Clinically Relevant Plasmid-Host Interactions Indicate that Transcriptional and Not Genomic Modifications Ameliorate Fitness Costs of Klebsiella pneumoniae Carbapenemase-Carrying Plasmids

Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of Bacterial Plasmids Conferring Carbapenem Resistance

(2018) Rebecca A. Weingarten et al.   mBio

Major role of pKpQIL-like plasmids in the early dissemination of KPC-type carbapenemases in the UK

(2017) M. Doumith et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Covert dissemination of carbapenemase-producing Klebsiella pneumoniae (KPC) in a successfully controlled outbreak: long- and short-read whole-genome sequencing demonstrate multiple genetic modes of transmission

(2017) Jessica Martin et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study

(2017) Hajo Grundmann et al.   LANCET INFECTIOUS DISEASES

The evolution of plasmid stability: Are infectious transmission and compensatory evolution competing evolutionary trajectories?

(2017) James P.J. Hall et al.   PLASMID

Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks

(2017) Gustavo C. Cerqueira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistence and reversal of plasmid-mediated antibiotic resistance

(2017) Allison J. Lopatkin et al.   Nature Communications

Compensatory mutations improve general permissiveness to antibiotic resistance plasmids

(2017) Wesley Loftie-Eaton et al.   Nature Ecology & Evolution

Genomic epidemiology of global Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli

(2017) N. Stoesser et al.   Scientific Reports

Horizontal Transfer of Carbapenemase-Encoding Plasmids and Comparison with Hospital Epidemiology Data

(2016) C. A. Hardiman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

KPC enzymes in the UK: an analysis of the first 160 cases outside the North-West region

(2016) Jacqueline Findlay et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Low biological cost of carbapenemase-encoding plasmids following transfer from Klebsiella pneumoniae to Escherichia coli

(2016) Maria Chiara Di Luca et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Characterization of KPC-encoding plasmids from two endemic settings, Greece and Italy

(2016) Costas C. Papagiannitsis et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Comparative effects of overproducing the AraC-type transcriptional regulators MarA, SoxS, RarA and RamA on antimicrobial drug susceptibility inKlebsiella pneumoniae

(2016) Juan-Carlos Jiménez-Castellanos et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Survival and Evolution of a Large Multidrug Resistance Plasmid in New Clinical Bacterial Hosts

(2016) Andreas Porse et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evolved plasmid-host interactions reduce plasmid interference cost

(2016) Hirokazu Yano et al.   MOLECULAR MICROBIOLOGY

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

(2016) Jürgen Brem et al.   Nature Communications

Combined Analysis of Variation in Core, Accessory and Regulatory Genome Regions Provides a Super-Resolution View into the Evolution of Bacterial Populations

(2016) Alan McNally et al.   PLoS Genetics

Carriage of Extended-Spectrum Beta-Lactamase-Plasmids Does Not Reduce Fitness but Enhances Virulence in Some Strains of Pandemic E. coli Lineages

(2016) Katharina Schaufler et al.   Frontiers in Microbiology

Double Copies ofblaKPC-3::Tn4401aon an IncX3 Plasmid in Klebsiella pneumoniae Successful Clone ST512 from Italy

(2015) Daniela Fortini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance

(2015) Johann D. D. Pitout et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Spread of KPC-producing carbapenem-resistant Enterobacteriaceae: the importance of super-spreaders and rectal KPC concentration

(2015) A. Lerner et al.   CLINICAL MICROBIOLOGY AND INFECTION

Microbial Evolution: Towards Resolving the Plasmid Paradox

(2015) R. Craig MacLean et al.   CURRENT BIOLOGY

Parallel Compensatory Evolution Stabilizes Plasmids across the Parasitism-Mutualism Continuum

(2015) Ellie Harrison et al.   CURRENT BIOLOGY

Transcriptome modulations due to A/C2 plasmid acquisition

(2015) Kevin S. Lang et al.   PLASMID

Interactions between horizontally acquired genes create a fitness cost in Pseudomonas aeruginosa

(2015) Alvaro San Millan et al.   Nature Communications

Genomic Analysis of the Emergence and Rapid Global Dissemination of the Clonal Group 258 Klebsiella pneumoniae Pandemic

(2015) Jolene R. Bowers et al.   PLoS One

Comparative Genomic Analysis of KPC-Encoding pKpQIL-Like Plasmids and Their Distribution in New Jersey and New York Hospitals

(2014) L. Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prokka: rapid prokaryotic genome annotation

(2014) T. Seemann   BIOINFORMATICS

Functional genomics to identify the factors contributing to successful persistence and global spread of an antibiotic resistance plasmid

(2014) Jennifer L Cottell et al.   BMC MICROBIOLOGY

Identification of the first imported KPC-3 Klebsiella pneumoniae from the USA to Taiwan

(2014) Hung-Jen Tang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Biofilm formation and susceptibility to gentamicin and colistin of extremely drug-resistant KPC-producing Klebsiella pneumoniae

(2014) Livnat Naparstek et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The EcoKI Type I Restriction-Modification System in Escherichia coli Affects but Is Not an Absolute Barrier for Conjugation

(2014) Louise Roer et al.   JOURNAL OF BACTERIOLOGY

Carbapenem-Resistant Klebsiella pneumoniae Exhibit Variability in Capsular Polysaccharide and Capsule Associated Virulence Traits

(2014) Elizabeth Diago-Navarro et al.   JOURNAL OF INFECTIOUS DISEASES

Bacterial formate hydrogenlyase complex

(2014) J. S. McDowall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive selection and compensatory adaptation interact to stabilize non-transmissible plasmids

