Article
Neurosciences
Stephanie A. Getz, Kamran Tariq, Dylan H. Marchand, Conor R. Dickson, James R. Howe, Patrick D. Skelton, Wei Wang, Meijie Li, Jeremy M. Barry, Jennifer Hong, Bryan W. Luikart
Summary: PTEN loss leads to dendritic overgrowth in neurons, possibly due to increased microtubule polymerization rate. Inhibiting microtubule polymerization can reduce dendritic overgrowth in Pten KO neurons and improve performance in spatial memory tasks.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Haofeng Liu, Yongxin Cao, Wenjing Zhang, Zhu Liu, Yan Li, Yu Chen, Hongchang Zhang, Fei Yu, Xiayan Liu
Summary: This study identifies 78 putative IQD family genes in the genome of hexaploid wheat and characterizes one TaIQD protein. The results reveal that TaIQD proteins regulate plant cell and organ morphogenesis and provide new insights into the functions of crop IQD proteins.
Article
Neurosciences
Brikha R. Shrestha, Anita Burgos, Wesley B. Grueber
Summary: The study reveals the important role of the cell surface molecule Basigin in complex dendrite morphogenesis, with loss of the gene leading to defects in dendrite formation. Knock down of Basigin also affects dendrite elaboration of class IV neurons, suggesting a non-autonomous role in dendrite development.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Patrik Risteski, Domagoj Bozan, Mihaela Jagric, Agneza Bosilj, Nenad Pavin, Iva M. Tolic
Summary: This study discovered the importance of chromosome alignment at the spindle equator for proper chromosome segregation, which relies on the pulling forces exerted at kinetochore fiber tips and polar ejection forces. Additionally, the study found that the forces driving the poleward flux of kinetochore fibers also affect chromosome alignment. A flux-driven centering model was introduced, which depends on the flux generated by forces within the overlaps of bridging and kinetochore fibers. The study confirmed the key prediction that kinetochore fiber flux is length dependent. Several regulators of overlap and flux were identified, including Kif18A, Kif4A, and NuMA.
Article
Developmental Biology
Ravi Das, Shatabdi Bhattacharjee, Jamin M. Letcher, Jenna M. Harris, Sumit Nanda, Istvan Foldi, Erin N. Lottes, Hansley M. Bobo, Benjamin D. Grantier, Jozsef Mihaly, Giorgio A. Ascoli, Daniel N. Cox
Summary: Dendrite shape is influenced by cytoskeletal fiber organization and dynamics, impacting functional connectivity. Formin 3 is identified as a key regulator of cytoskeletal architecture in nociceptive sensory neurons, playing a crucial role in dendritic arbor complexity. Mutations in the human ortholog of Formin 3 have been linked to Charcot-Marie-Tooth disease, highlighting the importance of understanding cytoskeletal regulation in neuronal function and related neuropathies.
Article
Biochemistry & Molecular Biology
Pamela Meneses Iack, Danielle Rayee, Roberto Lent, Victor Tulio Ribeiro-Resende, Patricia P. Garcez
Summary: Cenpj is a gene that regulates axon growth and plays an important role in cortical development. This study found that silencing Cenpj in a mouse model leads to increased axonal length, more branches, larger growth cone area, and more stable microtubules. These findings suggest that Cenpj could be a novel target for axonal regeneration.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Dario Maschi, Ana J. Fernandez-Alvarez, Graciela Lidia Boccaccio
Summary: Proteins from the NANOS family play a crucial role in gonad development and also control neuron maturation and function. Knockdown of Nanos1 in hippocampal neurons impairs synaptogenesis, resulting in smaller and more numerous dendritic spines. Loss of Nanos1 also affects the contact between dendritic PSD95 clusters and pre-synaptic structures, as well as the induction of ARC triggered by neuron depolarization. These findings expand our understanding of the role of NANOS1 in CNS development and suggest its involvement in hippocampal synaptogenesis.
Article
Immunology
Bruno Jennings-Almeida, Juliana P. Castelpoggi, Erivan S. Ramos-Junior, Eliane de Oliveira Ferreira, Regina M. C. P. Domingues, Juliana Echevarria-Lima, Robson Coutinho-Silva, Aline C. A. Moreira-Souza, Eliana Marino, Charles R. Mackay, Dario S. Zamboni, Maria Bellio, Julio Scharfstein, Leandro A. Lobo, Ana Carolina Oliveira
Summary: The intestinal barrier is crucial for gut homeostasis, and a breach can lead to severe inflammatory responses, where IL-1 beta plays a significant role in peritonitis and sepsis.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Nal Ae Yoon, Sungho Jin, Jung Dae Kim, Zhong Wu Liu, Qiushi Sun, Rebecca Cardone, Richard Kibbey, Sabrina Diano
Summary: Lactate activates POMC neurons through redox signaling and blocking mitochondrial glucose utilization to regulate feeding and glucose metabolism.
