Artificial macrocycles as IL-17A/IL-17RA antagonists

A Binding Site on IL-17A for Inhibitory Macrocycles Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

(2016) Alfonso Espada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide

(2016) Shenping Liu et al.   Scientific Reports

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

(2016) Shenping Liu et al.   Scientific Reports

Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials

(2015) Christopher E M Griffiths et al.   LANCET

Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials

(2014) Richard G. Langley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

(2013) Fabrizio Giordanetto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structures of interleukin 17A and its complex with IL-17 receptor A

(2013) Shenping Liu et al.   Nature Communications

Combination of IL-17 and TNFα induces a pro-inflammatory, pro-coagulant and pro-thrombotic phenotype in human endothelial cells

(2012) Arnaud Hot et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential

(2012) Shu Zhu et al.   CLINICAL SCIENCE

Macrocycles in new drug discovery

(2012) Jamie Mallinson et al.   Future Medicinal Chemistry

Rationalizing Tight Ligand Binding through Cooperative Interaction Networks

(2011) Bernd Kuhn et al.   Journal of Chemical Information and Modeling

Structural basis of receptor sharing by interleukin 17 cytokines

(2009) Lauren K Ely et al.   NATURE IMMUNOLOGY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY