PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway

(2016) Naihua Liu et al.   CANCER LETTERS

The safety of phosphodiesterase type 5 inhibitors for erectile dysfunction

(2016) Eugenio Ventimiglia et al.   Expert Opinion On Drug Safety

ALDH1A3, a metabolic target for cancer diagnosis and therapy

(2016) Jiang-Jie Duan et al.   INTERNATIONAL JOURNAL OF CANCER

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

(2016) D. R. Pattabiraman et al.   SCIENCE

Aldehyde dehydrogenase 1A1 in stem cells and cancer

(2016) Hiroyuki Tomita et al.   Oncotarget

Phosphodiesterase Type 5 Inhibitors and Risk of Malignant Melanoma: Matched Cohort Study Using Primary Care Data from the UK Clinical Practice Research Datalink

(2016) Anthony Matthews et al.   PLOS MEDICINE

Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials

(2016) Benjamin Lu et al.   Cancers

Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium

(2016) Greg Finak et al.   Scientific Reports

N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes

(2015) Cynthia A. Morgan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors

(2015) Mauricio Rodriguez-Torres et al.   CLINICAL & EXPERIMENTAL METASTASIS

Identifying and targeting tumor-initiating cells in the treatment of breast cancer

(2015) W. Wei et al.   ENDOCRINE-RELATED CANCER

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer

(2015) Anindita Das et al.   PHARMACOLOGY & THERAPEUTICS

Essential Role of Aldehyde Dehydrogenase 1A3 for the Maintenance of Non-Small Cell Lung Cancer Stem Cells Is Associated with the STAT3 Pathway

(2014) C. Shao et al.   CLINICAL CANCER RESEARCH

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

In Vivo Lymphatic Imaging of a Human Inflammatory Breast Cancer Model

(2014) Germaine D. Agollah et al.   Journal of Cancer

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Sulindac Selectively Inhibits Colon Tumor Cell Growth by Activating the cGMP/PKG Pathway to Suppress Wnt/ -Catenin Signaling

(2013) N. Li et al.   MOLECULAR CANCER THERAPEUTICS

Aldehyde Dehydrogenase 1 Identifies Cells with Cancer Stem Cell-Like Properties in a Human Renal Cell Carcinoma Cell Line

(2013) Kosuke Ueda et al.   PLoS One

High Expression of CD109 Antigen Regulates the Phenotype of Cancer Stem-Like Cells/Cancer-Initiating Cells in the Novel Epithelioid Sarcoma Cell Line ESX and Is Related to Poor Prognosis of Soft Tissue Sarcoma

(2013) Makoto Emori et al.   PLoS One

Repurposing phosphodiesterase-5 inhibitors as chemoadjuvants

(2013) Amit K. Tiwari et al.   Frontiers in Pharmacology

Aldehyde dehydrogenase 1A1 confers intrinsic and acquired resistance to gemcitabine in human pancreatic adenocarcinoma MIA PaCa-2 cells

(2012) HONG-QUAN DUONG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation

(2012) S M Kumar et al.   ONCOGENE

Expression of aldehyde dehydrogenase 1 (ALDH1) in endometrioid adenocarcinoma and its clinical implications

(2011) Nur Rahadiani et al.   CANCER SCIENCE

Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab

(2011) Lori S. Hart et al.   CELL CYCLE

Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity and outcome to neoadjuvant chemotherapy

(2011) Thaer Khoury et al.   MODERN PATHOLOGY

NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation

(2011) C R Jeter et al.   ONCOGENE

Colon Tumor Cell Growth-Inhibitory Activity of Sulindac Sulfide and Other Nonsteroidal Anti-Inflammatory Drugs Is Associated with Phosphodiesterase 5 Inhibition

(2010) H. N. Tinsley et al.   Cancer Prevention Research

Aldehyde Dehydrogenase Activity Selects for Lung Adenocarcinoma Stem Cells Dependent on Notch Signaling

(2010) J. P. Sullivan et al.   CANCER RESEARCH

Molecular biology of breast cancer stem cells: Potential clinical applications

(2010) Nam P. Nguyen et al.   CANCER TREATMENT REVIEWS

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer

(2009) E. Charafe-Jauffret et al.   CLINICAL CANCER RESEARCH

High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability

(2008) Alysha K. Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE