The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization

PLA2G6 accumulates in Lewy bodies in PARK14 and idiopathic Parkinson's disease

(2017) Yasuo Miki et al.   NEUROSCIENCE LETTERS

Calcium-independent phospholipases A2and their roles in biological processes and diseases

(2015) Sasanka Ramanadham et al.   JOURNAL OF LIPID RESEARCH

Inhibition of Ca2+-Independent Phospholipase A2β (iPLA2β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice

(2014) Robert N. Bone et al.   DIABETES

Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis

(2014) Wolfgang Stremmel et al.   FASEB JOURNAL

Crystal Structure of Patatin-17 in Complex with Aged and Non-Aged Organophosphorus Compounds

(2014) Sanjeeva J. Wijeyesakere et al.   PLoS One

New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2

(2013) Victoria Magrioti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New Findings in a Global Approach to Dissect the Whole Phenotype of PLA2G6 Gene Mutations

(2013) Mustafa A. Salih et al.   PLoS One

Genetic modulation of islet β-cell iPLA2β expression provides evidence for its impact on β-cell apoptosis and autophagy

(2013) Xiaoyong Lei et al.   Islets

Using Hydrogen/Deuterium Exchange Mass Spectrometry to Define the Specific Interactions of the Phospholipase A2Superfamily with Lipid Substrates, Inhibitors, and Membranes

(2012) Jian Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluoroketone Inhibition of Ca2+-Independent Phospholipase A2 through Binding Pocket Association Defined by Hydrogen/Deuterium Exchange and Molecular Dynamics

(2012) Yuan-Hao Hsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of PLA2G6 gene mutation in sporadic early-onset parkinsonism patients from Chinese population

(2012) Jin-yong Tian et al.   NEUROSCIENCE LETTERS

Four novel rare mutations of PLA2G6 in Chinese population with Parkinson's disease

(2012) Ya-Xing Gui et al.   PARKINSONISM & RELATED DISORDERS

Structural Basis for Calmodulin as a Dynamic Calcium Sensor

(2012) Miao Zhang et al.   STRUCTURE

PLA2G6 mutations in PARK14-linked young-onset parkinsonism and sporadic Parkinson's disease

(2011) Chin-Song Lu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Platelet-activating factor and metastasis: calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung

(2011) Jane McHowat et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells

(2011) Bo Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Automated sample-scanning methods for radiation damage mitigation and diffraction-based centering of macromolecular crystals

(2011) Mark C. Hilgart et al.   JOURNAL OF SYNCHROTRON RADIATION

The PLA2G6 gene in early-onset Parkinson's disease

(2011) Kai Michael Kauther et al.   MOVEMENT DISORDERS

PLA2G6 gene mutation in autosomal recessive early-onset parkinsonism in a Chinese cohort

(2011) C.- h. Shi et al.   NEUROLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Group VIA Ca2+-independent phospholipase A2 (iPLA2β) and its role in β-cell programmed cell death

(2010) Xiaoyong Lei et al.   BIOCHIMIE

Novel splice-site mutations and a large intragenic deletion inPLA2G6associated with a severe and rapidly progressive form of infantile neuroaxonal dystrophy

(2010) A Tonelli et al.   CLINICAL GENETICS

Effects of Endoplasmic Reticulum Stress on Group VIA Phospholipase A2in Beta Cells Include Tyrosine Phosphorylation and Increased Association with Calnexin

(2010) Haowei Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-Independent Phospholipase A2

(2010) George Kokotos et al.   JOURNAL OF MEDICINAL CHEMISTRY

ADP Ribosylation Factors 1 and 4 and Group VIA Phospholipase A2 Regulate Morphology and Intraorganellar Traffic in the Endoplasmic Reticulum–Golgi Intermediate Compartment

(2010) Houchaima Ben-Tekaya et al.   MOLECULAR BIOLOGY OF THE CELL

Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations

(2010) Coro Paisán-Ruiz et al.   MOVEMENT DISORDERS

Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations

(2010) Coro Paisán-Ruiz et al.   NEUROBIOLOGY OF AGING

Phenotypic spectrum of patients with PLA2G6 mutation and PARK14-linked parkinsonism

(2010) H. Yoshino et al.   NEUROLOGY

Catalytic Function of PLA2G6 Is Impaired by Mutations Associated with Infantile Neuroaxonal Dystrophy but Not Dystonia-Parkinsonism

(2010) Laura A. Engel et al.   PLoS One

Tumor cell group via phospholipase A2 is involved in prostate cancer development

(2010) Hui Li et al.   PROSTATE

Phospholipase A2-derived lysophosphatidylcholine triggers Ca2+ entry in dystrophic skeletal muscle fibers

(2009) François-Xavier Boittin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis

(2009) Athena Kalyvas et al.   BRAIN

Localizing the Membrane Binding Region of Group VIA Ca2+-independent Phospholipase A2Using Peptide Amide Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) Yuan-Hao Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of PLA2G6 as a locus for dystonia-parkinsonism

(2008) Coro Paisan-Ruiz et al.   ANNALS OF NEUROLOGY

Eicosanoid signalling pathways in the heart

(2008) C. M. Jenkins et al.   CARDIOVASCULAR RESEARCH

R632W mutation inPLA2G6segregates with dystonia-parkinsonism in a consanguineous Iranian family

(2008) F. Sina et al.   EUROPEAN JOURNAL OF NEUROLOGY

Smooth Muscle Cell Arachidonic Acid Release, Migration, and Proliferation Are Markedly Attenuated in Mice Null for Calcium-independent Phospholipase A2β

(2008) Sung Ho Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase A2structure/function, mechanism, and signaling

(2008) John E. Burke et al.   JOURNAL OF LIPID RESEARCH