Article
Biology
Lingli Huang, Wenqing Li, Xingxing Dai, Shuai Zhao, Bo Xu, Fengsong Wang, Ren-Tao Jin, Lihua Luo, Limin Wu, Xue Jiang, Yu Cheng, Jiaqi Zou, Caoling Xu, Xianhong Tong, Heng-Yu Fan, Han Zhao, Jianqiang Bao
Summary: This study identified and characterized novel biallelic variants in MAD2L1BP responsible for oocyte maturation arrest at MI, providing new therapeutic avenues for female primary infertility.
Article
Reproductive Biology
Chao Lv, Hua-Lin Huang, Da-Jing Yi, Tian-Liu Peng, Hang-Jing Tan, Ru-Ping Quan, Hong-Wen Deng, Hong-Mei Xiao
Summary: This study found that a mutation in the Zp1 gene resulted in the absence of ZP in rat oocytes, leading to infertility and loss of fertilization capacity.
BIOLOGY OF REPRODUCTION
(2021)
Article
Medicine, Research & Experimental
Weijie Wang, Jing Guo, Juanzi Shi, Qun Li, Biaobang Chen, Zhiqi Pan, Ronggui Qu, Jing Fu, Rong Shi, Xia Xue, Jian Mu, Zhihua Zhang, Tianyu Wu, Wenjing Wang, Lin Zhao, Qiaoli Li, Lin He, Xiaoxi Sun, Qing Sang, Ge Lin, Lei Wang
Summary: PABPC1L gene variants are responsible for female infertility characterized by oocyte maturation arrest. These variants result in truncated proteins, reduced abundance, altered localization, and decreased mRNA translational activation. PABPC1L plays an important role in human oocyte maturation and could be a potential candidate gene for infertility causes.
EMBO MOLECULAR MEDICINE
(2023)
Article
Obstetrics & Gynecology
Ping Yang, Tailai Chen, Yuqing Liu, Zhenzhen Hou, Keliang Wu, Yongzhi Cao, Jiangtao Zhang, Zhao Wang, Han Zhao
Summary: Novel variants of ZP genes were identified in over half of the cohort with GEFS and oocyte degeneration, causing intracellular protein sequestration and failure to assemble ZP filaments, resulting in EFS and female infertility.
FERTILITY AND STERILITY
(2021)
Article
Cell Biology
Lin Zhao, Yichun Guan, Qingxia Meng, Weijie Wang, Ling Wu, Biaobang Chen, Jijun Hu, Jiawei Zhu, Zhihua Zhang, Jian Mu, Yao Chen, Yiming Sun, Tianyu Wu, Wenjing Wang, Zhou Zhou, Jie Dong, Yang Zeng, Ruyi Liu, Qiaoli Li, Jing Du, Yanping Kuang, Qing Sang, Lei Wang
Summary: Mutations in the CDC20 gene play a crucial role in oocyte maturation and fertilization, leading to various infertility phenotypes. This study expands the spectrum of known mutations in CDC20 and provides new evidence for its involvement in female infertility characterized by oocyte maturation arrest and fertilization failure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Lin Zhao, Qun Li, Yanping Kuang, Peng Xu, Xiaoxi Sun, Qingxia Meng, Wenjing Wang, Yang Zeng, Biaobang Chen, Jing Fu, Jie Dong, Jiawei Zhu, Yuxi Luo, Hao Gu, Caihong Li, Chunyi Li, Ling Wu, Xiaoyan Mao, Huizhen Fan, Ruyi Liu, Zhihua Zhang, Qiaoli Li, Jing Du, Lin He, Li Jin, Lei Wang, Qing Sang
Summary: This study identified a novel pathogenic gene LHX8 through a gene-based burden test and established the causative relationship between LHX8 haploinsufficiency and female infertility characterized by oocyte maturation arrest.
