Droplet microfluidics for high-sensitivity and high-throughput detection and screening of disease biomarkers

Accurate Detection of Methicillin-Resistant Staphylococcus aureus in Mixtures by Use of Single-Bacterium Duplex Droplet Digital PCR

(2017) Jun Luo et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A passive microfluidic system based on step emulsification allows the generation of libraries of nanoliter-sized droplets from microliter droplets of varying and known concentrations of a sample

(2017) W. Postek et al.   LAB ON A CHIP

Optimized droplet digital CFU assay (ddCFU) provides precise quantification of bacteria over a dynamic range of 6 logs and beyond

(2017) O. Scheler et al.   LAB ON A CHIP

Passive and active droplet generation with microfluidics: a review

(2017) Pingan Zhu et al.   LAB ON A CHIP

Magnetic digital microfluidics – a review

(2017) Yi Zhang et al.   LAB ON A CHIP

New and developing diagnostic technologies for urinary tract infections

(2017) Michael Davenport et al.   Nature Reviews Urology

Measurement of copy number variation in single cancer cells using rapid-emulsification digital droplet MDA

(2017) Samuel C. Kim et al.   Microsystems & Nanoengineering

Dodecylresorufin (C12R) Outperforms Resorufin in Microdroplet Bacterial Assays

(2016) Ott Scheler et al.   ACS Applied Materials & Interfaces

Evaluation of the performance of quantitative detection of the Listeria monocytogenes prfA locus with droplet digital PCR

(2016) Anna Kristina Witte et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Absolute Quantification of H5-Subtype Avian Influenza Viruses Using Droplet Digital Loop-Mediated Isothermal Amplification

(2016) Yi Hu et al.   ANALYTICAL CHEMISTRY

Single Cell Analysis of Leukocyte Protease Activity Using Integrated Continuous-Flow Microfluidics

(2016) Tengyang Jing et al.   ANALYTICAL CHEMISTRY

Cross-Interface Emulsification for Generating Size-Tunable Droplets

(2016) Peng Xu et al.   ANALYTICAL CHEMISTRY

Single cell multiplexed assay for proteolytic activity using droplet microfluidics

(2016) Ee Xien Ng et al.   BIOSENSORS & BIOELECTRONICS

Use of droplet digital PCR for quantitative and automatic analysis of the HER2 status in breast cancer patients

(2016) Kazutaka Otsuji et al.   BREAST CANCER RESEARCH AND TREATMENT

BRAF Mutation Correlates With High-Risk Langerhans Cell Histiocytosis and Increased Resistance to First-Line Therapy

(2016) Sébastien Héritier et al.   JOURNAL OF CLINICAL ONCOLOGY

Digital microfluidics with a magnetically actuated floating liquid marble

(2016) Mei Kum Khaw et al.   LAB ON A CHIP

Nano-liter droplet libraries from a pipette: step emulsificator that stabilizes droplet volume against variation in flow rate

(2016) Filip Dutka et al.   LAB ON A CHIP

One-step immunoassay of C-reactive protein using droplet microfluidics

(2016) Matthew Y. H. Tang et al.   LAB ON A CHIP

High-throughput screening of antibiotic-resistant bacteria in picodroplets

(2016) X. Liu et al.   LAB ON A CHIP

Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics

(2016) Nachiket Shembekar et al.   LAB ON A CHIP

Multiplex Detection of Rare Mutations by Picoliter Droplet Based Digital PCR: Sensitivity and Specificity Considerations

(2016) Eleonora Zonta et al.   PLoS One

Detection of the T790M mutation of EGFR in plasma of advanced non–small cell lung cancer patients with acquired resistance to tyrosine kinase inhibitors (West Japan oncology group 8014LTR study)

(2016) Takayuki Takahama et al.   Oncotarget

Prospective Validation of Rapid Plasma Genotyping for the Detection ofEGFRandKRASMutations in Advanced Lung Cancer

(2016) Adrian G. Sacher et al.   JAMA Oncology

Digital Droplet Multiple Displacement Amplification (ddMDA) for Whole Genome Sequencing of Limited DNA Samples

(2016) Minsoung Rhee et al.   PLoS One

“V-junction”: a novel structure for high-speed generation of bespoke droplet flows

(2015) Yun Ding et al.   ANALYST

Digital PCR for direct quantification of viruses without DNA extraction

(2015) Jernej Pavšič et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

ddpcRquant: threshold determination for single channel droplet digital PCR experiments

(2015) Wim Trypsteen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Highly Reproducible Absolute Quantification of Mycobacterium tuberculosis Complex by Digital PCR

