Article
Biochemistry & Molecular Biology
You-Joung Kim, Sooyeon Park, Taejeong Ha, Seungbeom Kim, Soyeon Lim, Han You, Jin Woo Kim
Summary: The study found that decreased levels of retinol dehydrogenases (RDHs) in Pten-deficient mouse RPE lead to degeneration, which can be rescued by a ROL-free diet. It was also discovered that RDH gene expression is regulated by forkhead box O (FOXO) transcription factors, which are inactivated by hyperactive Akt in the Pten-deficient mouse RPE.
MOLECULES AND CELLS
(2021)
Article
Medicine, Research & Experimental
Colin Carlock, Yunpeng Bai, Allison Paige-Hood, Qinglin Li, Frederick Nguele Meke, Zhong-Yin Zhang
Summary: Overexpression of PRL2 and reduced PTEN protein are frequently observed in patients with acute myeloid leukemia (AML). Inhibiting PRL2 can prolong animal survival and slow the accumulation of leukemia blasts in the bone marrow niche. This study provides evidence for the viability of PRL2 inhibition as a therapeutic strategy for improving clinical outcomes in AML and other PTEN-deficient cancers.
Article
Clinical Neurology
Jiaxu Wang, Meng Li, Jing Zhang, Qing Gao, Zhaoxi Ding, Jinhao Sun
Summary: The aim of this animal study was to investigate the mechanisms underlying the efficacy of paliperidone, an antipsychotic drug approved by the US FDA for the treatment of schizophrenia. The results showed that paliperidone alleviated neuronal damage induced by MK-801 through the PP2A/PTEN pathway.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biotechnology & Applied Microbiology
Nianxue Wang, Bin Yang, Jiao Jin, Yu He, Xijun Wu, Yichen Yang, Weijun Zhou, Zhixu He
Summary: This study identified circ_0040823/miR-516b/PTEN as a new therapeutic target for AML, as circ_0040823 inhibited proliferation and induced apoptosis of AML cells by sponging miR-516b, thereby diminishing the regulatory effect of miR-516b on PTEN.
JOURNAL OF GENE MEDICINE
(2022)
Article
Engineering, Mechanical
Nan Liu, Hongli Yang, Shasha Li, Danni Wang, Liangui Yang
Summary: The team constructed a coupling model involving p53-Mdm2 negative feedback loop and p53-PTEN-Mdm2 positive feedback loop, finding that PTEN is crucial for p53 oscillation or bistable switching dynamic behaviors, and the positive feedback loop may enrich the dynamic behaviors of the p53 system.
ACTA MECHANICA SINICA
(2021)
Article
Medicine, Research & Experimental
Gefei Wu, Jiasheng Hu, Hongmin Zhu, Shuhua Wu, Sheng Huang, Zhisheng Liu
Summary: The study demonstrated the therapeutic effect of melatonin (MT) on febrile convulsion (FC) by modulating the MEG3/miR-223/PTEN/AKT pathway, suggesting MT as a novel strategy for FC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Tiezhong Yi, Yicun Song, Lingling Zuo, Siyun Wang, Jintian Miao
Summary: Researches have found that LINC00470 is upregulated in endometrial cancer and correlates with patient prognosis. LINC00470 promotes the invasiveness, migration, and angiogenesis of endometrial cancer cells, and facilitates tumor formation and metastasis in vivo, effects that can be reversed by upregulating PTEN. Furthermore, LINC00470 stimulates PTEN methylation through MYC-induced recruitment of DNMT3a, exacerbating the progression of endometrial cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Chiao-Yun Lin, Ren-Chin Wu, Lan-Yan Yang, Shih-Ming Jung, Shir-Hwa Ueng, Yun-Hsin Tang, Huei-Jean Huang, Hsiu-Jung Tung, Cheng-Tao Lin, Hsuan-Yu Chen, Angel Chao, Chyong-Huey Lai
Summary: Diagnostic agreement among pathologists for endometrial hyperplasia is poor. This study identified miR-30a-3p, miR-141, miR-200a, miR-200b, and complete PTEN loss as useful tissue biomarkers for predicting endometrial cancer risk in patients with simple or complex hyperplasia without atypia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Huizhen Wang, Yifan Wang, Xin Wang, Huimi Huang, Jingfu Bao, Wenhui Zhong, Aiqing Li
Summary: PTEN plays a crucial role in renal adaptive repair by upregulating CHMP2A to alleviate cell damage, apoptosis, and renal fibrosis. PTEN overexpression promotes phagosome closure, providing a potential therapeutic target for the transition from AKI to CKD.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Ming Ye, Hui Wu, Shuguo Li
Summary: Resveratrol exerts neuroprotective effects on primary cortical neurons subjected to oxygen/glucose deprivation/reoxygenation (OGD/R) by modulating mitophagy, improving cell viability, suppressing apoptosis, alleviating loss of mitochondrial membrane potential and excessive oxidative stress. The protective effects are mediated, at least in part, by promoting mitophagy through the PTEN-induced kinase 1/Parkin pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Immunology
Tingkai Fu, Yunxue Yang, Zhenxin Mu, Rongwei Sun, Xingang Li, Jun Dong
Summary: The study found that upregulation of LINC01410 in GBM cells promoted cell viability, while its silencing decreased viability. In TMZ-resistant GBM cells, increased expression of LINC01410 and drug resistance-related factors was observed, along with a decreased cell viability trend. However, silencing LINC01410 decreased the IC50 value, increased sensitivity and apoptosis in resistant cells, and led to upregulation of PTEN and downregulation of phosphorylated AKT.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Zhongwei Zhang, Caiping Song, Tao Wang, Lei Sun, Ling Qin, Jianghua Ju
Summary: The study found that miR-139-5p promotes retinal neovascularization by suppressing PTEN expression. High glucose treatment increases miR-139-5p levels, leading to enhanced cell migration, tube formation, and VEGF protein levels.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Jinxin Tang, Jieyu He, Chengyao Feng, Chao Tu
Summary: MiRNAs are non-coding RNA molecules that play important roles in cancer. Recent studies have shown that exosomal miRNAs play crucial roles in tumor initiation and progression, and have potential diagnostic and therapeutic functions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhenze Lu, Ling Li, Lei Wei, Jifu Cai, Jun Wu
Summary: This study revealed that LOC366613 plays a crucial role in cerebral I/R injury by regulating the miR-532-5p/PTEN axis, mediating biological functions such as cell apoptosis, cell survival, and LDH release.
Article
Medicine, Research & Experimental
Yonghua Lei, Ming Yang, Hong Li, Rongjuan Xu, Junbao Liu
Summary: The study revealed that miR-130b is downregulated in diabetic encephalopathy, and exerts a protective effect against oxidative stress injury by activating the PI3K/Akt signaling pathway through regulating PTEN.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Physics, Applied
Ruoyu Zeng, Qi Zhao, Yijie Shen, Yidong Liu, Yuanjie Yang
Summary: This study examines the structural stability of open vortex beams (OVBs) and their potential applications in optical manipulation, optical metrology, etc., through a theoretical model and experimental validation.
APPLIED PHYSICS LETTERS
(2021)
Article
Engineering, Electrical & Electronic
Chuanhui Hao, Yidong Liu, Xiaohui Wang, Xubao Sun
Summary: The paper proposes an adaptive anti-jamming dual-polarized ellipsoid minimum variance distortionless response (EMVDR) method for evaluating GPS signal coverage, which outperforms the classic minimum variance distortionless response (MVDR) method according to Monte Carlo simulations.
IEEE SENSORS JOURNAL
(2021)
Article
Genetics & Heredity
Mingzhu Huo, Yile Zhang, Senlin Shi, Hao Shi, Yidong Liu, Lingyun Zhang, Yanchi Wang, Wenbin Niu
Summary: This study examined nine patients with oocyte maturation arrest and identified nine pathogenic variants in five genes, including three novel variants. These findings expand the understanding of the gene variant spectrum and provide insights for genetic diagnosis and prediction of oocyte maturation arrest.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Yidong Liu, Emma Leary, Obai Saffaf, R. Frank Baker, Shuqun Zhang
Summary: In this study, the researchers found that Arabidopsis MAPK3 and MPK6 play important roles in plant immunity and growth/development. YDA, along with MAPKKK3 and MAPKKK5, serves as an upstream regulator of the MAPK cascade, regulating plant growth and development. The study also demonstrated the involvement of YDA in plant immune signaling, and the contribution of MAPKKK3 and MAPKKK5 to gamete function and embryogenesis.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Chuanhui Hao, Yidong Liu, Hongmei Zheng, Xu-bao Sun
Summary: This paper studies a practical scheme to reduce mutual coupling interference (MCI) between two extremely adjacent multiple input multiple output (MIMO) antenna elements. By using special two-dimensional metamaterial units, the surface wave interference is successfully suppressed. The proposed scheme is validated through experimental and simulation results, which show that the MCI of the antenna array is effectively reduced and exhibits good performance at the interested frequencies.
