Article
Biochemistry & Molecular Biology
Annarita Stringaro, Stefano Serra, Alessandro Gori, Annarica Calcabrini, Marisa Colone, Maria Luisa Dupuis, Francesca Spadaro, Serena Cecchetti, Alberto Vitali
Summary: This study analyzed the cell specificity, cell viability effects, intracellular distribution, and immune cell response of a new peptide conjugate of Aloe-emodin in SKBR3 and A549 cell lines. The results showed that the conjugate was more effective at reducing cell viability than AE in both cell lines, with a nuclear localization in SKBR3 cells and cytoplasmic distribution in A459 cells.
Article
Biochemistry & Molecular Biology
Martyna Nowak-Perlak, Mariusz A. Bromke, Piotr Ziolkowski, Marta Wozniak
Summary: This study investigated the potential of emodin and aloe-emodin as photosensitizers in photodynamic therapy for skin cancer. The results showed that these two substances can affect skin cancer cells and normal skin cells in different ways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Guorong Cheng, Zhiqiang Liu, Zhong Zheng, Fengrui Song, Xiaoyu Zhuang, Shu Liu
Summary: Through cell metabolomics, this study found that aloe emodin and emodin can inhibit the metastasis of breast cancer cells by inhibiting adhesion, invasion, angiogenesis, and inducing anoikis. Metabolomics analysis also revealed the involvement of multiple pathways, including polyamine metabolism, methionine cycle, TCA cycle, glutathione metabolism, purine metabolism, and aspartate synthesis. The inhibitory effect of aloe emodin was significantly better than emodin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xueqing Tang, Yue Zhang, Xin Liu, Xiaohan Li, Hongrui Zhao, Hao Cui, Yang Shi, Yongchao Chen, Honglin Xu, Ziyu Meng, Limin Zhao, Hui Chen, Zhixia Wang, Mengying Zhu, Yuan Lin, Baofeng Yang, Yong Zhang
Summary: Atherosclerosis is a highly lethal inflammatory disease associated with endothelial dysfunction. A study found that aloe-emodin derivative (AED) can reduce the development and progression of atherosclerosis by enhancing endothelial cell autophagy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Lupeng Zeng, Huaying Wang, Wanhua Shi, Lingfan Chen, Tingting Chen, Guanyu Chen, Wenshen Wang, Jianming Lan, Zhihong Huang, Jing Zhang, Jinghua Chen
Summary: This study proposed a nanocarrier made from aloe with stability and leak-proofness, showing no toxicity to melanoma cells, and demonstrating good efficacy both in vitro and in vivo. The nanocarrier showed great stability and effectiveness in delivering Indocyanine green, with potential applications in noninvasive transdermal administration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Hyeon Jeong Kim, Ji Won Choi, Jin Ree, Jung Sik Lim, Jisun Lee, Jun Il Kim, Samir Bahadur Thapa, Jae Kyung Sohng, Yong Il Park
Summary: This study demonstrated that AE3G significantly and more effectively inhibited the growth and migration of human NSCLC cells than AE by triggering mitochondria-dependent intrinsic apoptosis, suggesting AE3G as a potential new drug candidate for preventing or treating human NSCLC.
Article
Food Science & Technology
Jingqi Zhao, Yantong Sun, Li Ren, Shuqing Huang, Jie Zhang
Summary: Aloe-emodin, a novel androgen receptor (AR) antagonist, has been identified to inhibit AR signaling by promoting apoptosis, modulating AR protein levels, inhibiting AR downstream target genes, and preventing the nuclear translocation of AR. These findings suggest that aloe-emodin may play a crucial role in prostate cancer prevention and treatment.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Zhao Deng, Hang Sun, Rammohan R. Yadav Bheemanaboina, Yan Luo, Cheng-He Zhou
Summary: Due to the significant increase in drug resistance, researchers have developed a novel type of aloe emodin-hybridized sulfonamide aminophosphates as potential antibacterial agents. These hybrids have shown strong inhibitory activity against drug-resistant E. faecalis, as well as low hemolysis and efficient biofilm-disruptive ability. Furthermore, they possess the ability to permeate and depolarize bacterial membranes, promote ROS accumulation, and intercalate with DNA. Therefore, further development of these hybrids is warranted to combat life-threatening bacterial infections.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Oncology
Dongxiao Jiang, Shufei Ding, Zhujun Mao, Liyan You, Yeping Ruan
Summary: The research findings suggest that aloe-emodin may induce apoptosis of human colon cancer cells through mitochondria-related pathways.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Hai Shang, Yue Hu, Jingrong Li, Lingyu Li, Yu Tian, Xiaoxue Li, Qi Wu, Zhongmei Zou
Summary: A series of novel aloe-emodin-coumarin hybrids were designed and synthesized, and their antitumor activity was evaluated. Some of the synthesized compounds showed moderate to good activity against multiple tumor cell lines, especially compound 5d, which exhibited stronger antiproliferative activity than the reference drug etoposide. Furthermore, a structure-activity relationship study of the synthesized compounds was performed.
Article
Chemistry, Physical
Rezvan Gholami, Mohammad Solimannejad
Summary: This research investigates the adsorption and release of aloe-emodin anticancer drug on the B24N24 nanocage. The results indicate that the B24N24 nanocage could be a potential carrier for delivering aloe-emodin drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Oncology
Minghui Peng, Zhuifeng Zheng, Shaoyang Chen, Le Fang, Rongxiu Feng, Lijun Zhang, Qingnan Tang, Xuewen Liu
Summary: This study found that AE can enhance the sensitivity of PC9-GR cells to gefitinib and reverse EMT. AE achieves these effects by blocking the PI3K/Akt/TWIS1 signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yun Xie, Jiao Li, Chengcheng Liu, Xiaofei Zhang, Xinran Zhang, Qi Wang, Lixia Zhang, Shaoqing Yang
Summary: This study evaluated the efficacy of aloeemodin (AE), a photosensitizer extracted from traditional Chinese herbs, in antimicrobial photodynamic therapy (aPDT) against antibiotic-sensitive and antibiotic-resistant Pseudomonas aeruginosa. The results showed that AE-mediated aPDT effectively inactivated both types of bacteria by damaging their cytoplasm and cell membrane. This suggests the potential use of AE in treating multidrug-resistant Pseudomonas aeruginosa infections.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Jingqian Su, Siyuan Chen, Jianbin Xiao, Zhihua Feng, Shan Hu, Qiaofen Su, Qi Chen, Duo Chen
Summary: This study explores the therapeutic potential of aloe-emodin (AE) in the treatment of CLP-induced sepsis, demonstrating its ability to mitigate systemic inflammation and regulate the gut microbiota. The study provides novel insights into the molecular mechanisms underlying the anti-inflammatory effects of AE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Mingyang Zhu, Qingmin He, Yanan Wang, Liying Duan, Kang Rong, Yingying Wu, Ye Ding, Yang Mi, Xiaoyang Ge, Xiaocui Yang, Yong Yu
Summary: This study investigated the molecular mechanism of aloe-emodin (AE) in the treatment of hepatocellular carcinoma (HCC) using network pharmacology and molecular docking. The results showed that AE exerted a therapeutic effect on HCC by modulating multiple signaling pathways, particularly the PI3K-AKT signaling pathway. Various analyses confirmed the antiproliferative activity and pro-apoptotic effect of AE on HCC. This study revealed the therapeutic mechanism of AE in the treatment of HCC through a novel approach, providing a theoretical basis for its clinical application.
FRONTIERS IN PHARMACOLOGY
(2023)