GENETICS IN MEDICINE
(2022)
Article
Reproductive Biology
Ming-Hua Zeng, Yan Wang, Hua-Lin Huang, Ru-Ping Quan, Jun-Ting Yang, Dan Guo, Ying Sun, Chao Lv, Tian-Ying Li, Le Wang, Hang-Jin Tan, Pan-Pan Long, Hong-Wen Deng, Hong-Mei Xiao
Summary: The zona pellucida (ZP) is essential for female fertility in mammals, with ZP1-3 playing important roles. However, the function of ZP4 remains poorly understood. A study on Zp4 knockout (KO) rats found that Zp4 was dispensable for female fertility, as it did not affect ZP morphology or reproductive processes.
BIOLOGY OF REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Meiqi Hou, Lixia Zhu, Jinghang Jiang, Zhenxing Liu, Zhou Li, Weimin Jia, Juan Hu, Xiaopei Zhou, Dazhi Zhang, Yalin Luo, Xuejie Peng, Qingsong Xi, Lei Jin, Xianqin Zhang
Summary: This study identified two novel mutations in the ZP2 gene associated with abnormal ZP and female infertility, and demonstrated their impact on protein expression and function through cell experiments and protein analysis.
REPRODUCTIVE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Lixia Zhu, Qiyu Yang, Huizi Jin, Juepu Zhou, Meng Wang, Liu Yang, Zhou Li, Kun Qian, Lei Jin
Summary: This study identified different phenotypes in patients with oocyte maturation arrest (OMA), and found that clinical outcomes were associated with the presence of gene mutations and the classification of oocyte phenotypes. A triage system was proposed to optimize resource allocation and maximize patient benefit.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Tingting Lin, Weiwei Liu, Wei Han, Keya Tong, Yezhou Xiang, Haiyuan Liao, Ke Chen, Yao He, Dongyun Liu, Guoning Huang
Summary: The study investigates the correlation between phenotypic diversity and genetic variability in the TUBB8 gene in infertile women. Through resequencing and analysis, several TUBB8 variants were identified and found to be associated with different phenotypes related to female infertility. These findings contribute to the understanding of the genetic basis of infertility and may have implications for genetic counseling.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Biology
Paul M. Wassarman, Eveline S. Litscher
Summary: The presence of a zona pellucida (ZP) is essential for the fertility of female mammals, including mice and humans. It stabilizes the contacts between oocyte microvilli and follicle cell projections, supporting the development of growing oocytes and follicles. The absence of a ZP, due to gene inactivation or mutation, results in a loss of contacts and reduced production of ovulated eggs, leading to female infertility.
Article
Genetics & Heredity
Qian Dou, HongEn Xu, LiYing Ma, Li Tan, WenXue Tang
Summary: TUBB8 is a protein expressed exclusively in the oocyte and early embryo, participating in microtubule assembly. This study reports two siblings with TUBB8 variants who showed different clinical features of primary infertility. The variant was found to be pathogenic and related to the phenotype in the patients.
BMC MEDICAL GENOMICS
(2023)
Article
Obstetrics & Gynecology
Lingli Huang, Fengsong Wang, Shuai Kong, Yu Wang, Gaojie Song, Fangting Lu, Jingjuan Ji, Lihua Luo, Xianhong Tong
Summary: This study identified two novel mutations in CDC20, expanding the mutation spectrum of this gene. Biallelic mutations in CDC20 occur in a proportion of infertile females with oocyte maturation abnormality and early embryonic arrest, as confirmed by the findings.
REPRODUCTIVE SCIENCES
(2021)
Article
Genetics & Heredity
Yiming Sun, Yang Zeng, Hua Chen, Zhou Zhou, Jing Fu, Qing Sang, Lei Wang, Xiaoxi Sun, Biaobang Chen, Congjian Xu
Summary: This study identified a novel pathogenic variant in ZP2 that may cause thin ZP and female infertility. The variant affects the assembly of ZP2-ZP3 dimers, and further experimental results confirmed this mechanism of action.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Obstetrics & Gynecology
Wenzhu Yu, Shaodi Zhang, Baoli Yin, Chang Dong, Victor Wei Zhang, Cuilian Zhang
Summary: TUBB8 is a disease-causing gene in female infertility, and this study identified novel heterozygous missense variants in TUBB8 gene in four families, expanding the mutational spectrum and confirming its diagnostic utility in female infertility.
