Nucleating microtubules in neurons: Challenges and solutions

Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules

(2019) Yin-Wei Kuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patronin-mediated minus end growth is required for dendritic microtubule polarity

(2019) Chengye Feng et al.   JOURNAL OF CELL BIOLOGY

Microtubule nucleation in the cytoplasm of developing cortical neurons and its regulation by brain‐derived neurotrophic factor

(2019) Mimori Yamada et al.   Cytoskeleton

Microtubule control of functional architecture in neurons

(2019) Michael T Kelliher et al.   CURRENT OPINION IN NEUROBIOLOGY

Unconventional Roles of Cytoskeletal Mitotic Machinery in Neurodevelopment

(2019) Urko del Castillo et al.   TRENDS IN CELL BIOLOGY

Activity-Dependent Nucleation of Dynamic Microtubules at Presynaptic Boutons Controls Neurotransmission

(2019) Xiaoyi Qu et al.   CURRENT BIOLOGY

Cytoskeleton dynamics in axon regeneration

(2018) Oriane Blanquie et al.   CURRENT OPINION IN NEUROBIOLOGY

Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules

(2018) Jae-Geun Song et al.   JOURNAL OF CELL BIOLOGY

Microtubule-Organizing Centers: Towards a Minimal Parts List

(2018) Joel Paz et al.   TRENDS IN CELL BIOLOGY

The Role of the Microtubule Cytoskeleton in Neurodevelopmental Disorders

(2018) Micaela Lasser et al.   Frontiers in Cellular Neuroscience

Local microtubule organization promotes cargo transport in C. elegans dendrites

(2018) Martin Harterink et al.   JOURNAL OF CELL SCIENCE

The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development

(2018) Inês Cunha-Ferreira et al.   Cell Reports

Microtubule-severing enzymes: From cellular functions to molecular mechanism

(2018) Francis J. McNally et al.   JOURNAL OF CELL BIOLOGY

Of microtubules and memory: implications for microtubule dynamics in dendrites and spines

(2017) Erik W. Dent   MOLECULAR BIOLOGY OF THE CELL

The impact of cytoskeletal organization on the local regulation of neuronal transport

(2017) Jeffrey J. Nirschl et al.   NATURE REVIEWS NEUROSCIENCE

Differentiation between Oppositely Oriented Microtubules Controls Polarized Neuronal Transport

(2017) Roderick P. Tas et al.   NEURON

Cytoplasmic Dynein Transports Axonal Microtubules in a Polarity-Sorting Manner

(2017) Anand N. Rao et al.   Cell Reports

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

(2017) Amayra Hernández-Vega et al.   Cell Reports

Centriolar remodeling underlies basal body maturation during ciliogenesis in Caenorhabditis elegans

(2017) Inna V Nechipurenko et al.   eLife

Actin filament-microtubule interactions in axon initiation and branching

(2016) Almudena Pacheco et al.   BRAIN RESEARCH BULLETIN

Neuronal polarity: remodeling microtubule organization

(2016) Sam FB van Beuningen et al.   CURRENT OPINION IN NEUROBIOLOGY

Molecular Pathway of Microtubule Organization at the Golgi Apparatus

(2016) Jingchao Wu et al.   DEVELOPMENTAL CELL

Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation

(2016) K. W. Yau et al.   JOURNAL OF NEUROSCIENCE

Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity

(2016) Carlos Sánchez-Huertas et al.   Nature Communications

Loss of γ-tubulin, GCP-WD/NEDD1 and CDK5RAP2 from the Centrosome of Neurons in Developing Mouse Cerebral and Cerebellar Cortex

(2015) Satoshi Yonezawa et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Pavarotti/MKLP1 Regulates Microtubule Sliding and Neurite Outgrowth in Drosophila Neurons

(2015) Urko del Castillo et al.   CURRENT BIOLOGY

The Augmin Connection in the Geometry of Microtubule Networks

(2015) Carlos Sánchez-Huertas et al.   CURRENT BIOLOGY

Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization

(2015) Olga I. Kahn et al.   MOLECULAR BIOLOGY OF THE CELL

Centrosomin represses dendrite branching by orienting microtubule nucleation

(2015) Cagri Yalgin et al.   NATURE NEUROSCIENCE

Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons

(2015) Urko del Castillo et al.   eLife

Augmin Triggers Microtubule-Dependent Microtubule Nucleation in Interphase Plant Cells