(2014) A. San Millan et al.   Nature Communications

Clonality and Resistome Analysis of KPC-ProducingKlebsiella pneumoniaeStrain Isolated in Korea Using Whole Genome Sequencing

(2014) Yangsoon Lee et al.   Biomed Research International

Carbapenemase-producing Klebsiella pneumoniae in the Czech Republic in 2011

(2013) J Hrabák et al.   Eurosurveillance

The impact of the conjugative IncP-1 plasmid pKJK5 on multispecies biofilm formation is dependent on the plasmid host

(2013) Henriette Lyng Røder et al.   FEMS MICROBIOLOGY LETTERS

Positive epistasis between co-infecting plasmids promotes plasmid survival in bacterial populations

(2013) Alvaro San Millan et al.   ISME Journal

Reversion to susceptibility of a carbapenem-resistant clinical isolate of Klebsiella pneumoniae producing KPC-3

(2013) L. Villa et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Inhibition of multidrug efflux as a strategy to prevent biofilm formation

(2013) S. Baugh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Successful control of an outbreak of colonization by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae sequence type 258 in a neonatal intensive care unit, Italy

(2013) M. Giuffrè et al.   JOURNAL OF HOSPITAL INFECTION

Klebsiella pneumoniae ST258 Producing KPC-3 Identified in Italy Carries Novel Plasmids and OmpK36/OmpK35 Porin Variants

(2012) Aurora García-Fernández et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Persistence of Transferable Extended-Spectrum-β-Lactamase Resistance in the Absence of Antibiotic Pressure

(2012) Jennifer L. Cottell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transcriptome Mapping of pAR060302, ablaCMY-2-Positive Broad-Host-Range IncA/C Plasmid

(2012) Kevin S. Lang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Carbapenemases in Klebsiella pneumoniae and Other Enterobacteriaceae: an Evolving Crisis of Global Dimensions

(2012) L. S. Tzouvelekis et al.   CLINICAL MICROBIOLOGY REVIEWS

A Swordless Knight: Epidemiology and Molecular Characteristics of the blaKPC-Negative Sequence Type 258 Klebsiella pneumoniae Clone

(2012) A. Adler et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Plasmid-mediated horizontal gene transfer is a coevolutionary process

(2012) Ellie Harrison et al.   TRENDS IN MICROBIOLOGY

KPC-mediated resistance in Klebsiella pneumoniae in two hospitals in Padua, Italy, June 2009-December 2011: massive spreading of a KPC-3-encoding plasmid and involvement of non-intensive care units

(2012) Sara N Richter et al.   Gut Pathogens

Functional Characterization of Tn4401, a Tn3-Based Transposon Involved inblaKPCGene Mobilization

(2011) Gaelle Cuzon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Characteristics of KPC-Producing Enterobacteriaceae at the Early Stage of Their Dissemination in Poland, 2008–2009

(2011) Anna Baraniak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Country-to-Country Transfer of Patients and the Risk of Multi-Resistant Bacterial Infection

(2011) B. A. Rogers et al.   CLINICAL INFECTIOUS DISEASES

Containment of a Country-wide Outbreak of Carbapenem-Resistant Klebsiella pneumoniae in Israeli Hospitals via a Nationally Implemented Intervention

(2011) M. J. Schwaber et al.   CLINICAL INFECTIOUS DISEASES

Prevalence and Significance of Plasmid Maintenance Functions in the Virulence Plasmids of Pathogenic Bacteria

(2011) Manjistha Sengupta et al.   INFECTION AND IMMUNITY

Containment of an Outbreak of KPC-3-Producing Klebsiella pneumoniae in Italy

(2011) Antonella Agodi et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Emergence of Klebsiella pneumoniae Carbapenemase-Producing Bacteria

(2011) Ryan S. Arnold et al.   SOUTHERN MEDICAL JOURNAL

Complete Nucleotide Sequence of KPC-3-Encoding Plasmid pKpQIL in the Epidemic Klebsiella pneumoniae Sequence Type 258

(2010) A. Leavitt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Bridging cell wall biosynthesis and bacterial morphogenesis

(2010) Pierre-Jean Matteï et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ethanolamine utilization in bacterial pathogens: roles and regulation

(2010) Danielle A. Garsin   NATURE REVIEWS MICROBIOLOGY

Antibiotic resistance and its cost: is it possible to reverse resistance?

(2010) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Isolates in the United States: Clonal Expansion of Multilocus Sequence Type 258

(2009) B. Kitchel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Response of thePseudomonashost chromosomal transcriptome to carriage of the IncP-7 plasmid pCAR1

(2009) Masaki Shintani et al.   ENVIRONMENTAL MICROBIOLOGY

Plasmid pKpQIL encoding KPC-3 and TEM-1 confers carbapenem resistance in an extremely drug-resistant epidemic Klebsiella pneumoniae strain

(2009) A. Leavitt et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

An SOS Inhibitor that Binds to Free RecA Protein: The PsiB Protein

(2009) Vessela Petrova et al.   MOLECULAR CELL

The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro

(2009) Dimitra Serfiotis-Mitsa et al.   NUCLEIC ACIDS RESEARCH

First Report on a Hyperepidemic Clone of KPC-3-Producing Klebsiella pneumoniae in Israel Genetically Related to a Strain Causing Outbreaks in the United States

(2008) S. Navon-Venezia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetic Structures at the Origin of Acquisition of the  -Lactamase blaKPC Gene

(2008) T. Naas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY