Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology

Distinct roles of T-cell lymphopenia and the microbial flora for gastrointestinal and CNS autoimmunity

(2016) Henrike J. Fischer et al.   FASEB JOURNAL

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

(2016) Katherine C. Verbist et al.   NATURE

TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5)

(2016) Xi-Lin Chen et al.   PLoS One

Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response

(2016) Tina M. Thornton et al.   Nature Communications

Glycogen synthase kinase 3β inhibition promotes human iTreg differentiation and suppressive function

(2015) Yongxiang Xia et al.   IMMUNOLOGIC RESEARCH

GIMAP GTPase Family Genes: Potential Modifiers in Autoimmune Diabetes, Asthma, and Allergy

(2015) Mirkka T. Heinonen et al.   JOURNAL OF IMMUNOLOGY

Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis

(2015) Stacey N. Harbour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Catenin Promotes Colitis and Colon Cancer Through Imprinting of Proinflammatory Properties in T Cells

(2014) S. Keerthivasan et al.   Science Translational Medicine

Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

(2014) Jennifer L Stamos et al.   eLife

Mcl-1 antagonizes Bax/Bak to promote effector CD4+ and CD8+ T-cell responses

(2013) P Tripathi et al.   CELL DEATH AND DIFFERENTIATION

Canonical Wnt Signaling Negatively Modulates Regulatory T Cell Function

(2013) Jorg van Loosdregt et al.   IMMUNITY

Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3

(2013) E. Beurel et al.   JOURNAL OF IMMUNOLOGY

The Wnt inhibitor secreted Frizzled-Related Protein 1 (sFRP1) promotes human Th17 differentiation

(2012) Yoon-Sook Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

(2011) Pawel Muranski et al.   IMMUNITY

Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells

(2011) Yuhong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of Immunological Tolerance in Gimap5-Deficient Mice Is Associated with Loss of Foxo in CD4+ T Cells

(2011) H. I. Aksoylar et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53

(2011) Céline Charvet et al.   MOLECULAR CELL

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles

(2011) Radek Dobrowolski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glycogen synthase kinase 3β inhibition enhances repair of DNA double-strand breaks in irradiated hippocampal neurons

(2011) Eddy S. Yang et al.   NEURO-ONCOLOGY

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

Suppressive Regulatory T Cell Activity Is Potentiated by Glycogen Synthase Kinase 3β Inhibition

(2010) Jay A. Graham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 1 Diabetes in BioBreeding Rats Is Critically Linked to an Imbalance between Th17 and Regulatory T Cells and an Altered TCR Repertoire

(2010) J. van den Brandt et al.   JOURNAL OF IMMUNOLOGY

Glycogen Synthase Kinase-3 Is an Early Determinant in the Differentiation of Pathogenic Th17 Cells

(2010) E. Beurel et al.   JOURNAL OF IMMUNOLOGY

Loss of T Cell and B Cell Quiescence Precedes the Onset of Microbial Flora-Dependent Wasting Disease and Intestinal Inflammation in Gimap5-Deficient Mice

(2010) M. J. Barnes et al.   JOURNAL OF IMMUNOLOGY

Stabilisation of β-Catenin Downstream of T Cell Receptor Signalling

(2010) Matthew Lovatt et al.   PLoS One

Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2)

(2010) D. Schwefel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

IAN5 polymorphisms are associated with systemic lupus erythematosus

(2009) MK Lim et al.   LUPUS

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5

(2008) R. D. Schulteis et al.   BLOOD

Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes

(2008) Katrina MacAulay et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Tissue-Specific Role of Glycogen Synthase Kinase 3  in Glucose Homeostasis and Insulin Action

(2008) S. Patel et al.   MOLECULAR AND CELLULAR BIOLOGY

Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells

(2008) Yi Ding et al.   NATURE MEDICINE

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

(2008) Shunfu Piao et al.   PLoS One