Diagnosis and treatment of cardiac iron overload in transfusion-dependent thalassemia patients

Combined iron chelator and T-type calcium channel blocker exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice

(2018) Sirinart Kumfu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy

(2018) Natthaphat Siri-Angkul et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A randomized, controlled study evaluating effects of amlodipine addition to chelators to reduce iron loading in patients with thalassemia major

(2017) Aziz Eghbali et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

A combination of an iron chelator with an antioxidant exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice

(2017) Sirinart Kumfu et al.   FREE RADICAL RESEARCH

Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine

(2017) Suwakon Wongjaikam et al.   Scientific Reports

Management of iron overload before, during, and after hematopoietic stem cell transplantation for thalassemia major

(2016) Emanuele Angelucci et al.   Annals of the New York Academy of Sciences

A randomized trial of amlodipine in addition to standard chelation therapy in patients with thalassemia major

(2016) J. L. Fernandes et al.   BLOOD

Minihepcidin peptides as disease modifiers in mice affected by  -thalassemia and polycythemia vera

(2016) C. Casu et al.   BLOOD

Dual T-type and L-type calcium channel blocker exerts beneficial effects in attenuating cardiovascular dysfunction in iron-overloaded thalassaemic mice

(2016) Sirinart Kumfu et al.   EXPERIMENTAL PHYSIOLOGY

Combined Iron Chelator and Antioxidant Exerted Greater Efficacy on Cardioprotection Than Monotherapy in Iron-Overloaded Rats

(2016) Suwakon Wongjaikam et al.   PLoS One

Heart Rate Variability for Early Detection of Cardiac Iron Deposition in Patients with Transfusion-Dependent Thalassemia

(2016) Suchaya Silvilairat et al.   PLoS One

Current and future treatment strategies for iron overload cardiomyopathy

(2015) Suwakon Wongjaikam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cardiomyopathy Associated with Iron Overload: How Does Iron Enter Myocytes and What are the Implications for Pharmacological Therapy?

(2015) Karn Wijarnpreecha et al.   HEMOGLOBIN

Heart Rate Variability for Early Detection of Iron Overload Cardiomyopathy inβ-Thalassemia Patients

(2015) Nut Koonrungsesomboon et al.   HEMOGLOBIN

Treatment ofβ-Thalassemia/Hemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State

(2015) Orn-uma Yanpanitch et al.   Oxidative Medicine and Cellular Longevity

Heart Rate Variability as an Alternative Indicator for Identifying Cardiac Iron Status in Non-Transfusion Dependent Thalassemia Patients

(2015) Karn Wijarnpreecha et al.   PLoS One

A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in  -thalassemia major (CORDELIA)

(2014) D. J. Pennell et al.   BLOOD

N-Acetylcysteine Supplementation Reduces Oxidative Stress and DNA Damage in Children with β-Thalassemia

(2014) Zeynep Canan Ozdemir et al.   HEMOGLOBIN

The α-Thalassemias

(2014) Frédéric B. Piel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of L-type calcium channel blocker (amlodipine) on myocardial iron deposition in patients with thalassaemia with moderate-to-severe myocardial iron deposition: protocol for a randomised, controlled trial

(2014) Amarah Shakoor et al.   BMJ Open

Amlodipine Reduces Cardiac Iron Overload in Patients with Thalassemia Major: A Pilot Trial

(2013) Juliano Lara Fernandes et al.   AMERICAN JOURNAL OF MEDICINE

Cardiovascular Function and Treatment in β-Thalassemia Major

(2013) Dudley J. Pennell et al.   CIRCULATION

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

(2013) Shuling Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Salvia miltiorrhiza (Danshen) Injection Ameliorates Iron Overload-Induced Cardiac Damage in Mice

(2013) Jian-ping Zhang et al.   PLANTA MEDICA

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine  -thalassemia intermedia

