The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG

Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression

(2018) Noah Isakov   SEMINARS IN CANCER BIOLOGY

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

(2016) Daniel Martinez Molina et al.   Annual Review of Pharmacology and Toxicology

Oxymatrine synergistically enhances antitumor activity of oxaliplatin in colon carcinoma through PI3K/AKT/mTOR pathway

(2016) Yan Liu et al.   APOPTOSIS

Sinularin Induces Apoptosis through Mitochondria Dysfunction and Inactivation of the pI3K/Akt/mTOR Pathway in Gastric Carcinoma Cells

(2016) Yu-Jen Wu et al.   Marine Drugs

Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo

(2016) Chin-Cheng Su et al.   ONCOLOGY REPORTS

Small Molecule APY606 Displays Extensive Antitumor Activity in Pancreatic Cancer via Impairing Ras-MAPK Signaling

(2016) Na Guo et al.   PLoS One

Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C

(2016) Suthakar Ganapathy et al.   Oncotarget

Upstream and Downstream Co-inhibition of Mitogen-Activated Protein Kinase and PI3K/Akt/mTOR Pathways in Pancreatic Ductal Adenocarcinoma

(2016) Matthew H. Wong et al.   NEOPLASIA

Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer

(2015) Radha Munagala et al.   CANCER LETTERS

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells

(2015) Dan Zi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteomics Analysis of Cellular Proteins Co-Immunoprecipitated with Nucleoprotein of Influenza A Virus (H7N9)

(2015) Ningning Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apoptosis and antitumor effects induced by the combination of an mTOR inhibitor and an autophagy inhibitor in human osteosarcoma MG63 cells

(2015) RYOSUKE HORIE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A Phase II Open-Label Study of Ganetespib, a Novel Heat Shock Protein 90 Inhibitor for Patients With Metastatic Breast Cancer

(2014) Komal Jhaveri et al.   Clinical Breast Cancer

Potential Therapeutic Roles of Tanshinone IIA in Human Bladder Cancer Cells

(2014) Sheng-Chun Chiu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein kinase C and cancer: what we know and what we do not

(2013) R Garg et al.   ONCOGENE

Tanshinone IIA inhibits human prostate cancer cells growth by induction of endoplasmic reticulum stress in vitro and in vivo

(2013) S C Chiu et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Inhibiting HSP90 to Treat Cancer: A Strategy in Evolution

(2012) L. Whitesell et al.   CURRENT MOLECULAR MEDICINE

Applications of Connectivity Map in drug discovery and development

(2012) Xiaoyan A. Qu et al.   DRUG DISCOVERY TODAY

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab

(2011) S. Modi et al.   CLINICAL CANCER RESEARCH

Contribution of individual PKC isoforms to breast cancer progression

(2011) Alejandro J. Urtreger et al.   IUBMB LIFE

Fine Tuning of Protein Kinase C (PKC) Isoforms in Cancer: Shortening the Distance from the Laboratory to the Bedside

(2011) R. Bosco et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map

(2011) Zhining Wen et al.   PLoS One

Tanshinone IIA Induces Mitochondria Dependent Apoptosis in Prostate Cancer Cells in Association with an Inhibition of Phosphoinositide 3-Kinase/AKT Pathway

(2010) Suk-Hyun Won et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

PKCα expression is a marker for breast cancer aggressiveness

(2010) Gry Lønne et al.   Molecular Cancer

Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells

(2009) Yun-feng Shan et al.   ACTA PHARMACOLOGICA SINICA

Roles of PKC isoforms in the induction of apoptosis elicited by aberrant Ras

(2009) T Zhu et al.   ONCOGENE

Natural compounds for cancer treatment and prevention

(2009) Stefania Nobili et al.   PHARMACOLOGICAL RESEARCH