REPRODUCTIVE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zhaoqi Kang, Manman Zhang, Kaiyu Gao, Wen Zhang, Wensi Meng, Yidong Liu, Dan Xiao, Shiting Guo, Cuiqing Ma, Chao Gao, Ping Xu
Summary: l-2-Hydroxyglutarate (l-2-HG) is a key metabolite involved in various physiological processes, but its regulation remains poorly understood. A novel l-2-HG FRET biosensor based on the allosteric transcription factor LhgR has been developed to monitor l-2-HG levels in cells and biological samples, revealing new insights into its roles in bacterial and human cells.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yipeng Zhang, Yidong Liu, Jieni Zhu, Dan Xiao, Ping Xu, Cuiqing Ma, Chao Gao, Chuanjuan Lu
Summary: 3,4-Dihydroxybutyric acid (3,4-DHBA) is an important platform chemical with versatile applications, but traditional chemical production methods are environmentally unfriendly. This study developed a coculture system using Gluconobacter oxydans and Escherichia coli for efficient biosynthesis of 3,4-DHBA from xylose, achieving the highest reported titer and yield.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Yidong Liu, Emma Leary, Obai Saffaf, R. Frank Baker, Shuqun Zhang
Summary: In this study, the researchers found that Arabidopsis MAPK3 and MPK6 play important roles in plant immunity and growth/development. YDA, along with MAPKKK3 and MAPKKK5, serves as an upstream regulator of the MAPK cascade, regulating plant growth and development. The study also demonstrated the involvement of YDA in plant immune signaling, and the contribution of MAPKKK3 and MAPKKK5 to gamete function and embryogenesis.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Chuanhui Hao, Yidong Liu, Hongmei Zheng, Xu-bao Sun
Summary: This paper studies a practical scheme to reduce mutual coupling interference (MCI) between two extremely adjacent multiple input multiple output (MIMO) antenna elements. By using special two-dimensional metamaterial units, the surface wave interference is successfully suppressed. The proposed scheme is validated through experimental and simulation results, which show that the MCI of the antenna array is effectively reduced and exhibits good performance at the interested frequencies.
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
(2022)
Article
Food Science & Technology
Mingyue Zhao, Fengxian Tang, Wenchao Cai, Yidong Liu, Chunhui Shan
Summary: This study investigated the impact of hot brewing, room temperature brewing, and cold brewing on Apocynum venetum tea. The results showed that hot brewing is the best method for producing high-quality A. venetum tea, while cold brewing resulted in tea with a unique color and aroma. The brewing conditions affected the physicochemical indexes, functional components, antioxidant activity, and aroma compounds of the tea.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Microbiology
Yidong Liu, Wenxuan Sun, Liting Ma, Rong Xu, Chunyu Yang, Ping Xu, Cuiqing Ma, Chao Gao
Summary: Given the intrinsic and potential resistance of Pseudomonas aeruginosa to antibiotics, it is crucial to develop new therapeutic options for infections caused by this bacterium. Bacterial metabolic pathways are being explored as potential targets for new antibiotics. This study investigates the metabolic mechanisms of glycerol and its intermediate glycerol 3-phosphate (G3P) in P. aeruginosa PAO1. The results reveal the importance of G3P homeostasis for the growth and virulence factor production of P. aeruginosa PAO1. The enzyme GlpD, involved in G3P catabolism, is identified as a potential therapeutic target for the prevention and treatment of P. aeruginosa infections.