(2015) Alison S. Devonshire et al.   ANALYTICAL CHEMISTRY

A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening

(2015) Tushar D. Rane et al.   ANALYTICAL CHEMISTRY

Profiling cancer gene mutations in longitudinal epithelial ovarian cancer biopsies by targeted next-generation sequencing: a retrospective study

(2015) L. Beltrame et al.   ANNALS OF ONCOLOGY

Parallelized ultra-high throughput microfluidic emulsifier for multiplex kinetic assays

(2015) Jiseok Lim et al.   Biomicrofluidics

Jetting microfluidics with size-sorting capability for single-cell protease detection

(2015) Tengyang Jing et al.   BIOSENSORS & BIOELECTRONICS

A microfluidic droplet digital PCR for simultaneous detection of pathogenic Escherichia coli O157 and Listeria monocytogenes

(2015) Xiaojun Bian et al.   BIOSENSORS & BIOELECTRONICS

Droplet digital PCR measurement of HER2 in patients with gastric cancer

(2015) H Kinugasa et al.   BRITISH JOURNAL OF CANCER

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Detection of BRAF-V600E and V600K in melanoma circulating tumour cells by droplet digital PCR

(2015) Anna L. Reid et al.   CLINICAL BIOCHEMISTRY

Ultra-Sensitive Detection of the Pretreatment EGFR T790M Mutation in Non-Small Cell Lung Cancer Patients with an EGFR-Activating Mutation Using Droplet Digital PCR

(2015) M. Watanabe et al.   CLINICAL CANCER RESEARCH

Noninvasive Detection of Activating Estrogen Receptor 1 (ESR1) Mutations in Estrogen Receptor-Positive Metastatic Breast Cancer

(2015) D. S. Guttery et al.   CLINICAL CHEMISTRY

The first five years of single-cell cancer genomics and beyond

(2015) Nicholas E. Navin   GENOME RESEARCH

Highly Sensitive Droplet Digital PCR Method for Detection of EGFR-Activating Mutations in Plasma Cell–Free DNA from Patients with Advanced Non–Small Cell Lung Cancer

(2015) Guanshan Zhu et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array

(2015) Ee Xien Ng et al.   LAB ON A CHIP

Optofluidic ultrahigh-throughput detection of fluorescent drops

(2015) Minkyu Kim et al.   LAB ON A CHIP

Centrifugal step emulsification applied for absolute quantification of nucleic acids by digital droplet RPA

(2015) Friedrich Schuler et al.   LAB ON A CHIP

Step-emulsification in a microfluidic device

(2015) Z. Li et al.   LAB ON A CHIP

Microfluidic continuous flow digital loop-mediated isothermal amplification (LAMP)

(2015) Tushar D. Rane et al.   LAB ON A CHIP

The Poisson distribution and beyond: methods for microfluidic droplet production and single cell encapsulation

(2015) David J. Collins et al.   LAB ON A CHIP

EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of leading technologies to support the clinical development of AZD9291

(2015) Kenneth S. Thress et al.   LUNG CANCER

ELISA in the multiplex era: Potentials and pitfalls

(2015) Patrick J. Tighe et al.   Proteomics Clinical Applications

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

(2015) Leticia De Mattos-Arruda et al.   Nature Communications

Droplet Digital Enzyme-Linked Oligonucleotide Hybridization Assay for Absolute RNA Quantification

(2015) Weihua Guan et al.   Scientific Reports

Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations

(2015) Simon Chang-Hao Tsao et al.   Scientific Reports

Enhancing Throughput of Combinatorial Droplet Devices via Droplet Bifurcation, Parallelized Droplet Fusion, and Parallelized Detection

(2015) Kuangwen Hsieh et al.   Micromachines

Recent Advances in Applications of Droplet Microfluidics

(2015) Wei-Lung Chou et al.   Micromachines

Acoustic modulation of droplet size in a T-junction

(2014) Lothar Schmid et al.   APPLIED PHYSICS LETTERS

Noninvasive Detection of Response and Resistance in EGFR-Mutant Lung Cancer Using Quantitative Next-Generation Genotyping of Cell-Free Plasma DNA

(2014) G. R. Oxnard et al.   CLINICAL CANCER RESEARCH

Clinical Relevance of KRAS-Mutated Subclones Detected with Picodroplet Digital PCR in Advanced Colorectal Cancer Treated with Anti-EGFR Therapy

(2014) P. Laurent-Puig et al.   CLINICAL CANCER RESEARCH

Next Generation Digital PCR Measurement of Hepatitis B Virus Copy Number in Formalin-Fixed Paraffin-Embedded Hepatocellular Carcinoma Tissue