(2014) Ting Liu et al.   CURRENT BIOLOGY

Neuronal polarization in vivo: Growing in a complex environment

(2014) Yasuhiro Funahashi et al.   CURRENT OPINION IN NEUROBIOLOGY

γ-Tubulin controls neuronal microtubule polarity independently of Golgi outposts

(2014) Michelle M. Nguyen et al.   MOLECULAR BIOLOGY OF THE CELL

Reconstitution of the augmin complex provides insights into its architecture and function

(2014) Kuo-Chiang Hsia et al.   NATURE CELL BIOLOGY

The dynamics of microtubule minus ends in the human mitotic spindle

(2014) Nicolas Lecland et al.   NATURE CELL BIOLOGY

Microtubule Minus-End Binding Protein CAMSAP2 Controls Axon Specification and Dendrite Development

(2014) Kah Wai Yau et al.   NEURON

Pioneering Axons Regulate Neuronal Polarization in the Developing Cerebral Cortex

(2014) Takashi Namba et al.   NEURON

The Microtubule Minus-End-Binding Protein Patronin/PTRN-1 Is Required for Axon Regeneration in C. elegans

(2014) Marian Chuang et al.   Cell Reports

PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons

(2014) Claire E Richardson et al.   eLife

The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites

(2014) Jana Dorfman Marcette et al.   eLife

Branching Microtubule Nucleation in Xenopus Egg Extracts Mediated by Augmin and TPX2

(2013) Sabine Petry et al.   CELL

Dynamics of Centrosome Translocation and Microtubule Organization in Neocortical Neurons during Distinct Modes of Polarization

(2013) Akira Sakakibara et al.   CEREBRAL CORTEX

Initial Neurite Outgrowth in Drosophila Neurons Is Driven by Kinesin-Powered Microtubule Sliding

(2013) Wen Lu et al.   CURRENT BIOLOGY

Augmin-dependent microtubule nucleation at microtubule walls in the spindle

(2013) Tomoko Kamasaki et al.   JOURNAL OF CELL BIOLOGY

Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans

(2013) Jing Yan et al.   eLife

Excitatory Cortical Neurons with Multipolar Shape Establish Neuronal Polarity by Forming a Tangentially Oriented Axon in the Intermediate Zone

(2012) Yumiko Hatanaka et al.   CEREBRAL CORTEX

Cyclin-Dependent Kinase 5 Regulates the Polarized Trafficking of Neuropeptide-Containing Dense-Core Vesicles in Caenorhabditis elegans Motor Neurons

(2012) P. R. Goodwin et al.   JOURNAL OF NEUROSCIENCE

Mitotic Motors Coregulate Microtubule Patterns in Axons and Dendrites

(2012) S. Lin et al.   JOURNAL OF NEUROSCIENCE

Development of dendrite polarity in Drosophila neurons

(2012) Sarah E Hill et al.   Neural Development

Golgi Outposts Shape Dendrite Morphology by Functioning as Sites of Acentrosomal Microtubule Nucleation in Neurons

(2012) Kassandra M. Ori-McKenney et al.   NEURON

Microtubules are organized independently from the centrosome in Drosophila neurons

(2011) Michelle M Nguyen et al.   Neural Development

Patronin Regulates the Microtubule Network by Protecting Microtubule Minus Ends

(2010) Sarah S. Goodwin et al.   CELL

Hooks and comets: The story of microtubule polarity orientation in the neuron

(2010) Peter W. Baas et al.   Developmental Neurobiology

Axon Extension Occurs Independently of Centrosomal Microtubule Nucleation

(2010) M. Stiess et al.   SCIENCE

Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130

(2009) Sabrina Rivero et al.   EMBO JOURNAL

Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle

(2008) Gohta Goshima et al.   JOURNAL OF CELL BIOLOGY

Microtubule stabilization specifies initial neuronal polarization

(2008) Harald Witte et al.   JOURNAL OF CELL BIOLOGY

Microtubules Have Opposite Orientation in Axons and Dendrites of Drosophila Neurons

(2008) Michelle C. Stone et al.   MOLECULAR BIOLOGY OF THE CELL

The Microtubule-severing Proteins Spastin and Katanin Participate Differently in the Formation of Axonal Branches

(2008) Wenqian Yu et al.   MOLECULAR BIOLOGY OF THE CELL