Article
Biochemistry & Molecular Biology
Maria Giovanna Lupo, Silvia Marchiano, Maria Pia Adorni, Francesca Zimetti, Massimiliano Ruscica, Maria Francesca Greco, Alberto Corsini, Nicola Ferri
Summary: Overexpression of PCSK9 in rat SMCs led to downregulation of LDL receptor and marker of contractile phenotype. This resulted in increased cell proliferation rate and partial resistance to simvastatin, indicating a potential role of PCSK9 in atherosclerotic plaque development and pharmacological response to statins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Kush K. K. Patel, Khosrow Kashfi
Summary: Cholesterol is a vital molecule for maintaining normal physiological homeostasis and serves as a precursor for various substances. However, high cholesterol levels are associated with diseases and cancer progression. Mechanisms for cholesterol-mediated cancer progression include activation of oncogenic signaling pathways and induction of oxidative stress. Lipoprotein molecules HDL and LDL play important roles in this pathogenesis. Some cholesterol-lowering medications may have potential in cancer treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anna Pierzchlinska, Marek Drozdzik, Monika Bialecka
Summary: Parkinson's disease is a neurodegenerative disorder with unclear etiology and treatment options. Studies suggest that statins may have neuroprotective effects, but the data on this are conflicting. Cholesterol is essential for brain function and may also play a role in protecting against Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Sandip Rahangdale, Rajshree Fating, Mona Gajbhiye, Mona Kapse, Nazma Inamdar, Nandkishor Kotagale, Milind Umekar, Brijesh Taksande
Summary: Statins have antidepressant-like effects, potentially through promoting the release of agmatine and interacting with imidazoline receptors. These drugs also increase the levels of agmatine in the brain, presenting a new direction for potential treatment of depression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Oliver J. Liakopoulos, Elmar W. Kuhn, Martin Hellmich, Markus Schloemicher, Justus Strauch, Wilko Reents, Anno Diegeler, Matthias Thielmann, Daniel Wendt, Jochen Boergermann, Jan F. Gummert, Christian Stoppe, Andreas Goetzenich, Sven Martens, Hermann Reichenspurner, Jens Wippermann, Hannes Reuter, Yeong-Hoon Choi, Thorsten Wahlers
Summary: This study aimed to analyze the effects of high-dose statin therapy before surgical revascularization. The results showed that additional statin loading before surgery did not reduce the rate of major adverse cardiac and cerebrovascular events (MACCE) occurring within 30 days.
EUROPEAN HEART JOURNAL
(2023)
Article
Cell Biology
Prema S. Rao, U. Subrahmanyeswara Rao
Summary: Statins inhibit cancer cell proliferation by suppressing the mevalonate/cholesterol biosynthesis pathway, leading to cell cycle arrest at G0/G1 phase, reduction of c-Myc protein expression, and induction of cellular senescence.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Jonas Ghouse, Gustav Ahlberg, Anne Guldhammer Skov, Henning Bundgaard, Morten S. Olesen
Summary: Inhibition of the HMGCR gene was found to be associated with an increased risk of cataract, suggesting that long-term statin treatment may lead to cataract formation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Nicholas B. Alana, William A. Ciurylo, Natalie Hurlock
Summary: This study suggests that moderate and high intensity statin medications may reduce the frequency of DIC in critically ill patients with severe sepsis or septic shock.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Review
Peripheral Vascular Disease
Mitra Nekouei Shahraki, Soroush Mohammadi Jouabadi, Daniel Bos, Bruno H. Stricker, Fariba Ahmadizar
Summary: This review aimed to determine the association between statin use and coronary artery calcification (CAC) in the general population. The analysis of previously published observational studies and randomized controlled trials revealed differences in the effects of statins on CAC depending on the study design.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Review
Peripheral Vascular Disease
Mitra Nekouei Shahraki, Soroush Mohammadi Jouabadi, Daniel Bos, Bruno H. Stricker, Fariba Ahmadizar
Summary: This review aimed to determine the association between statin use and coronary artery calcification (CAC). Observational studies found an association between statin use and higher CAC scores and presence, while randomized controlled trials did not show statistically significant results and varied depending on the quantification method.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Review
Pharmacology & Pharmacy
David M. Dolivo, Charlotte R. Reed, Kristine A. Gargiulo, Adrian E. Rodrigues, Robert D. Galiano, Thomas A. Mustoe, Seok Jong Hong
Summary: Fibrosis is a common pathological repair process in organs, but there is a lack of effective therapeutic methods. Repurposing existing drugs, such as statins, can be a complementary strategy to treat tissue fibrosis. Statins have been found to have anti-fibrotic effects through various mechanisms, and a better understanding of these effects can aid in the development of novel therapeutic agents.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ayala Hirsch, Natali Ternovsky, Donna R. R. Zwas, Reut Rotem, Offer Amir, Bruria Hirsh Raccah
Summary: This study assessed the effect of statin exposure during pregnancy on congenital anomalies and spontaneous abortions. The results showed that overall, treatment with statins during pregnancy was not associated with an increased risk of congenital anomalies. There was also no significant association between lipophilic statins and the rate of congenital anomalies. However, pregnant women receiving statins did have a slight elevation in the risks of cardiac malformation and spontaneous abortions.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Environmental Sciences
Sukhbir Singh, Ishrat Zahoor, Neelam Sharma, Tapan Behl, Neha Kanojia, Aayush Sehgal, Syam Mohan, Yosif Almoshari, Ahmad Salawi, Lotfi Aleya, Simona Bungau
Summary: Hyperlipidemia, characterized by high levels of lipids and lipoproteins in blood circulation, is the primary cause of heart disorders. Pharmacologic therapy and lifestyle adjustments can be used for both primary and secondary prophylaxis of heart disease. Statins, particularly HMG-CoA reductase inhibitors, are preferred for primary prevention. Recent advancements in nanoparticle drug carriers for statins in hyperlipidemia therapy are discussed in this review.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Neurosciences
Yahui Zhu, Mao Li, Hongfen Wang, Fei Yang, Jiao Wang, Xusheng Huang
Summary: This Mendelian randomization (MR) study aimed to assess the association between genetically proxied cholesterol and the age at onset of Huntington's disease (HD). The results showed that plasma cholesterol levels and HMG-CoA reductase inhibition were not associated with the age at onset of HD.
Review
Cardiac & Cardiovascular Systems
Dongbo Yu, James K. Liao
Summary: This review discusses the development of statins, their non-lipid-lowering benefits, and proposes future research directions in this field.
CARDIOVASCULAR RESEARCH
(2022)