(2012) P. J. Schmidt et al.   BLOOD

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of  -thalassemia

(2012) A. Nai et al.   BLOOD

Combined chelation therapy with deferasirox and deferoxamine in thalassemia

(2012) Ashutosh Lal et al.   BLOOD CELLS MOLECULES AND DISEASES

T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice

(2012) Sirinart Kumfu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Deferasirox for up to 3 years leads to continued improvement of myocardial T2* in patients with  -thalassemia major

(2012) D. J. Pennell et al.   HAEMATOLOGICA

Iron Overload in Human Disease

(2012) Robert E. Fleming et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assessment of Cardiac Parameters in Evaluation of Cardiac Functions in Patients with Thalassemia Major

(2012) Kazim Oztarhan et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Successful chelation therapy with the combination of deferasirox and deferiprone in a patient with thalassaemia major and persisting severe iron overload after single-agent chelation therapies

(2011) Ersi Voskaridou et al.   BRITISH JOURNAL OF HAEMATOLOGY

Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity

(2011) Suree Lekawanvijit et al.   CANADIAN JOURNAL OF CARDIOLOGY

On T2* Magnetic Resonance and Cardiac Iron

(2011) John-Paul Carpenter et al.   CIRCULATION

Response of iron overload to deferasirox in rare transfusion-dependent anaemias: equivalent effects on serum ferritin and labile plasma iron for haemolytic or production anaemias

(2011) John B. Porter et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Lipocalin-2 Induces Cardiomyocyte Apoptosis by Increasing Intracellular Iron Accumulation

(2011) Guoxiong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron-Chelating Therapy for Transfusional Iron Overload

(2011) Gary M. Brittenham   NEW ENGLAND JOURNAL OF MEDICINE

Combining two orally active iron chelators for thalassemia

(2010) Vasilios Berdoukas et al.   ANNALS OF HEMATOLOGY

The inherited diseases of hemoglobin are an emerging global health burden

(2010) D. J. Weatherall   BLOOD

β-Thalassemia Cardiomyopathy

(2010) Dimitrios T. Kremastinos et al.   Circulation-Heart Failure

Myocardial iron grading by endomyocardial biopsy. A clinico-pathologic study on iron overloaded patients

(2010) Giovanni Barosi et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice

(2010) Sirinart Kumfu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Guideline recommendations for heart complications in thalassemia major

(2010) Tiziana Cogliandro et al.   Journal of Cardiovascular Medicine

Preferential patterns of myocardial iron overload by multislice multiecho T*2 CMR in thalassemia major patients

(2010) Antonella Meloni et al.   MAGNETIC RESONANCE IN MEDICINE

Reversal of Cardiac Iron Loading and Dysfunction in Thalassemic Mice by Curcuminoids

(2010) C. Thephinlap et al.   Medicinal Chemistry

Interdependence of cardiac iron and calcium in a murine model of iron overload

(2010) Maya Otto-Duessel et al.   Translational Research

Efficacy of deferasirox in reducing and preventing cardiac iron overload in  -thalassemia

(2009) D. J. Pennell et al.   BLOOD

Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury

(2009) T. V. Adamkiewicz et al.   BLOOD

Daily labile plasma iron as an indicator of chelator activity inThalassaemia majorpatients

(2009) Giuliana Zanninelli et al.   BRITISH JOURNAL OF HAEMATOLOGY

Heart rate variability in beta-thalassemia patients

(2009) Wasarut Rutjanaprom et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

High nontransferrin bound iron levels and heart disease in thalassemia major

(2008) Antonio Piga et al.   AMERICAN JOURNAL OF HEMATOLOGY

Longitudinal analysis of heart and liver iron in thalassemia major

(2008) L. J. Noetzli et al.   BLOOD

Global epidemiology of haemoglobin disorders and derived service indicators

(2008) Bernadette Modell   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Molecular Pharmacology of Human Cav3.2 T-Type Ca2+ Channels: Block by Antihypertensives, Antiarrhythmics, and Their Analogs

(2008) E. Perez-Reyes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Heart Rate Variability in Patients with Thalassemia Major

(2008) Firat Kardelen et al.   PEDIATRIC CARDIOLOGY