(2014) J.-T. Huang et al.   CLINICAL CHEMISTRY

Quantitative Cell-Free Circulating BRAFV600E Mutation Analysis by Use of Droplet Digital PCR in the Follow-up of Patients with Melanoma Being Treated with BRAF Inhibitors

(2014) M. F. Sanmamed et al.   CLINICAL CHEMISTRY

Droplet formation via squeezing mechanism in a microfluidic flow-focusing device

(2014) Amit Gupta et al.   COMPUTERS & FLUIDS

Digital droplet PCR (ddPCR) for the precise quantification of human T-lymphotropic virus 1 proviral loads in peripheral blood and cerebrospinal fluid of HAM/TSP patients and identification of viral mutations

(2014) Giovanna S. Brunetto et al.   JOURNAL OF NEUROVIROLOGY

High-throughput and sensitive next-generation droplet digital PCR assay for the quantitation of the hepatitis C virus mutation at core amino acid 70

(2014) Motokazu Mukaide et al.   JOURNAL OF VIROLOGICAL METHODS

Phase-specific Raman spectroscopy for fast segmented microfluidic flows

(2014) S. K. Luther et al.   LAB ON A CHIP

A biocompatible open-surface droplet manipulation platform for detection of multi-nucleotide polymorphism

(2014) C. J. Huang et al.   LAB ON A CHIP

A droplet-based heterogeneous immunoassay for screening single cells secreting antigen-specific antibodies

(2014) Samin Akbari et al.   LAB ON A CHIP

Microfluidic platforms for biomarker analysis

(2014) Sofia Nahavandi et al.   LAB ON A CHIP

The importance of HIV RNA detection below 50 copies per mL in HIV-positive patients on antiretroviral therapy: an observational study

(2014) Tomas Doyle et al.   LANCET

Microfluidic platforms for discovery and detection of molecular biomarkers

(2014) Lien-Yu Hung et al.   Microfluidics and Nanofluidics

A droplet microfluidic approach to single-stream nucleic acid isolation and mutation detection

(2014) Dong Jin Shin et al.   Microfluidics and Nanofluidics

Review and analysis of performance metrics of droplet microfluidics systems

(2014) Liat Rosenfeld et al.   Microfluidics and Nanofluidics

Comparison of Droplet Digital PCR and Seminested Real-Time PCR for Quantification of Cell-Associated HIV-1 RNA

(2014) Maja Kiselinova et al.   PLoS One

Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection

(2014) Dong-Ku Kang et al.   Nature Communications

Validation of an ultrasensitive digital droplet PCR assay for HIV-2 plasma RNA quantification

(2014) Jean Ruelle et al.   Journal of the International AIDS Society

Ultrarapid Generation of Femtoliter Microfluidic Droplets for Single-Molecule-Counting Immunoassays

(2013) Jung-uk Shim et al.   ACS Nano

Full-Range Magnetic Manipulation of Droplets via Surface Energy Traps Enables Complex Bioassays

(2013) Yi Zhang et al.   ADVANCED MATERIALS

Label-free, high-throughput, electrical detection of cells in droplets

(2013) Evelien W. M. Kemna et al.   ANALYST

Analytical detection techniques for droplet microfluidics—A review

(2013) Ying Zhu et al.   ANALYTICA CHIMICA ACTA

One-step RT-droplet digital PCR: a breakthrough in the quantification of waterborne RNA viruses

(2013) Nejc Rački et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

New Glycosidase Substrates for Droplet-Based Microfluidic Screening

(2013) Majdi Najah et al.   ANALYTICAL CHEMISTRY

Ultrahigh-Throughput Mammalian Single-Cell Reverse-Transcriptase Polymerase Chain Reaction in Microfluidic Drops

(2013) Dennis J. Eastburn et al.   ANALYTICAL CHEMISTRY

Ultra-high throughput detection of single cell β-galactosidase activity in droplets using micro-optical lens array

(2013) Jiseok Lim et al.   APPLIED PHYSICS LETTERS

A droplet-based microfluidic electrochemical sensor using platinum-black microelectrode and its application in high sensitive glucose sensing

(2013) Shuqing Gu et al.   BIOSENSORS & BIOELECTRONICS

Microfluidics and Raman microscopy: current applications and future challenges

(2013) Adam F. Chrimes et al.   CHEMICAL SOCIETY REVIEWS

Droplet Digital PCR Measurement of HER2 Copy Number Alteration in Formalin-Fixed Paraffin-Embedded Breast Carcinoma Tissue

