Aryl bis-sulfonamides bind to the active site of a homotrimeric isoprenoid biosynthesis enzyme IspF and extract the essential divalent metal cation cofactor

Herbicide discovery in light of rapidly spreading resistance and ever-increasing regulatory hurdles

(2017) Bodo Peters et al.   PEST MANAGEMENT SCIENCE

Unlocking the nucleosome

(2017) Andrew Flaus et al.   SCIENCE

DNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 methylation

(2017) Xiaoyi Wang et al.   SCIENCE

The Methylerythritol Phosphate Pathway to Isoprenoids

(2016) Annika Frank et al.   CHEMICAL REVIEWS

The Halogen Bond

(2016) Gabriella Cavallo et al.   CHEMICAL REVIEWS

The diverse and expanding role of mass spectrometry in structural and molecular biology

(2016) Philip Lössl et al.   EMBO JOURNAL

Native ESI Mass Spectrometry Can Help to Avoid Wrong Interpretations from Isothermal Titration Calorimetry in Difficult Situations

(2016) Philippe Wolff et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Native Mass Spectrometry: What is in the Name?

(2016) Aneika C. Leney et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24

(2016) Shahid Mehmood et al.   Nature Chemistry

Mass Spectrometry of Protein Complexes: From Origins to Applications

(2015) Shahid Mehmood et al.   Annual Review of Physical Chemistry

Aryl Bis-Sulfonamide Inhibitors of IspF fromArabidopsis thalianaandPlasmodium falciparum

(2015) Jonas Thelemann et al.   ChemMedChem

Ferritin family proteins and their use in bionanotechnology

(2015) Didi He et al.   New Biotechnology

A Ligand-observed Mass Spectrometry Approach Integrated into the Fragment Based Lead Discovery Pipeline

(2015) Xin Chen et al.   Scientific Reports

Mass Spectrometry Quantifies Protein Interactions-From Molecular Chaperones to Membrane Porins

(2014) Jonathan T. S. Hopper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic protein ligand interactions - insights from MS

(2014) Carla Schmidt et al.   FEBS Journal

Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC

(2014) Sarah Konzuch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment

(2014) Patrick EF O’Rourke et al.   BMC STRUCTURAL BIOLOGY

Determination of Protein–Ligand Binding Constants of a Cooperatively Regulated Tetrameric Enzyme Using Electrospray Mass Spectrometry

(2013) Dragana Cubrilovic et al.   ACS Chemical Biology

Studying 18 MDa Virus Assemblies with Native Mass Spectrometry

(2013) Joost Snijder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Allosteric mechanisms can be distinguished using structural mass spectrometry

(2013) A. Dyachenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding

(2011) Matthias C. Witschel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Methylerythritol Phosphate (MEP) Pathway for Isoprenoid Biosynthesis as a Target for the Development of New Drugs Against Tuberculosis

(2011) C. Obiol-Pardo et al.   CURRENT MEDICINAL CHEMISTRY

An Electrostatic Charge Partitioning Model for the Dissociation of Protein Complexes in the Gas Phase

(2011) Stephen V. Sciuto et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

(2010) Julie G. Geist et al.   ChemMedChem

Noncovalent Protein Tetramers and Pentamers with “n” Charges Yield Monomers withn/4 andn/5 Charges

(2009) Richard L. Beardsley et al.   ANALYTICAL CHEMISTRY

Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene

(2009) Audrey R. Odom et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Dehydrated but unharmed

(2009) Justin L. P. Benesch et al.   NATURE

Tuberculosis Drug Resistance Mutation Database

(2009) Andreas Sandgren et al.   PLOS MEDICINE

Stability and Shape of Hepatitis B Virus Capsids In Vacuo

(2008) Charlotte Uetrecht et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent

(2008) Puranik Purushottamachar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Extensively drug-resistant tuberculosis: current challenges and threats

(2008) Amita Jain et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Multidrug resistant to extensively drug resistant tuberculosis: What is next?

(2008) Amita Jain et al.   JOURNAL OF BIOSCIENCES

HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures

(2008) Bosco K Ho et al.   BMC STRUCTURAL BIOLOGY