Article
Computer Science, Information Systems
Yidong Liu, Xihong Chen, Dizhe Yuan, Denghua Hu
Summary: This paper presents a novel nonlinear frequency domain equalization algorithm for SC-FDE systems. The algorithm improves the classical iterative block decision feedback equalization (IBDFE) algorithm by replacing ZF equalization with MMSE equalization and eliminating the iteration of the correlation factor. Delta estimation is also applied to improve equalization accuracy. Simulation results show that the performance of the novel algorithm is better or the complexity is lower than the IBDFE algorithm with similar complexity or performance.
Article
Optics
Jiadian Yan, Jun Yao, Yidong Liu, Yuanjie Yang
Summary: Newton's rings are interference patterns consisting of concentric rings, commonly observed in classic optics experiments. In this study, we demonstrate the generation of generalized Newton's rings using vortex beams. Unlike conventional Newton's rings, the generalized ones exhibit spiral arms instead of concentric rings, accompanied by fork-shaped dislocations. Notably, the number of spiral arms and dislocations corresponds to the topological charge of the incident vortex beams. Experimental results confirm our theoretical predictions. This novel interference pattern can be utilized for measuring the topological charge of vortex beams.
Article
Andrology
Yanping Huang, Wei Liu, Yidong Liu, Ming Zhang, Xiangguo Lv, Kai Hu, Shiran Xu, Mujun Lu
Summary: Glycated serum albumin (GSA) decreases the expression of phosphorylated connexin 43 (p-Cx43) in the corpus cavernosum of rats. This effect might be related to the decreased phosphorylation of p-eNOS, p-PI3K, and p-Akt, as well as the downregulation of phosphorylation at the S368 site.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2022)
Article
Surgery
Chengjiang Liu, Yidong Liu, Boyuan Ma, Mengmeng Zhou, Xinyan Zhao, Xuanhao Fu, Shunli Kan, Wei Hu, Rusen Zhu
Summary: Anterior cervical discectomy and fusion (ACDF) is a common surgery for cervical diseases, with low infection rates and rare involvement of adjacent segments. Tuberculosis (TB) is a common infectious disease that rarely affects the cervical spine. Here, we report a case of tuberculosis infection in adjacent segments after ACDF for the first time.
FRONTIERS IN SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Yunzhe Jiang, Yidong Liu, Sylvain Grosjean, Volodymyr Bon, Patrick Hodapp, Anemar Bruno Kanj, Stefan Kaskel, Stefan Braese, Christof Woell, Lars Heinke
Summary: In this research, we achieved a directed responsive behavior of light-induced deformation by assembling light-powered molecules into a surface-mounted metal-organic framework film. The molecular extension changes were multiplied at the mesoscopic scale and transferred to the macroscopic scale, resulting in the bending of a cantilever and performing work.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Electrical & Electronic
Liu Yidong, Jia Zhentang
Summary: The article describes an improved particle swarm optimization camera parameter calibration method that dynamically adjusts the inertia weight of the group and adapts the optimal particle variation to improve calibration accuracy and search ability. Experimental results show that the algorithm has advantages.
LASER & OPTOELECTRONICS PROGRESS
(2022)
Review
Medicine, General & Internal
Chengjiang Liu, Yidong Liu, Boyuan Ma, Mengmeng Zhou, Xinyan Zhao, Xuanhao Fu, Shunli Kan, Wei Hu, Rusen Zhu
Summary: Spinal cord injury is a severe injury to the central nervous system, resulting in permanent loss of motor, sensory, and autonomic functions below the level of injury. Secondary injury impairs mitochondrial function and exacerbates the damage. Therapeutic strategies aimed at preserving mitochondrial function show promise but are still underexplored.
Article
Clinical Neurology
Hu Wei, Kan Shunli, Jiang Zehua, Zhang Tengfei, Liu Yidong, Zhu Rusen
Summary: This study retrospectively analyzed 8 cases of ASD cervical spondylopathy treated with ACCF, and showed significant improvements in clinical outcomes with the use of self-locking stand-alone cage. The method was considered reliable and effective in terms of JOA and NDI scores, as well as cervical alignment correction.
TURKISH NEUROSURGERY
(2021)