(2013) P. Belgrader et al.   CLINICAL CHEMISTRY

Multiplex Picodroplet Digital PCR to Detect KRAS Mutations in Circulating DNA from the Plasma of Colorectal Cancer Patients

(2013) V. Taly et al.   CLINICAL CHEMISTRY

Detection of Methicillin-Resistant Staphylococcus aureus by a Duplex Droplet Digital PCR Assay

(2013) K. Kelley et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The physical mechanisms of step emulsification

(2013) Rémi Dangla et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Single-enzyme analysis in a droplet-based micro- and nanofluidic system

(2013) Rerngchai Arayanarakool et al.   LAB ON A CHIP

SAW-controlled drop size for flow focusing

(2013) Lothar Schmid et al.   LAB ON A CHIP

Single-cell analysis and sorting using droplet-based microfluidics

(2013) Linas Mazutis et al.   Nature Protocols

Liquid biopsy: monitoring cancer-genetics in the blood

(2013) Emily Crowley et al.   Nature Reviews Clinical Oncology

Highly Precise Measurement of HIV DNA by Droplet Digital PCR

(2013) Matthew C. Strain et al.   PLoS One

Droplet microfluidics driven by gradients of confinement

(2013) R. Dangla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Digital Microfluidics

(2012) Kihwan Choi et al.   Annual Review of Analytical Chemistry

Building droplet-based microfluidic systems for biological analysis

(2012) Xize Niu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Microfluidics and Its Application to Endometriosis

(2012) Chia-Hung Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microfluidic platform for on-demand generation of spatially indexed combinatorial droplets

(2012) Helena Zec et al.   LAB ON A CHIP

Droplet microfluidics for amplification-free genetic detection of single cells

(2012) Tushar D. Rane et al.   LAB ON A CHIP

Droplet Digital™ PCR quantitation of HER2 expression in FFPE breast cancer samples

(2012) Nicholas J. Heredia et al.   METHODS

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Digital PCR hits its stride

(2012) Monya Baker   NATURE METHODS

Monitoring single-cell bioenergetics via the coarsening of emulsion droplets

(2012) L. Boitard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detecting biomarkers with microdroplet technology

(2012) Valérie Taly et al.   TRENDS IN MOLECULAR MEDICINE

Ultrafast Surface Enhanced Resonance Raman Scattering Detection in Droplet-Based Microfluidic Systems

(2011) Michael P. Cecchini et al.   ANALYTICAL CHEMISTRY

Creation of Stepwise Concentration Gradient in Picoliter Droplets for Parallel Reactions of Matrix Metalloproteinase II and IX

(2011) Sachin Jambovane et al.   ANALYTICAL CHEMISTRY

Integrated Glass Microdevice for Nucleic Acid Purification, Loop-Mediated Isothermal Amplification, and Online Detection

(2011) Qingqing Wu et al.   ANALYTICAL CHEMISTRY

High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

(2011) Benjamin J. Hindson et al.   ANALYTICAL CHEMISTRY

Quantitative Characterization of Individual Microdroplets using Surface-Enhanced Resonance Raman Scattering Spectroscopy

(2011) Christopher D. Syme et al.   ANALYTICAL CHEMISTRY

Teaming up for biomarker future

(2011) Andrea Rinaldi   EMBO REPORTS

HIV-1 viral diversity and its implications for viral load testing: review of current platforms

(2011) LeeAnne M. Luft et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Enhancing Protease Activity Assay in Droplet-Based Microfluidics Using a Biomolecule Concentrator

(2011) Chia-Hung Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ELISA and Multiplex Technologies for Cytokine Measurement in Inflammation and Aging Research

(2011) S. X. Leng et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

High-speed droplet generation on demand driven by pulse laser-induced cavitation

(2011) Sung-Yong Park et al.   LAB ON A CHIP

Droplet formation via flow-through microdevices in Raman and surface enhanced Raman spectroscopy—concepts and applications

(2011) Anne März et al.   LAB ON A CHIP

Tunable 3D droplet self-assembly for ultra-high-density digital micro-reactor arrays

(2011) Andrew C. Hatch et al.   LAB ON A CHIP

Multiplex digital PCR: breaking the one target per color barrier of quantitative PCR

(2011) Qun Zhong et al.   LAB ON A CHIP

1-Million droplet array with wide-field fluorescence imaging for digital PCR

(2011) Andrew C. Hatch et al.   LAB ON A CHIP

Quantitative and sensitive detection of rare mutations using droplet-based microfluidics

(2011) Deniz Pekin et al.   LAB ON A CHIP

Emerging molecular biomarkers—blood-based strategies to detect and monitor cancer

(2011) Samir M. Hanash et al.   Nature Reviews Clinical Oncology

Biosensor diagnosis of urinary tract infections: a path to better treatment?

