Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease

IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice

(2016) Yuanyuan Wang et al.   Scientific Reports

Advances in IL-21 biology—enhancing our understanding of human disease

(2015) Stuart G Tangye   CURRENT OPINION IN IMMUNOLOGY

Combined immunodeficiency with CD4 lymphopenia and sclerosing cholangitis caused by a novel loss-of-function mutation affecting IL21R

(2015) B. Erman et al.   HAEMATOLOGICA

Circulating CD4+CXCR5+T Cells Exacerbate B Cell Antibody Production in Crohn's Disease Through IL-21 Secretion

(2015) Zhenlong Wang et al.   IMMUNOLOGICAL INVESTIGATIONS

High-Resolution Gene Expression Profiling Using RNA Sequencing in Patients With Inflammatory Bowel Disease and in Mouse Models of Colitis

(2015) Kristine Holgersen et al.   Journal of Crohns & Colitis

Infliximab Preferentially Induces Clinical Remission and Mucosal Healing in Short Course Crohn’s Disease with Luminal Lesions through Balancing Abnormal Immune Response in Gut Mucosa

(2015) Lijuan Yu et al.   MEDIATORS OF INFLAMMATION

Combined immunodeficiency with CD4 lymphopenia and sclerosing cholangitis caused by a novel loss-of-function mutation affecting IL21R

(2015) B. Erman et al.   HAEMATOLOGICA

IL-21: A Pleiotropic Cytokine with Potential Applications in Oncology

(2015) Michela Croce et al.   Journal of Immunology Research

Biologics in inflammatory bowel disease: what are the data?

(2015) Justin Côté-Daigneault et al.   United European Gastroenterology Journal

Extending the clinical and immunological phenotype of human interleukin-21 receptor deficiency

(2014) P. Stepensky et al.   HAEMATOLOGICA

Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease

(2014) Wenyu Jiang et al.   INFLAMMATION RESEARCH

Predictive validity and immune cell involvement in the pathogenesis of piroxicam-accelerated colitis in interleukin-10 knockout mice

(2014) Kristine Holgersen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Early-onset inflammatory bowel disease and common variable immunodeficiency–like disease caused by IL-21 deficiency

(2014) Elisabeth Salzer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33 promotes GATA-3 polarization of gut-derived T cells in experimental and ulcerative colitis

(2014) Jakob Benedict Seidelin et al.   JOURNAL OF GASTROENTEROLOGY

Interleukin-21 promotes the development of ulcerative colitis and regulates the proliferation and secretion of follicular T helper cells in the colitides microenvironment

(2014) JING YU et al.   Molecular Medicine Reports

Interleukin-21: a double-edged sword with therapeutic potential

(2014) Rosanne Spolski et al.   NATURE REVIEWS DRUG DISCOVERY

Immunopathology of inflammatory bowel disease

(2014) Kori L Wallace   WORLD JOURNAL OF GASTROENTEROLOGY

IL-21 induces IL-22 production in CD4+ T cells

(2014) Ada Yeste et al.   Nature Communications

Anti-tumour necrosis factor therapy enhances mucosal healing through down-regulation of interleukin-21 expression and T helper type 17 cell infiltration in Crohn's disease

(2013) C. Liu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Th17 Cytokines in Inflammatory Bowel Diseases: Discerning the Good from the Bad

(2013) Edoardo Troncone et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Characterisation of enterocolitis in the piroxicam-accelerated interleukin-10 knock out mouse — A model mimicking inflammatory bowel disease

(2013) Kristine Holgersen et al.   Journal of Crohns & Colitis

Increased production of interleukin-21, but not interleukin-17A, in the small intestine characterizes pediatric celiac disease

(2013) M A van Leeuwen et al.   Mucosal Immunology

IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection

(2013) Iwana Schmitz et al.   PLoS Pathogens

TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis

(2012) Mehmet Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

(2012) Katja Lüthje et al.   NATURE IMMUNOLOGY

IL-21 is the primary common   chain-binding cytokine required for human B-cell differentiation in vivo

(2011) M. Recher et al.   BLOOD

Emerging immunological targets in inflammatory bowel disease

(2011) Giovanni Monteleone et al.   CURRENT OPINION IN PHARMACOLOGY

Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease

(2011) Gheorghe Hundorfean et al.   INFLAMMATORY BOWEL DISEASES

Involvement of interleukin-21 in the regulation of colitis-associated colon cancer

(2011) Carmine Stolfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of IL-21 in inflammatory bowel disease

(2010) Francesco Pallone et al.   Expert Review of Clinical Immunology

Characterization of Interleukin-17–Producing Regulatory T Cells in Inflamed Intestinal Mucosa From Patients With Inflammatory Bowel Diseases

(2010) Zaruhi Hovhannisyan et al.   GASTROENTEROLOGY

Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases

(2010) Massimiliano Sarra et al.   INFLAMMATORY BOWEL DISEASES

Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease

(2009) Zhanju Liu et al.   INFLAMMATORY BOWEL DISEASES

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

(2009) Melanie A. Kleinschek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

(2008) Daniele Fina et al.   GASTROENTEROLOGY

Development and characterization of IL-21–producing CD4+T cells

(2008) Akira Suto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 comes of age as a regulator of effector T cells in the gut

(2008) M C Fantini et al.   Mucosal Immunology