Review
Surgery
Haodong Xiao, Wei Kou, Yuan Yang, Erkuan Dai, Xuerui Zhang, Yanjun Wen, Jie Peng, Ping Fei, Peiquan Zhao
Summary: This study reviewed cases of vision loss related to filler injections and discussed the potential efficacy of hyaluronidase treatment using different administration methods. The results showed that subcutaneous and intra-arterial administration of hyaluronidase helped with visual recovery to varying extents.
AESTHETIC PLASTIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Sandip P. Patil, Leena P. Shirsath, Bhushan L. Chaudhari
Summary: A halotolerant bacterium isolated from dental caries was found to produce the enzyme hyaluronidase, which showed high activity and stability at pH 7.0 and 40 degrees C, as well as in 2M NaCl solution. The enzyme exhibited wide substrate specificity with hyaluronic acid as the best substrate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Aditya Kaul, Walker D. Short, Xinyi Wang, Sundeep G. Keswani
Summary: This article discusses the important role of hyaluronidases in human tissues, especially in promoting disease progression, and the potential benefits as clinical treatments currently and in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Yun Jeong Lee, Se Joon Woo
Summary: This study analyzed the long-term visual outcomes and complications of facial filler-related ophthalmic and retinal artery occlusion, finding that most patients experienced irreversible visual impairment despite various treatments. Various long-term ocular and extraocular complications were observed, emphasizing the importance of prevention over treatment.
AESTHETIC SURGERY JOURNAL
(2022)
Review
Engineering, Biomedical
Fernanda Zamboni, Chun Kwok Wong, Maurice N. Collins
Summary: This article discusses the interaction between hyaluronic acid and pathogenic microorganisms, as well as the antimicrobial activity of different molecular weights of hyaluronic acid in biomedical and pharmaceutical applications. These studies are crucial for the development of next generation antimicrobial therapeutic strategies.
BIOACTIVE MATERIALS
(2023)
Article
Surgery
Christine Ryu, Jonathan E. Lu, Sandy Zhang-Nunes
Summary: This study evaluated the in vitro responses of 12 HA fillers to varying doses of recombinant human hyaluronidase (RHH). Results showed different levels of resistance of different fillers to hyaluronidase.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Chemistry, Physical
Pushap Raj, Seon-yeong Lee, Tae Yoon Lee
Summary: Bladder cancer is the leading cause of death in patients with genitourinary cancer. Elevated levels of hyaluronidase (HAase) can serve as an important biomarker for early diagnosis. A simple, sensitive, and ratiometric fluorescence assay for HAase detection has been developed, with a detection limit below normal human body fluid levels. The assay may be useful for diagnosing HAase-related diseases.
Article
Surgery
Jianfeng Wang, Haiyang Shen, Tao Liu, Qian Li, Zhaoyang Lyu, Youtao Yu
Summary: The study evaluated the efficacy and safety of recanalizing hyaluronic acid-occluded retinal central artery by intra-arterially infusing hyaluronidase in patients with monocular blindness. The results indicated that this approach was effective and safe for recovering visual acuity in such patients.
AESTHETIC PLASTIC SURGERY
(2021)
Review
Oncology
Kevin Domanegg, Jonathan P. Sleeman, Anja Schmaus
Summary: CEMIP is a protein that has been implicated in the pathogenesis of various diseases, particularly colorectal cancer. It plays a role in tumor growth and metastasis, and its expression is associated with poor prognosis. CEMIP contributes to tumor progression and metastasis through multiple mechanisms.
Article
Surgery
Leonie W. Schelke, Peter J. Velthuis, Tom Decates, Jonathan Kadouch, Michael Alfertshofer, Konstantin Frank, Sebastian Cotofana
Summary: This study compared the ultrasound-guided targeted and flooding protocols for managing adverse vascular events following hyaluronic acid-based aesthetic injections. The results showed that the ultrasound-guided targeted protocol utilized less hyaluronidase and restored clinical symptoms faster.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Dermatology
Marina Aguilar-Gonzalez, Juan Davo-Cabrera, Nuria Rausell-Fontestad, Rafael Botella-Estrada, Enrique Espana-Gregori, Marta Perez-Lopez
Summary: The application of hyaluronidase in periocular skin leads to the presence of deposits, but does not alter the structure of elastin and collagen dermis.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Materials Science, Multidisciplinary
Mujahid Iqbal, Aqeela Yasin, Ambreen Akram, Jing-An Li, Kun Zhang
Summary: Hyaluronic acid (HA) is a versatile material that can be modified to enhance its stability. Sulfated hyaluronic acid (S-HA) can be synthesized and has slower degradation by hyaluronidase compared with HA. S-HA has numerous applications in medical and cosmetic fields as biomaterials and coatings.
Article
Biophysics
Martin Sindelar, Jana Jilkova, Lukas Kubala, Vladimir Velebny, Kristyna Turkova
Summary: Hyaluronan is a crucial component in the human body with various applications in biological processes and medical fields. Hyaluronidases and hyaluronate lyases play significant roles in hyaluronan degradation, showing diversity in structure and function properties.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Dermatology
Adriana Rodriguez-Valera, Francisco Nieto-Lopez
Summary: Aesthetic medicine emphasizes the importance of treatment efficiency and safety. However, adverse events such as vascular occlusion may occur. In this study, we propose the use of hyperbaric oxygenation treatment as an adjunct therapy to promote tissue oxygenation and regeneration after vascular occlusion caused by tissue fillers. The results show that hyperbaric oxygenation treatment is effective in improving tissue regeneration and preventing scarring or sequelae.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Raffaele Rauso, Nicola Zerbinati, Romolo Fragola, Giovanni Francesco Nicoletti, Gianpaolo Tartaro
Summary: HYAL has the capability to degrade crosslinked HA injected into human vessels, relieving vascular obstruction. In case of embolism, multiple high doses of HYAL may be required to restore blood flow.
DERMATOLOGIC SURGERY
(2021)
Article
Dermatology
Antonello Tateo, Gabriel Siquier-Dameto, Ofir Artzi, Dalvi Humzah, Beatriz Molina, Ravi Jain, Arturo Lanzarotti, Malika Laouedj, Nicolas Dapis, Gilberto Bellia
Summary: The study described the development and validation of the IBSA Neck Laxity Scale, which showed high reliability for assessing neck laxity. This validated scale provides an effective method for evaluating neck laxity.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)