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
(2022)
Article
Food Science & Technology
Mingyue Zhao, Fengxian Tang, Wenchao Cai, Yidong Liu, Chunhui Shan
Summary: This study investigated the impact of hot brewing, room temperature brewing, and cold brewing on Apocynum venetum tea. The results showed that hot brewing is the best method for producing high-quality A. venetum tea, while cold brewing resulted in tea with a unique color and aroma. The brewing conditions affected the physicochemical indexes, functional components, antioxidant activity, and aroma compounds of the tea.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Microbiology
Yidong Liu, Wenxuan Sun, Liting Ma, Rong Xu, Chunyu Yang, Ping Xu, Cuiqing Ma, Chao Gao
Summary: Given the intrinsic and potential resistance of Pseudomonas aeruginosa to antibiotics, it is crucial to develop new therapeutic options for infections caused by this bacterium. Bacterial metabolic pathways are being explored as potential targets for new antibiotics. This study investigates the metabolic mechanisms of glycerol and its intermediate glycerol 3-phosphate (G3P) in P. aeruginosa PAO1. The results reveal the importance of G3P homeostasis for the growth and virulence factor production of P. aeruginosa PAO1. The enzyme GlpD, involved in G3P catabolism, is identified as a potential therapeutic target for the prevention and treatment of P. aeruginosa infections.
Article
Computer Science, Information Systems
Yidong Liu, Xihong Chen, Dizhe Yuan, Denghua Hu
Summary: This paper presents a novel nonlinear frequency domain equalization algorithm for SC-FDE systems. The algorithm improves the classical iterative block decision feedback equalization (IBDFE) algorithm by replacing ZF equalization with MMSE equalization and eliminating the iteration of the correlation factor. Delta estimation is also applied to improve equalization accuracy. Simulation results show that the performance of the novel algorithm is better or the complexity is lower than the IBDFE algorithm with similar complexity or performance.
Article
Optics
Jiadian Yan, Jun Yao, Yidong Liu, Yuanjie Yang
Summary: Newton's rings are interference patterns consisting of concentric rings, commonly observed in classic optics experiments. In this study, we demonstrate the generation of generalized Newton's rings using vortex beams. Unlike conventional Newton's rings, the generalized ones exhibit spiral arms instead of concentric rings, accompanied by fork-shaped dislocations. Notably, the number of spiral arms and dislocations corresponds to the topological charge of the incident vortex beams. Experimental results confirm our theoretical predictions. This novel interference pattern can be utilized for measuring the topological charge of vortex beams.
Article
Andrology
Yanping Huang, Wei Liu, Yidong Liu, Ming Zhang, Xiangguo Lv, Kai Hu, Shiran Xu, Mujun Lu
Summary: Glycated serum albumin (GSA) decreases the expression of phosphorylated connexin 43 (p-Cx43) in the corpus cavernosum of rats. This effect might be related to the decreased phosphorylation of p-eNOS, p-PI3K, and p-Akt, as well as the downregulation of phosphorylation at the S368 site.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2022)
Article
Surgery
Chengjiang Liu, Yidong Liu, Boyuan Ma, Mengmeng Zhou, Xinyan Zhao, Xuanhao Fu, Shunli Kan, Wei Hu, Rusen Zhu
Summary: Anterior cervical discectomy and fusion (ACDF) is a common surgery for cervical diseases, with low infection rates and rare involvement of adjacent segments. Tuberculosis (TB) is a common infectious disease that rarely affects the cervical spine. Here, we report a case of tuberculosis infection in adjacent segments after ACDF for the first time.
FRONTIERS IN SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Yunzhe Jiang, Yidong Liu, Sylvain Grosjean, Volodymyr Bon, Patrick Hodapp, Anemar Bruno Kanj, Stefan Kaskel, Stefan Braese, Christof Woell, Lars Heinke
Summary: In this research, we achieved a directed responsive behavior of light-induced deformation by assembling light-powered molecules into a surface-mounted metal-organic framework film. The molecular extension changes were multiplied at the mesoscopic scale and transferred to the macroscopic scale, resulting in the bending of a cantilever and performing work.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Electrical & Electronic
Liu Yidong, Jia Zhentang
Summary: The article describes an improved particle swarm optimization camera parameter calibration method that dynamically adjusts the inertia weight of the group and adapts the optimal particle variation to improve calibration accuracy and search ability. Experimental results show that the algorithm has advantages.
LASER & OPTOELECTRONICS PROGRESS
(2022)
Review
Medicine, General & Internal
Chengjiang Liu, Yidong Liu, Boyuan Ma, Mengmeng Zhou, Xinyan Zhao, Xuanhao Fu, Shunli Kan, Wei Hu, Rusen Zhu
Summary: Spinal cord injury is a severe injury to the central nervous system, resulting in permanent loss of motor, sensory, and autonomic functions below the level of injury. Secondary injury impairs mitochondrial function and exacerbates the damage. Therapeutic strategies aimed at preserving mitochondrial function show promise but are still underexplored.
Article
Clinical Neurology
Hu Wei, Kan Shunli, Jiang Zehua, Zhang Tengfei, Liu Yidong, Zhu Rusen
Summary: This study retrospectively analyzed 8 cases of ASD cervical spondylopathy treated with ACCF, and showed significant improvements in clinical outcomes with the use of self-locking stand-alone cage. The method was considered reliable and effective in terms of JOA and NDI scores, as well as cervical alignment correction.
TURKISH NEUROSURGERY
(2021)
