HMGA1 exacerbates tumor growth through regulating the cell cycle and accelerates migration/invasion via targeting miR-221/222 in cervical cancer

Downregulation of miR-221 enhances the sensitivity of human oral squamous cell carcinoma cells to Adriamycin through upregulation of TIMP3 expression

(2016) Dan Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells

(2016) Karthik Subramanian Chandrasekaran et al.   BRITISH JOURNAL OF CANCER

The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development

(2016) T.F. Sumter et al.   CURRENT MOLECULAR MEDICINE

The High Mobility Group A1 ( HMGA1 ) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 ( MMP-2 ) in a subset of tumors

(2016) Joelle Hillion et al.   GYNECOLOGIC ONCOLOGY

A network-biology perspective of microRNA function and dysfunction in cancer

(2016) Cameron P. Bracken et al.   NATURE REVIEWS GENETICS

The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA Repair

(2016) Ilenia Pellarin et al.   PLoS One

Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis

(2016) Ryosuke Fujikane et al.   Scientific Reports

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Overexpression of HMGA1 correlates with the malignant status and prognosis of breast cancer

(2015) Ruixue Huang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Role of MicroRNAs-221/222 in Digestive Systems

(2015) Juntaro Matsuzaki et al.   Journal of Clinical Medicine

HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness

(2015) Silvia Pegoraro et al.   Oncotarget

HMGA1 silencing restores normal stem cell characteristics in colon cancer stem cells by increasing p53 levels

(2015) Francesca Puca et al.   Oncotarget

Human Papilloma Virus-Dependent HMGA1 Expression Is a Relevant Step in Cervical Carcinogenesis

(2015) Massimiliano Mellone et al.   NEOPLASIA

The high mobility group A1 molecular switch: turning on cancer – can we turn it off?

(2014) Tait H Huso et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Identification and consequences of miRNA–target interactions — beyond repression of gene expression

(2014) Jean Hausser et al.   NATURE REVIEWS GENETICS

Knockdown of HMGA1 inhibits human breast cancer cell growth and metastasis in immunodeficient mice

(2013) Francescopaolo Di Cello et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis

(2013) YUSUKE TAKAHASHI et al.   ONCOLOGY REPORTS

miR-29b, miR-205 and miR-221 Enhance Chemosensitivity to Gemcitabine in HuH28 Human Cholangiocarcinoma Cells

(2013) Kinya Okamoto et al.   PLoS One

Caveolin-1 Increases Aerobic Glycolysis in Colorectal Cancers by Stimulating HMGA1-MediatedGLUT3Transcription

(2012) Tae-Kyu Ha et al.   CANCER RESEARCH

MicroRNA-137, an HMGA1 Target, Suppresses Colorectal Cancer Cell Invasion and Metastasis in Mice by Directly Targeting FMNL2

(2012) Li Liang et al.   GASTROENTEROLOGY

HPV: The global burden

(2012) James Mitchell Crow   NATURE

HMGA1 Induces Intestinal Polyposis in Transgenic Mice and Drives Tumor Progression and Stem Cell Properties in Colon Cancer Cells

(2012) Amy Belton et al.   PLoS One

High-mobility group A1 protein inhibits p53-mediated intrinsic apoptosis by interacting with Bcl-2 at mitochondria

(2012) F Esposito et al.   Cell Death & Disease

HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis

(2011) Andrew Schuldenfrei et al.   BMC GENOMICS

miR221/222 in Cancer: Their Role in Tumor Progression and Response to Therapy

(2011) M. Garofalo et al.   CURRENT MOLECULAR MEDICINE

HMGA1 expression in human gliomas and its correlation with tumor proliferation, invasion and angiogenesis

(2011) Bo Pang et al.   JOURNAL OF NEURO-ONCOLOGY

High-mobility group A1 proteins enhance the expression of the oncogenic miR-222 in lung cancer cells

(2011) Yunzhi Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cis -regulation of microRNA expression by scaffold/matrix-attachment regions

(2011) Pavithra Lakshminarasimhan Chavali et al.   NUCLEIC ACIDS RESEARCH

The High Mobility Group A1 Gene: Transforming Inflammatory Signals into Cancer?

(2010) L. M.S. Resar   CANCER RESEARCH

High-Mobility Group A1 Proteins Regulate p53-Mediated Transcription of Bcl-2 Gene

(2010) F. Esposito et al.   CANCER RESEARCH

Role of the high mobility group A proteins in the regulation of pituitary cell cycle

(2010) Monica Fedele et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

MicroRNA Cluster 221-222 and Estrogen Receptor α Interactions in Breast Cancer

(2010) Gianpiero Di Leva et al.   JNCI-Journal of the National Cancer Institute

miR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation

(2009) Michela Garofalo et al.   CANCER CELL

HMGA1 Levels Influence Mitochondrial Function and Mitochondrial DNA Repair Efficiency

(2009) L. Mao et al.   MOLECULAR AND CELLULAR BIOLOGY

Upregulation of MMP-2 by HMGA1 Promotes Transformation in Undifferentiated, Large-Cell Lung Cancer

(2009) J. Hillion et al.   MOLECULAR CANCER RESEARCH

HMGA1 Is a Molecular Determinant of Chemoresistance to Gemcitabine in Pancreatic Adenocarcinoma

(2008) S.-S. Liau et al.   CLINICAL CANCER RESEARCH