combined extension study

(2015) William Rosenfeld et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Pharmacokinetic/pharmacodynamic evaluation of eslicarbazepine for the treatment of epilepsy

(2015) Monika Banach et al.   Expert Opinion on Drug Metabolism & Toxicology

The efficacy and safety of brivaracetam at different doses for partial-onset epilepsy: a meta-analysis of placebo-controlled studies

(2015) Xin Tian et al.   EXPERT OPINION ON PHARMACOTHERAPY

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: A comparison with carbamazepine, oxcarbazepine and lacosamide

(2015) Simon Hebeisen et al.   NEUROPHARMACOLOGY

Specialization and integration of functional thalamocortical connectivity in the human infant

(2015) Hilary Toulmin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perampanel: A new agent for adjunctive treatment of partial seizures

(2014) M. A. Faulkner   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Advances in epilepsy treatment: lacosamide pharmacokinetic profile

(2014) Willi Cawello et al.   Annals of the New York Academy of Sciences

Off-Label Prescribing of Antiepileptic Drugs in Pharmacoresistant Epilepsy: A Cross-Sectional Drug Utilization Study of Tertiary Care Centers in Italy

(2014) Valentina Franco et al.   CNS DRUGS

Depolarizing GABA and Developmental Epilepsies

(2014) Roustem Khazipov et al.   CNS Neuroscience & Therapeutics

Brivaracetam Single and Multiple Rising Oral Dose Study in Healthy Japanese Participants: Influence of CYP2C19 Genotype

(2014) Armel Stockis et al.   Drug Metabolism and Pharmacokinetics

Perampanel for adjunctive treatment of partial-onset seizures: A pooled dose-response analysis of phase III studies

(2014) Lynn D. Kramer et al.   EPILEPSIA

Oscillatory Dynamics and Place Field Maps Reflect Hippocampal Ensemble Processing of Sequence and Place Memory under NMDA Receptor Control

(2014) Henrique O. Cabral et al.   NEURON

Efficacy and Tolerability of Lacosamide as an Adjunctive Therapy in Children With Refractory Partial Epilepsy

(2014) Ismail Pasha et al.   PEDIATRIC NEUROLOGY

Off-Label Prescribing in Pediatric Outpatients

(2014) A. Palmaro et al.   PEDIATRICS

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

(2014) R. Tyzio et al.   SCIENCE

Efficacy of perampanel: a review of clinical trial data

(2013) F. Kerling et al.   ACTA NEUROLOGICA SCANDINAVICA

Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist

(2013) M. A. Rogawski et al.   ACTA NEUROLOGICA SCANDINAVICA

Pediatric epilepsy genetics

(2013) Massimo Pandolfo   CURRENT OPINION IN NEUROLOGY

Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: A phase III randomized, double-blind, placebo-controlled trial

(2013) Victor Biton et al.   EPILEPSIA

Adjunctive brivaracetam for uncontrolled focal and generalized epilepsies: Results of a phase III, double-blind, randomized, placebo-controlled, flexible-dose trial

(2013) Patrick Kwan et al.   EPILEPSIA

Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: Results from a double-blind, randomized, placebo-controlled trial

(2013) Philippe Ryvlin et al.   EPILEPSIA

Efficacy and safety of lacosamide in infants and young children with refractory focal epilepsy

(2013) Salvatore Grosso et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Modeling Transformations of Neurodevelopmental Sequences across Mammalian Species

(2013) A. D. Workman et al.   JOURNAL OF NEUROSCIENCE

Focal epileptiform activity in the prefrontal cortex is associated with long-term attention and sociability deficits

(2013) Amanda E. Hernan et al.   NEUROBIOLOGY OF DISEASE

Lacosamide in pediatric and adult patients: Comparison of efficacy and safety

(2013) Alberto Verrotti et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Excitatory actions of GABA in the intact neonatal rodent hippocampus in vitro

(2013) Guzel Valeeva et al.   Frontiers in Cellular Neuroscience

Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers

(2012) Teresa Nunes et al.   EPILEPSIA

Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: Results of randomized global phase III study 305

(2012) Jacqueline A. French et al.   EPILEPSIA

Perampanel, a selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, as adjunctive therapy for refractory partial-onset seizures: Interim results from phase III, extension study 307