Article
Cell Biology
Ang Li, Hui-Ming Zhu, Yu Chen, Fang Yan, Zhong-Ying Liu, Zhen-Lin Li, Wei-Ren Dong, Lin Zhang, Hai-Hong Wang
Summary: The study suggests that cdc42 promotes axonogenesis in rat primary hippocampal neurons by enhancing microtubule stability and promoting the dephosphorylation of CRMP-2 through increasing GSK-3 beta phosphorylation.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tsuyoshi Inoshita, Jun-Yi Liu, Daisuke Taniguchi, Ryota Ishii, Kahori Shiba-Nobutaka Hattori, Nobutaka Hattori, Yuzuru Imai
Summary: This study reveals that PD-associated genes, including LRRK2, are involved in membrane dynamics and play a role in regulating synaptic functions, axonal transport, and endolysosomal activity. The study also suggests the existence of a common pathological pathway for PD.
Article
Biology
Takeshi Otsuka, Yasuo Kawaguchi
Summary: The study shows that manipulation of specific pyramidal cell subtypes in the motor cortex has a significant impact on cortical network activity, with PT cell-dependent oscillatory activity playing an important role in motor learning.
COMMUNICATIONS BIOLOGY
(2021)
Article
Plant Sciences
Li Guan, Shurui Yang, Shenglin Li, Yu Liu, Yuqi Liu, Yi Yang, Guochen Qin, Haihai Wang, Tao Wu, Zhigang Wang, Xianzhong Feng, Yongrui Wu, Jian-Kang Zhu, Xugang Li, Lixin Li
Summary: Research has shown that AtSEC22 plays a crucial role in plant cell morphogenesis and development, with its defects leading to blocked vesicle trafficking, collapse of ER and Golgi structures, and impaired organization and stability of the cytoskeleton.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Fatima Cairrao, Cristiana C. Santos, Adrien Le Thomas, Scot Marsters, Avi Ashkenazi, Pedro M. Domingos
Summary: This study reveals that the mRNA binding protein Pumilio in fruit flies can protect Xbp1 mRNA from the non-canonical endoribonuclease activity of Ire1 by binding to it. The phosphorylation of Pumilio is crucial for its stabilization of Xbp1 mRNA.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Peipei Zhang, Masaki Ishikawa, Andrew Doyle, Takashi Nakamura, Bing He, Yoshihiko Yamada
Summary: Panx3 regulates skin development by modulating the transcription factor Epfn. Panx3(-/-) mice show impaired skin development and delayed hair follicle regeneration, while Panx3 overexpression promotes HaCaT cell differentiation.
SCIENTIFIC REPORTS
(2021)
Review
Developmental Biology
Jens Luders
Summary: The highly polarized morphology of neurons, which involves the formation of axonal and dendritic compartments, is crucial for their function. The microtubule cytoskeleton plays a key role in the morphogenesis and maintenance of axons and dendrites. Understanding the nucleation mechanisms of microtubules in neurons and their contribution to microtubule organization is essential for unraveling neuron morphogenesis.
DEVELOPMENTAL NEUROBIOLOGY
(2021)
Article
Cell Biology
Carlos Sanchez-Huertas, Marion Bonhomme, Amandine Falco, Christine Fagotto-Kaufmann, Jeffrey van Haren, Freddy Jeanneteau, Niels Galjart, Anne Debant, Jerome Boudeau
JOURNAL OF CELL BIOLOGY
(2020)
Review
Neurosciences
Oriol Busquets, Antoni Parcerisas, Ester Verdaguer, Miren Ettcheto, Antoni Camins, Carlos Beas-Zarate, Ruben Dario Castro-Torres, Carme Auladell
Summary: This review discusses the involvement of c-Jun N-terminal Kinases (JNKs) in early alterations of Alzheimer's disease (AD), including synaptic loss and dysregulation of neuronal transport. The interactions between JNKs and these processes contribute to cognitive decline in AD, with disruptions in cellular processes such as glutamatergic, GABA, and cholinergic synapses. Furthermore, the review highlights the role of the JNK-JIP complex in controlling neuronal transport and the impact of amyloid-beta aggregates and hyperphosphorylated tau on this process.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Oncology
Serena Mirra, Aleix Gavalda-Navarro, Yasmina Manso, Monica Higuera, Roman Serrat, Maria Teresa Salcedo, Ferran Burgaya, Jose Maria Balibrea, Eva Santamaria, Iker Uriarte, Carmen Berasain, Matias A. Avila, Beatriz Minguez, Eduardo Soriano, Francesc Villarroya
Summary: The protein Armcx3 is significantly increased in response to high lipid availability in the liver, and its genetic suppression protects mice against hepatocarcinogenesis induced by a high-fat diet. Armcx3 promotes hepatic cell proliferation and interacts with the known proliferation factor Sox9 in hepatocellular carcinoma. Overall, Armcx3 is identified as a novel factor in liver pathophysiology and carcinogenesis, with its downregulation showing protective effects against hepatocarcinogenesis, particularly under lipid-mediated hepatic insults.
