Article
Microbiology
Andras Kallai, Marta Kelemen, Noemi Molnar, Adrienn Tropotei, Balazs Hauser, Zsolt Ivanyi, Janos Gal, Erzsebet Ligeti, Katalin Kristof, Akos M. Lorincz
Summary: The study developed a flow cytometry-based antibiotic susceptibility testing (AST) method, which can produce reliable results a workday earlier than the traditional microdilution method. Results showed that the method is able to detect bacterial growth accurately after 4 hours of incubation, with high consistency compared to the microdilution method.
MICROBIOLOGY SPECTRUM
(2021)
Article
Obstetrics & Gynecology
Yuval Fouks, Eran Ashwal, Yariv Yogev, Sharon Amit, Tali Ben Mayor Bashi, Noa Sinai, Anastasia Firsow, Eyal Hasson, Ronni Gamzu, Ariel Many
Summary: Administration of cefazolin to pregnant women before Cesarean delivery can prevent surgical-related infection. One or two grams of cefazolin before the incision can provide adequate serum concentrations.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Veterinary Sciences
Anno de Jong, Myriam Youala, Ulrich Klein, Farid El Garch, Shabbir Simjee, Hilde Moyaert, Markus Rose, Anne V. Gautier-Bouchardon, Salvatore Catania, Kannan Ganapathy, Miklos Gyuranecz, Franca Moller Palau-Ribes, Andrew Pridmore, Roger D. Ayling
Summary: This study presents the results of the first international antimicrobial susceptibility programme for mycoplasma pathogens isolated from poultry, providing a baseline of novel data for future monitoring of antimicrobial resistance in poultry Mycoplasma species. The study indicates variations in susceptibilities based on host species, Mycoplasma species, and country of origin, and highlights the importance of selecting effective antimicrobial agents for targeted therapeutic treatments.
Article
Biochemical Research Methods
Corrie R. Belanger, Robert E. W. Hancock
Summary: This study presents a protocol for testing physiologically relevant infection conditions in minimal inhibitory concentration (MIC) assays, which can be used to assess the susceptibility of bacterial isolates and novel antimicrobial drugs under conditions more similar to clinical infections. The protocol can be applied to most physiologically relevant liquid medium and aerobic pathogens, taking 3-4 days to complete, and may provide a more accurate assessment of the bactericidal effects of new drugs.
Review
Surgery
Matthew Coates, Alison Shield, Gregory M. Peterson, Zahid Hussain
Summary: There is currently no consensus on whether an increased cefazolin dose is necessary for obese surgical patients. A systematic review of outcome and pharmacokinetic studies found that a 2-g dose of cefazolin is sufficient for surgery lasting up to 4 hours, but large-scale outcome studies are needed to confirm this conclusion.
Article
Microbiology
Suman Tiwari, Oliver Nizet, Nicholas Dillon
Summary: The history of MIC determination dates back to the early 1900s, and efforts have been made to improve its reliability and accuracy. Current MIC testing procedures are not efficient in evaluating a large number of samples, but our high-throughput MIC workflow using Opentrons OT-2 robot and Python programming is faster, more efficient, and more accurate.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Anesthesiology
Yamini Subramani, Mahesh Nagappa, Kamal Kumar, Rokhsana Mortuza, Lee-Anne Fochesato, Moaz Bin Yunus Chohan, Janet Martin, Kevin Armstrong, Sudha (Indu) Singh
Summary: This systematic review and network meta-analysis evaluated the effectiveness of medications used for preventing intrathecal morphine-induced pruritus after cesarean delivery. The results showed serotonin-receptor antagonists and opioid agonist-antagonists may decrease pruritus incidence compared to control group, but the quality of the overall analysis was low. Further RCTs with clearly defined endpoints are needed to confirm these findings.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Infectious Diseases
Qin Tang, Hui Ke, Wen-wen Sun, Shao-jun Zhang, Lin Fan
Summary: This study aims to correlate the Minimum Inhibitory Concentration (MIC) value of drugs with the outcome of patients with MDR/RR-TB to obtain an understanding for better regimens and optimal outcomes.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Nutrition & Dietetics
Zijun Liao, Jing Wang, Fangfang Chen, Yiren Chen, Ting Zhang, Gongshu Liu, Xianghui Xie, Jun Tai
Summary: This study found that cesarean delivery may increase the risk of overweight and obesity in preschool children, and also lead to an increase in their fat mass, while fat-free mass does not significantly change.
Review
Microbiology
Beata Kowalska-Krochmal, Ruth Dudek-Wicher
Summary: The inefficiency of medical therapies for curing patients with bacterial infections calls for active search for new therapeutic strategies and careful selection of antibiotics based on various parameters including microbiological considerations. Proper assessment of Minimal Inhibitory Concentration (MIC) is crucial for optimizing treatment strategies and ensuring the effectiveness of infection therapy. This paper discusses methods for MIC estimation, factors influencing MIC results, and possibilities of utilizing MIC in clinical practice with consideration of pharmacokinetic/pharmacodynamic parameters.
Article
Medicine, General & Internal
Maciej Waledziak, Anna Rozanska-Waledziak
Summary: The study results indicate that obesity and overweight do not seem to influence women's preferences for mode of delivery, opinions on shared decision making, and preferences for cesarean delivery on request without medical indications. However, for women with morbid obesity (BMI >= 35 kg/m(2)), the sample size was too small for the results to be considered significant and further studies are needed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Fisheries
Rute Irgang, Ruben Avendano-Herrera
Summary: This study analyzes the susceptibility patterns of Tenacibaculum dicentrarchi to tiamulin and suggests that tiamulin is a viable alternative to florfenicol for the treatment of tenacibaculosis in the Chilean salmon industry.
JOURNAL OF FISH DISEASES
(2022)
Article
Microbiology
Rundong Tan, Anqi Yu, Ziming Liu, Ziqi Liu, Rongfeng Jiang, Xiaoli Wang, Jialin Liu, Junhui Gao, Xinjun Wang
Summary: MIC is crucial for bacterial detection in infections, and predicting MIC accurately using genome sequencing and machine learning algorithms can improve clinical efficacy and antibiotic use.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Patchareya Nivatpumin, Tripop Lertbunnaphong, Siritorn Maneewan, Nutha Vittayaprechapon
Summary: This study compared the perioperative outcomes and anesthetic-related complications in morbidly obese and super-obese parturients undergoing cesarean section. The super-obese patients had higher intraoperative bleeding, more hypotensive episodes, and greater vasopressor requirement than the morbidly obese patients. Anesthesiologists should be prepared for adverse perioperative events in super-obese parturients.
ANNALS OF MEDICINE
(2023)
Review
Obstetrics & Gynecology
Metabel T. Markwei, Ifeoluwa Babatunde, Nityam Rathi, Cong Fan, Marie-Ann Prah, Julia Joo, Loren Hackett, David E. Soper, Oluwatosin Goje
Summary: The study shows that preincision cefazolin with adjunctive prophylaxis can significantly reduce postcesarean delivery surgical site infections and duration of hospital stay compared to cefazolin alone, but does not have a significant effect on maternal febrile morbidity. Future investigations are needed to establish the relative efficacies of different adjunctive antibiotic options.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)