(2012) Gregory L. Krauss et al.   EPILEPSIA

Efficacy and tolerability of adjunctive brivaracetam in adults with uncontrolled partial-onset seizures: A phase IIb, randomized, controlled trial

(2012) Wim Van Paesschen et al.   EPILEPSIA

Pharmacokinetics and drug interactions of eslicarbazepine acetate

(2012) Meir Bialer et al.   EPILEPSIA

Pharmacotherapy of the third-generation AEDs: lacosamide, retigabine and eslicarbazepine acetate

(2012) Philip N Patsalos et al.   EXPERT OPINION ON PHARMACOTHERAPY

Lacosamide in Refractory Mixed Pediatric Epilepsy: A Prospective Add-on Study

(2012) Reena Gogia Rastogi et al.   JOURNAL OF CHILD NEUROLOGY

Efficacy of antiepileptic drugs in adults predicts efficacy in children: A systematic review

(2012) J. M. Pellock et al.   NEUROLOGY

Adjunctive perampanel for refractory partial-onset seizures: Randomized phase III study 304

(2012) J. A. French et al.   NEUROLOGY

In search of epilepsy biomarkers in the immature brain: goals, challenges and strategies

(2011) Aristea S Galanopoulou et al.   Biomarkers in Medicine

Perampanel: A novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy

(2011) Takahisa Hanada et al.   EPILEPSIA

Efficacy and tolerability of oral lacosamide as adjunctive therapy in pediatric patients with pharmacoresistant focal epilepsy

(2011) M. Gavatha et al.   EPILEPSY & BEHAVIOR

Incidence and classification of new-onset epilepsy and epilepsy syndromes in children in Olmsted County, Minnesota from 1980 to 2004: A population-based study

(2011) Elaine C. Wirrell et al.   EPILEPSY RESEARCH

Preliminary efficacy and safety of lacosamide in children with refractory epilepsy

(2011) Eli Heyman et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: Relationship to anti-convulsant properties

(2011) Michel Gillard et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Linking Topography to Tonotopy in the Mouse Auditory Thalamocortical Circuit

(2011) T. A. Hackett et al.   JOURNAL OF NEUROSCIENCE

A critical period for auditory thalamocortical connectivity

(2011) Tania Rinaldi Barkat et al.   NATURE NEUROSCIENCE

Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine

(2011) Andreas Meyer-Lindenberg et al.   NATURE REVIEWS NEUROSCIENCE

Experience With Lacosamide in a Series of Children With Drug-Resistant Focal Epilepsy

(2011) Laura M.F.F. Guilhoto et al.   PEDIATRIC NEUROLOGY

Extrapolation of Adult Data and Other Data in Pediatric Drug-Development Programs

(2011) J. Dunne et al.   PEDIATRICS

Lacosamide as adjunctive therapy for partial-onset seizures: A randomized controlled trial

(2010) Steve Chung et al.   EPILEPSIA

Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy

(2010) E. Ben-Menachem et al.   EPILEPSY RESEARCH

Quantitative analysis of postnatal neurogenesis and neuron number in the macaque monkey dentate gyrus

(2010) Adeline Jabès et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Adjunctive brivaracetam for refractory partial-onset seizures: A randomized, controlled trial

(2010) J. A. French et al.   NEUROLOGY

Off-Label Prescribing to Children in the United States Outpatient Setting

(2009) Alicia T.F. Bazzano et al.   Academic Pediatrics

Efficacy and safety of 800 and 1200 mg eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures

(2009) A. Gil-Nagel et al.   ACTA NEUROLOGICA SCANDINAVICA

Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial

(2009) Péter Halász et al.   EPILEPSIA

The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after multiple increasing oral doses in healthy men

(2008) Paul Rolan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetics, Efficacy, and Tolerability of Eslicarbazepine Acetate in Children and Adolescents With Epilepsy

(2008) Luis Almeida et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Excitatory GABA in Rodent Developing Neocortex In Vitro

(2008) Sylvain Rheims et al.   JOURNAL OF NEUROPHYSIOLOGY

Outcomes of epilepsy surgery in adults and children

(2008) Susan Spencer et al.   LANCET NEUROLOGY