Article
Biochemistry & Molecular Biology
Antoni Parcerisas, Alba Ortega-Gasco, Marc Hernaiz-Llorens, Maria Antonia Odena, Fausto Ulloa, Eliandre de Oliveira, Miquel Bosch, Lluis Pujadas, Eduardo Soriano
Summary: NCAM2 is a membrane protein crucial for neuronal development, interacting with over 100 proteins involved in processes such as neuronal morphogenesis and synaptogenesis. The cytosolic tail of NCAM2.1 isoform contains specific phosphorylation site motifs with affinity for key interactors like NEFs and MAP2. These findings highlight the important role of NCAM2 in cytoskeleton organization and neuronal development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Antoni Parcerisas, Alba Ortega-Gasco, Lluis Pujadas, Eduardo Soriano
Summary: NCAM2, the second member of the NCAM family, plays a crucial role in nervous system development and adulthood, especially in neuronal morphogenesis and synaptic plasticity. Its functions are related to its ability to adapt to external inputs of the cell and modify the cytoskeleton accordingly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Ricardo Viais, Marcos Farina-Mosquera, Marina Villamor-Paya, Sadanori Watanabe, Lluis Palenzuela, Cristina Lacasa, Jens Luders
Summary: The study revealed that conditional knockout of the augmin subunit in apical progenitors led to spindle defects, massive apoptosis, and failure of brain development, highlighting the crucial role of augmin in mitosis of apical progenitors and brain development progression.
Review
Neurosciences
Carlos Sanchez-Huertas, Eloisa Herrera
Summary: During the establishment of neural circuitry, axons need to cover long distances to reach remote targets. This process relies on the expression patterns of extracellular proteins and their receptors in projection neurons. Guidance proteins stimulate axon guidance and are implemented by neuronal traction forces at the growth cones.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Siamak A. Kamranvar, Deepesh Kumar Gupta, Anishia Wasberg, Liangwen Liu, Joan Roig, Staffan Johansson
Summary: Integrin-mediated adhesion via FAK and PLK1 plays a crucial role in the regulation of the cell cycle, particularly in G2 and early M phases. Lack of FAK activity results in prolonged G2 phase and defective centrosome separation.
Article
Endocrinology & Metabolism
Aleix Gavalda-Navarro, Serena Mirra, Yasmina Manso, David Sanchez-Infantes, Marta Giralt, Eduardo Soriano, Francesc Villarroya
Summary: ARMCX3 is identified as a novel player in regulating the plasticity of thermogenic adipose tissue, acting to repress the acquisition of the browning phenotype and demonstrating a direct association with obesity indicators in mice and humans.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Multidisciplinary Sciences
Alba Vilchez-Acosta, Yasmina Manso, Adrian Cardenas, Alba Elias-Tersa, Magdalena Martinez-Losa, Marta Pascual, Manuel Alvarez-Dolado, Angus C. Nairn, Victor Borrell, Eduardo Soriano
Summary: The extracellular protein Reelin, derived from both CR cells and GABAergic interneurons, plays a crucial role in regulating the migration and positioning of cortical neurons during development. Disruptions in Reelin can lead to developmental disorders and neuropsychiatric disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Paula Izquierdo-Altarejos, Andrea Cabrera-Pastor, Mar Martinez-Garcia, Carlos Sanchez-Huertas, Alberto Hernandez, Victoria Moreno-Manzano, Vicente Felipo
Summary: Chronic hyperammonemia leads to neuroinflammation, causing cognitive impairment. Extracellular vesicles from mesenchymal stem cells can reduce neuroinflammation. In this study, it was found that treatment with these vesicles restores cognitive function in hyperammonemic rats and the underlying mechanism involves TGF beta signaling.
JOURNAL OF NEUROINFLAMMATION
(2023)
Editorial Material
Geriatrics & Gerontology
Mario Sanhueza, Yasmina Manso, Claudio Soto, Natalia Salvadores
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Nuria Gallisa-Sune, Paula Sanchez-Fernandez-de-Landa, Fabian Zimmermann, Marina Serna, Laura Regue, Joel Paz, Oscar Llorca, Jens Luders, Joan Roig
Summary: This study demonstrates that the adaptor protein BICD2 is activated through phosphorylation, which promotes the formation of the dynein motor complex and regulates its localization and activity within cells. This finding is crucial for understanding the functional importance of dynein in both dividing and non-dividing cells.
NATURE COMMUNICATIONS
(2023)
