Article
Biology
Hung Wei Lai, Moe Kasai, Shinkuro Yamamoto, Hideo Fukuhara, Takashi Karashima, Atsuhi Kurabayashi, Mutsuo Furihata, Kazuhiro Hanazaki, Keiji Inoue, Shun-ichiro Ogura
Summary: This study aimed to investigate the relationship between cell density and cancer stem cells (CSCs) in prostate cancer and the role of the Warburg effect in regulating CSC-like characteristics. The researchers used the PC3 prostate cancer cell line to measure the expression levels of glycolysis and OXPHOS-related genes and performed various assays to assess CSC-like characteristics. They found that increased cell density caused a metabolic shift from glycolysis to OXPHOS and increased CSC-like characteristics. However, inhibition of the Warburg effect with dichloroacetate (DCA) significantly prevented this metabolic shift and CSC-like characteristics induced by cell density. This suggests that DCA could be a promising drug for targeting CSCs and preventing cancer relapses.
Article
Oncology
Indrani Dutta, Dylan Dieters-Castator, James W. Papatzimas, Anais Medina, Julia Schueler, Darren J. Derksen, Gilles Lajoie, Lynne-Marie Postovit, Gabrielle M. Siegers
Summary: Gamma delta T cells (γδ Tc) show promising potential in targeting breast cancer stem-like cells (BCSC), although some BCSC may escape from the immunotherapy. The resistance of BCSC can be partially overcome by regulating MCL-1 and PD-L1, and blocking MICA shedding can increase the sensitivity of BCSC to gamma delta Tc.
Article
Biochemistry & Molecular Biology
Juan Carlos Gallardo-Perez, Alheli Adan-Ladron de Guevara, Marco Antonio Garcia-Amezcua, Diana Xochiquetzal Robledo-Cadena, Silvia Cecilia Pacheco-Velazquez, Javier Alejandro Belmont-Diaz, Jorge Luis Vargas-Navarro, Rafael Moreno-Sanchez, Sara Rodriguez-Enriquez
Summary: This study found that oxidative phosphorylation is the main supplier of ATP in breast cancer stem cells (BCSC). By using drugs that inhibit oxidative phosphorylation, the viability and metastatic properties of BCSC can be significantly reduced.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Pegah Farhadi, Shiva Irani, Mohammadreza Gholami, Kamran Mansouri
Summary: Tumor metabolism is a promising target for cancer therapy, as the metabolic pathways of cancer cells differ from normal cells. In this study, three inhibitors were used to target glycolysis, pentose phosphate pathway, and mitochondria in breast cancer cells. The combination of these drugs showed the most effective inhibitory action, suggesting their potential as an efficient anti-cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Rodrigo A. Acuna, Manuel Varas-Godoy, Diego Herrera-Sepulveda, Mauricio A. Retamal
Summary: Connexins are a family of proteins that play a crucial role in cellular communication, but certain types may have pro-tumorigenic effects. Research has shown that Cx46 can modulate the characteristics of cancer stem cells and epithelial-to-mesenchymal transition in breast cancer cells, potentially influencing future cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Sara Bartlome, Catherine Cecilia Berry
Summary: This article introduces the metabolic characteristics of dormant breast cancer cells and their relationship with different subtypes and receptor statuses. By further studying these differences, new personalized therapeutic possibilities can be provided for breast cancer patients.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Giang Le Minh, Emily M. Esquea, Tejsi T. Dhameliya, Jessica Merzy, Mi-Hye Lee, Lauren E. Ball, Mauricio J. Reginato
Summary: Breast tumor development is regulated by cancer stem-like cells (CSC) which are capable of self-renewal and differentiation. O-GlcNAc transferase (OGT) and O-GlcNAcylation are enriched in CSC populations and promote stemness and tumorigenesis of breast cancer cells. Upregulation of KLF8 is associated with OGT enrichment and plays a potential role in regulating CSC properties.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Huan He, Shaozheng Wang, Wen Zhang, Shanshan Gao, Hua Guan, Pingkun Zhou
Summary: TAB182 plays a role in DNA damage repair and radio-/chemosensitivity regulation in various tumors, but its role in breast cancer, especially triple-negative breast cancer (TNBC), was unclear. This study found that TAB182 expression is lower in TNBC and its knockdown promotes tumor cell proliferation, migration, and invasion. The downregulation of TAB182 leads to enhanced cancer stem-like cell properties and resistance to certain drugs. These findings suggest that TAB182 may serve as a tumor suppressor gene and has potential therapeutic implications for TNBC patients.
