Article
Plant Sciences
Si Chen, Yan Lu, Yue Chen, Jindi Xu, Lulu Chen, Weibo Zhao, Tingting Wang, Hui Wang, Peijuan Wang
Summary: BSHXT, a traditional Chinese medicine formula, has shown therapeutic effects on autoimmune premature ovarian insufficiency in mice by enhancing antioxidant capacity and activating the Nrf2/Keap1 signaling pathway, making it a potential candidate for clinical use as a protective agent for POI.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yonghui Hou, Dan Luo, Yu Hou, Jiyao Luan, Jiheng Zhan, Zepeng Chen, E. Shunmei, Liangliang Xu, Dingkun Lin
Summary: In this study, we determined the main chemical constituents of Bu-Shen-Huo-Xue (BSHX) decoction and investigated its effects and underlying mechanisms in spinal cord injury (SCI) recovery. The results showed that BSHX decoction improved the pathological findings in SCI mice and promoted axonal regeneration and functional recovery. These findings suggest that BSHX treatment could be a potential therapeutic approach for SCI.
Article
Chemistry, Analytical
Linghui Li, Xu Wei, Kaiming Li, Hao Gong, Liguo Zhu, Shaofeng Yang, Shangquan Wang, Jinyu Gu, Ming Chen, Xunlu Yin, Jiawen Zhan, Minshan Feng, Jie Yu, Wu Sun, Xin Chen
Summary: The study found that the traditional Chinese medicine decoction, Bu-Shen-Huo-Xue-Fang (BSHXF), can improve intervertebral disc degeneration. The active ingredients Aucubin and Tanshinol promote cell viability, increase extracellular matrix deposition, and inhibit cell senescence, possibly through the NF-cB and Wnt signaling pathways.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Haibo Hu, Fengchan Wang, Ping Han, Peng Li, Kun Wang, Huan Song, Guojing Zhao, Yue Li, Xuechao Lu, Weihong Tao, Huantian Cui
Summary: In this study, it was found that the traditional Chinese medicine Bu-Fei-Huo-Xue capsule had significant therapeutic effects on pulmonary fibrosis model mice by improving symptoms and exhibiting anti-inflammatory and anti-oxidative effects. Furthermore, it was observed that Bu-Fei-Huo-Xue capsule modulated the diversity and abundance of gut microbiota, possibly contributing to its therapeutic effects on pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Jialiang Lin, Jionghui Gu, Dongwei Fan, Weishi Li
Summary: This study aims to clarify the potential mechanism of modified Bu-Shen-Huo-Xue decoction (MBSHXD) in treating intervertebral disc degeneration (IDD) using network pharmacology and molecular docking methods. The results showed that MBSHXD plays an essential role in regulating inflammation and oxidative stress, and has characteristics of multi-component, multi-target, and multi-pathway in the treatment of IDD. The molecular docking further demonstrated the interactions between the active ingredients of MBSHXD and the core target proteins.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Fangyong Yang, Wenjing Du, Zhao Tang, Ying Wei, Jingcheng Dong
Summary: This study aimed to investigate the therapeutic effect and mechanism of Qing-Re-Huo-Xue formula (QRHXF) on idiopathic pulmonary fibrosis (IPF). The results showed that QRHXF could significantly alleviate the occurrence and development of IPF by inhibiting inflammation and epithelial-mesenchymal transition (EMT). Proteomics analysis revealed that QRHXF intervention could reverse the expression levels of p53 and IGFBP3. Therefore, QRHXF holds promise as a novel treatment strategy for pulmonary fibrosis.
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Jingjing Qin, Tulake Wuniqiemu, Ying Wei, Fangzhou Teng, Jie Cui, Jing Sun, La Yi, Weifeng Tang, Xueyi Zhu, Weifang Xu, Jingcheng Dong
Summary: This study evaluated the therapeutic efficacy of JWBSYQF in an asthma mouse model and identified the targeted proteins and functional pathways associated with its treatment.
Review
Immunology
A. Yeong Lee, Taehee Kim, Jong Hoon Kim
Summary: Autoimmune bullous diseases (AIBDs) are life-threatening blistering diseases caused by autoantibodies targeting skin proteins. CD4(+) T cells play a critical role in the production of pathogenic autoantibodies in AIBDs. Understanding the pathogenicity and immune tolerance mechanisms of CD4(+) T cells could lead to improved treatment of AIBDs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Achilleas Floudas, Nuno Neto, Carl Orr, Mary Canavan, Phil Gallagher, Conor Hurson, Michael G. Monaghan, Sunil Nagpar, Ronan H. Mullan, Douglas J. Veale, Ursula Fearon
Summary: This study investigates pathogenic and protective polyfunctional T-cell responses in patients with rheumatoid arthritis (RA), individuals at risk (IAR), and healthy controls (HC) synovial tissue biopsies, identifying a novel population of pathogenic polyfunctional T-cells enriched in RA joints prior to clinical inflammation. Results show increased plasticity of Tfh cells and CD4 T-cell polyfunctionality in RA patients, with enrichment of memory Treg cell responses. The switch from potentially protective to pathogenic T-cell polyfunctionality prior to clinical inflammation highlights a potential therapeutic intervention opportunity in RA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
David Martinez-Mendez, Luis Mendoza, Carlos Villarreal, Leonor Huerta
Summary: During the activation of T CD4+ cells, the balance between oxidative phosphorylation and glycolysis is regulated by the nutrient sensor adenosine monophosphate-activated protein kinase (AMPK), which plays a crucial role in cell metabolism regulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Alyxzandria M. Gaydosik, Tracy Tabib, Robyn Domsic, Dinesh Khanna, Robert Lafyatis, Patrizia Fuschiotti
Summary: Through single-cell transcriptome analysis, different subsets of T cells in healthy and SSc skin were identified, each associated with distinct signaling pathways. A unique subset of recirculating CXCL13(+) T cells in SSc skin was discovered, expressing a T helper follicular-like gene expression signature and potentially promoting B-cell responses in the inflamed skin of patients.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Clinical Neurology
Nail Benallegue, Hania Kebir, Richa Kapoor, Alexis Crockett, Cen Li, Lara Cheslow, Mohamed S. Abdel-Hakeem, James Gesualdi, Miles C. Miller, E. John Wherry, Molly E. Church, M. Andres Blanco, Jorge Alvarez
Summary: The study reveals the previously unrecognized role of the endogenous hedgehog signaling pathway in regulating pathogenic inflammation within the central nervous system. By targeting CD4 T cells and modulating the production of inflammatory cytokines, the hedgehog pathway shows potential as a therapeutic strategy to limit the progression of ongoing neuroinflammation. Systemic administration of a hedgehog agonist after disease onset effectively halts disease progression and reduces neuroinflammation and associated neuropathology.
Article
Medicine, Research & Experimental
Ji-Qiao Zhu, Jing Wang, Xian-Liang Li, Wen-Li Xu, Shao-cheng Lv, Xin Zhao, Ren Lang, Qiang He
Summary: During acute hepatic rejection, the expression of TGF-beta and granzyme B in CD19(+)B cells, and the expression of IL-2 and IFN-gamma in CD4(+)T cells were elevated. A combination of the percentages of IFN-gamma(+)CD4(+)T cells and granzyme B(+)CD19(+)B cells can distinguish rejection from non-rejection, serving as a potential prognostic marker for acute rejection in liver transplant recipients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Fabienne Mazerolles, Frederic Rieux-Laucat
Summary: The expression of co-signalling receptors on T cells plays a crucial role in regulating T cell responses, and an imbalance between activating and inhibitory signals may lead to autoimmunity. Research showed that activated TEFFs and TREGs express different co-signalling receptors, and the expression of PD-L1 on activated TEFFs is correlated with their proliferation.