(2011) Kathleen E. Mach et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Single-Cell Multiplex Gene Detection and Sequencing with Microfluidically Generated Agarose Emulsions

(2010) Richard Novak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Valve-based microfluidic device for droplet on-demand operation and static assay

(2010) Feng Guo et al.   APPLIED PHYSICS LETTERS

An all-in-one microfluidic device for parallel DNA extraction and gene analysis

(2010) Yi Zhang et al.   BIOMEDICAL MICRODEVICES

Quantitative Cell-Based Reporter Gene Assays Using Droplet-Based Microfluidics

(2010) Jean-Christophe Baret et al.   CHEMISTRY & BIOLOGY

The Era of Molecular and Other Non-Culture-Based Methods in Diagnosis of Sepsis

(2010) N. Mancini et al.   CLINICAL MICROBIOLOGY REVIEWS

Formation and manipulation of ferrofluid droplets at a microfluidicT-junction

(2010) Say-Hwa Tan et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

Single-sided continuous optoelectrowetting (SCOEW) for droplet manipulation with light patterns

(2010) Sung-Yong Park et al.   LAB ON A CHIP

High-throughput automated droplet microfluidic system for screening of reaction conditions

(2010) Krzysztof Churski et al.   LAB ON A CHIP

A surface topography assisted droplet manipulation platform for biomarker detection and pathogen identification

(2010) Yi Zhang et al.   LAB ON A CHIP

Hysteresis in Multiphase Microfluidics at a T-Junction

(2010) Michele Zagnoni et al.   LANGMUIR

Rapid Molecular Detection of Tuberculosis and Rifampin Resistance

(2010) Catharina C. Boehme et al.   NEW ENGLAND JOURNAL OF MEDICINE

What are biomarkers?

(2010) Kyle Strimbu et al.   Current Opinion in HIV and AIDS

Measuring Rapid Enzymatic Kinetics by Electrochemical Method in Droplet-Based Microfluidic Devices with Pneumatic Valves

(2009) Zuoyan Han et al.   ANALYTICAL CHEMISTRY

Independent Control of Drop Size and Velocity in Microfluidic Flow-Focusing Generators Using Variable Temperature and Flow Rate

(2009) Claudiu A. Stan et al.   ANALYTICAL CHEMISTRY

Droplet-Based Microfluidic Systems for High-Throughput Single DNA Molecule Isothermal Amplification and Analysis

(2009) Linas Mazutis et al.   ANALYTICAL CHEMISTRY

Detection and Analysis of Low-Abundance Cell-Surface Biomarkers Using Enzymatic Amplification in Microfluidic Droplets

(2009) Haakan N. Joensson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibody-Based Protein Multiplex Platforms: Technical and Operational Challenges

(2009) A. A. Ellington et al.   CLINICAL CHEMISTRY

Microvalve-actuated precise control of individual droplets in microfluidic devices

(2009) Shaojiang Zeng et al.   LAB ON A CHIP

Counting single molecules in sub-nanolitre droplets

(2009) T. D. Rane et al.   LAB ON A CHIP

On-Chip Single-Copy Real-Time Reverse-Transcription PCR in Isolated Picoliter Droplets

(2008) N. Reginald Beer et al.   ANALYTICAL CHEMISTRY

A Digital Microfluidic Approach to Homogeneous Enzyme Assays

(2008) Elizabeth M. Miller et al.   ANALYTICAL CHEMISTRY

High-Throughput Quantitative Polymerase Chain Reaction in Picoliter Droplets

(2008) Margaret Macris Kiss et al.   ANALYTICAL CHEMISTRY

Clockwork PCR Including Sample Preparation

(2008) Juergen Pipper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms

(2008) Jenifer Clausell-Tormos et al.   CHEMISTRY & BIOLOGY

Drop on demand in a microfluidic chip

(2008) Jie Xu et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

Drop-based microfluidic devices for encapsulation of single cells

(2008) Sarah Köster et al.   LAB ON A CHIP

Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics

(2008) James Q. Boedicker et al.   LAB ON A CHIP

Reliable microfluidic on-chip incubation of droplets in delay-lines

(2008) Lucas Frenz et al.   LAB ON A CHIP

The cancer biomarker problem

(2008) Charles L. Sawyers   NATURE

Microfluidic large-scale integration on a chip for mass production of monodisperse droplets and particles

(2007) Takasi Nisisako et al.   LAB ON A CHIP