Article
Pharmacology & Pharmacy
Yen Thi-Kim Nguyen, Ngoc Bao To, Vi Nguyen-Phuong Truong, Hee Young Kim, Meran Keshawa Ediriweera, Yoongho Lim, Somi Kim Cho
Summary: Targeting cancer stem cell metabolism has emerged as a promising therapeutic strategy for cancer treatment. This study explored the glucose metabolism machinery of breast cancer stem cells (BCSCs) and the regulation of glucose metabolism and stemness characteristics by nootkatone. The results showed that BCSCs primarily rely on glycolysis for energy supply and nootkatone impairs glucose metabolism and reduces stemness characteristics through AMPK activation.
Article
Cell & Tissue Engineering
Sidse Ehnnsen, Henrik J. Ditzel
Summary: Breast cancer stem cells play a crucial role in cancer initiation, therapy resistance, and progression, with recent research focusing on cellular signaling pathways such as the WNT pathway, NF-κB pathway, and cholesterol biosynthesis pathway. Targeting these pathways in combination with standard treatments may improve the prognosis of breast cancer patients.
Article
Oncology
Li Ding, Wang Kun, Wenjing Xu, Shaohua Chen, Zhaogen Cai
Summary: This study compared the clinicopathological and immunohistochemical characteristics of centrally necrotizing carcinoma of the breast (CNC) and basal-like breast cancer (BLBC), and analyzed the molecular typing of CNC. The results showed that the proportion of basal cell type in CNC was significantly higher than that of other types. There were no significant differences in the expression of BRCA1 and VEGF protein between BLBC and CNC, but there was a significant difference in HIF-1a protein expression. The study suggests that targeted therapy for BRCA1 in BLBC may also be effective in CNC patients.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Rilan Bai, Ying Meng, Jiuwei Cui
Summary: Metabolic reprogramming is a crucial process in cancer, contributing to malignant proliferation, tumor development, and treatment resistance. Various therapeutic drugs targeting metabolic reactions, transport receptors, and specific metabolic processes have been developed. This review explores the characteristics of metabolic changes in cancer cells, such as alterations in glycolytic pathways, lipid metabolism, and glutamine metabolism, and discusses how these changes promote tumor development and resistance. The progress and challenges of therapeutic strategies targeting different aspects of tumor metabolism, based on current research, are summarized.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Alicja Urbaniak, Megan R. Reed, Daniel Fil, Anika Moorjani, Sarah Heflin, Michal Antoszczak, Michal Sulik, Adam Huczynski, Michalina Kupsik, Robert L. Eoff, Melanie C. MacNicol, Timothy C. Chambers, Angus M. MacNicol
Summary: This study suggests that compound 17 has improved activity against breast cancer stem cells compared to Salinomycin, showing potential for further development in clinical applications targeting CSCs.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Anthony Nguyen, Anna H. Kim, Mo K. Kang, No-Hee Park, Reuben H. Kim, Yong Kim, Ki-Hyuk Shin
Summary: Chronic alcohol exposure promotes cancer stemness and aerobic glycolysis through activation of NFAT signaling. This study provides new insights into the roles of cancer stemness and metabolic reprogramming in the mechanism of alcohol-mediated carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yawei Zhao, Xuehan Yang, Jingtong Zhao, Mohan Gao, Min Zhang, Tongfei Shi, Fan Zhang, Xiao Zheng, Yue Pan, Dan Shao, Jing Li, Kan He, Li Chen
Summary: The study revealed the crucial role of berberine in overcoming chemotherapy-exacerbated ovarian cancer metastasis, by inhibiting the GLI1/BMI1 signaling pathway to reverse EMT and migration, as well as reduce CSC-like characteristics.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)