Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment

Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion

(2017) Jarrett R. Remsberg et al.   Molecular Metabolism

Phenotype and genotype in 52 patients with Rubinstein-Taybi syndrome caused byEP300mutations

(2016) Patricia Fergelot et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The Pentose Phosphate Pathway Regulates the Circadian Clock

(2016) Guillaume Rey et al.   Cell Metabolism

Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice

(2016) Kuntol Rakshit et al.   DIABETOLOGIA

Histone acetylation of glucose-induced thioredoxin-interacting protein gene expression in pancreatic islets

(2016) Pradeep Bompada et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson’s Disease

(2016) Shane V. Hegarty et al.   NEUROTOXICITY RESEARCH

Chromatin Regulators in Pancreas Development and Diabetes

(2016) Stephanie A. Campbell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Computational analyses of type 2 diabetes-associated loci identified by genome-wide association studies

(2016) Mengrong Cheng et al.   Journal of Diabetes

β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1

(2015) Arturo D. Mancini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic mechanisms of melatonin action in human SH-SY5Y neuroblastoma cells

(2015) Yi Pan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of Melatonin Signaling Promotes β-Cell Survival and Function

(2015) Safia Costes et al.   MOLECULAR ENDOCRINOLOGY

Pancreatic   cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

(2015) M. Perelis et al.   SCIENCE

Melatonin and ubiquitin: what’s the connection?

(2014) Jerry Vriend et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Melatonin as a proteasome inhibitor. Is there any clinical evidence?

(2014) Jerry Vriend et al.   LIFE SCIENCES

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

The Melatonin Agonist Ramelteon Induces Duration-Dependent Clock Gene Expression through cAMP Signaling in Pancreatic INS-1 β-Cells

(2014) Keiji Nishiyama et al.   PLoS One

Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells

(2013) Sharona Tornovsky-Babeay et al.   Cell Metabolism

Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders

(2013) Luis Valor et al.   CURRENT PHARMACEUTICAL DESIGN

 -Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?

(2013) S. Costes et al.   DIABETES

Melatonin Secretion and the Incidence of Type 2 Diabetes

(2013) Ciaran J. McMullan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Melatonin prevents pancreaticβ-cell loss due to glucotoxicity: the relationship between oxidative stress and endoplasmic reticulum stress

(2013) Jae-Hyung Park et al.   JOURNAL OF PINEAL RESEARCH

Bmal1 and  -Cell Clock Are Required for Adaptation to Circadian Disruption, and Their Loss of Function Leads to Oxidative Stress-Induced  -Cell Failure in Mice

(2013) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets

(2012) Jalal Taneera et al.   Cell Metabolism

Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

(2012) M. Lundh et al.   DIABETOLOGIA

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair

(2012) Qi-En Wang et al.   NUCLEIC ACIDS RESEARCH

Life and death of transcriptional co-activator p300

(2011) Jihong Chen et al.   Epigenetics

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

(2010) J F Rivera et al.   CELL DEATH AND DIFFERENTIATION

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

(2010) Erin M. Bowers et al.   CHEMISTRY & BIOLOGY

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes

(2009) Charlotte Ling et al.   DIABETES

Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose

(2009) Eckhard Mühlbauer et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucose-stimulated Expression of Txnip Is Mediated by Carbohydrate Response Element-binding Protein, p300, and Histone H4 Acetylation in Pancreatic Beta Cells

(2009) Hyunjoo Cha-Molstad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MODY7Gene,KLF11, Is a Novel p300-dependent Regulator ofPdx-1(MODY4) Transcription in Pancreatic Islet β Cells

(2009) Martin E. Fernandez-Zapico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Arrestin 1 Is Required for PAC1Receptor-mediated Potentiation of Long-lasting ERK1/2 Activation by Glucose in Pancreatic β-Cells

(2008) Christophe Broca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Role for the Pineal and Melatonin in Glucose Homeostasis: Pinealectomy Increases Night-Time Glucose Concentrations

(2003) S. E. La Fleur et al.   JOURNAL OF NEUROENDOCRINOLOGY