Precision engineering of targeted nanocarriers

Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells

(2017) Lipsa Das et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate

(2017) Tracy S. Zimmermann et al.   MOLECULAR THERAPY

“Silent” Amino Acid Residues at Key Subunit Interfaces Regulate the Geometry of Protein Nanocages

(2016) Shengli Zhang et al.   ACS Nano

Conversion of the Native 24-mer Ferritin Nanocage into Its Non-Native 16-mer Analogue by Insertion of Extra Amino Acid Residues

(2016) Shengli Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Utilizing clathrin triskelions as carriers for spatially controlled multi-protein display

(2016) Michael B. Deci et al.   BIOMATERIALS

A combination of two antibodies recognizing non-overlapping epitopes of HER2 induces kinase activity-dependent internalization of HER2

(2016) Monika Szymanska et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dual CD44 and folate receptor-targeted nanoparticles for cancer diagnosis and anticancer drug delivery

(2016) Jae-Young Lee et al.   JOURNAL OF CONTROLLED RELEASE

A Novel Allosteric Mechanism of NF-κB Dimerization and DNA Binding Targeted by an Anti-Inflammatory Drug

(2016) Shaked Ashkenazi et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation at a distance of biomolecular interactions using a DNA origami nanoactuator

(2016) Yonggang Ke et al.   Nature Communications

Symmetry Controlled, Genetic Presentation of Bioactive Proteins on the P22 Virus-like Particle Using an External Decoration Protein

(2015) Benjamin Schwarz et al.   ACS Nano

Self-Assembly of Ferritin Nanoparticles into an Enzyme Nanocomposite with Tunable Size for Ultrasensitive Immunoassay

(2015) Dong Men et al.   ACS Nano

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

(2015) Edgar Pérez-Herrero et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Integrin traffic - the update

(2015) N. De Franceschi et al.   JOURNAL OF CELL SCIENCE

Targeting Three Distinct HER2 Domains with a Recombinant Antibody Mixture Overcomes Trastuzumab Resistance

(2015) M. W. Pedersen et al.   MOLECULAR CANCER THERAPEUTICS

Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302)

(2015) E. Geretti et al.   MOLECULAR CANCER THERAPEUTICS

Delivery of Lipid Micelles into Infarcted Myocardium Using a Lipid-Linked Matrix Metalloproteinase Targeting Peptide

(2015) Juliane Nguyen et al.   MOLECULAR PHARMACEUTICS

Mechanistic insights into EGFR membrane clustering revealed by super-resolution imaging

(2015) Jing Gao et al.   Nanoscale

Trigonal scaffolds for multivalent targeting of melanocortin receptors

(2015) N. G. R. Dayan Elshan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck

(2015) Kyung-Ho Roh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designing multivalent probes for tunable superselective targeting

(2015) Galina V. Dubacheva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzyme-linked DNA dendrimer nanosensors for acetylcholine

(2015) Ryan Walsh et al.   Scientific Reports

Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer

(2015) Anne-Catherine Lhoumeau et al.   PLoS One

Evaluating Binding Avidities of Populations of Heterogeneous Multivalent Ligand-Functionalized Nanoparticles

(2014) Ming-Hsin Li et al.   ACS Nano

Diversity-Oriented Synthesis of Drug-Like Macrocyclic Scaffolds Using an Orthogonal Organo- and Metal Catalysis Strategy

(2014) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effects of the chemokine CXCL12 and combined internalization of its receptors CXCR4 and CXCR7 in human MCF-7 breast cancer cells

(2014) Kirsten Hattermann et al.   CELL AND TISSUE RESEARCH

Regulation of EGFR nanocluster formation by ionic protein-lipid interaction

(2014) Ye Wang et al.   CELL RESEARCH

Polyvalent Display of Monosaccharides on Ferritin Protein Cage Nanoparticles for the Recognition and Binding of Cell-Surface Lectins

(2014) Young Ji Kang et al.   MACROMOLECULAR BIOSCIENCE

Effect of Receptor Occupancy on Folate Receptor Internalization

(2014) N. Achini Bandara et al.   MOLECULAR PHARMACEUTICS

Spatial control of membrane receptor function using ligand nanocalipers

(2014) Alan Shaw et al.   NATURE METHODS

DENR–MCT1 reinitiates translation

(2014) Eytan Zlotorynski   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A spontaneous penetration mechanism of patterned nanoparticles across a biomembrane

(2014) Ye Li et al.   Soft Matter

Restoring expression of miR-16: a novel approach to therapy for malignant pleural mesothelioma

(2013) G. Reid et al.   ANNALS OF ONCOLOGY

In vivo performance of polymer nanocarriers dually-targeted to epitopes of the same or different receptors

(2013) Iason T. Papademetriou et al.   BIOMATERIALS

Leaving Förster Resonance Energy Transfer Behind: Nanometal Surface Energy Transfer Predicts the Size-Enhanced Energy Coupling between a Metal Nanoparticle and an Emitting Dipole

(2013) Christopher J. Breshike et al.   Journal of Physical Chemistry C

Tuning Polarity of Polyphenylene Dendrimers by Patched Surface Amphiphilicity-Precise Control over Size, Shape, and Polarity

(2013) René Stangenberg et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Measuring EGFR Separations on Cells with ∼10 nm Resolution via Fluorophore Localization Imaging with Photobleaching

(2013) Sarah R. Needham et al.   PLoS One

Spatiotemporal control and superselectivity in supramolecular polymers using multivalency

(2013) L. Albertazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Terminal Labeling of Filamentous Phage To Create Cancer Marker Imaging Agents

(2012) Zachary M. Carrico et al.   ACS Nano

Stoichiometry and Subunit Arrangement of α1β Glycine Receptors As Determined by Atomic Force Microscopy

(2012) Zhe Yang et al.   BIOCHEMISTRY

A versatile coiled-coil tethering system for the oriented display of ligands on nanocarriers for targeted gene delivery

(2012) Charles Fortier et al.   BIOMATERIALS

C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses

(2012) Lara M Kingeter et al.   Cellular & Molecular Immunology

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Limited Transferrin Receptor Clustering Allows Rapid Diffusion of Canine Parvovirus into Clathrin Endocytic Structures

(2012) D. K. Cureton et al.   JOURNAL OF VIROLOGY

Cancer biomarkers

(2012) N. Lynn Henry et al.   Molecular Oncology

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Surface Functionalization of Virus-Like Particles by Direct Conjugation Using Azide−Alkyne Click Chemistry

(2011) Kedar G. Patel et al.   BIOCONJUGATE CHEMISTRY

Complementary targeting of liposomes to IL-1α and TNF-α activated endothelial cells via the transient expression of VCAM1 and E-selectin

(2011) Rico C. Gunawan et al.   BIOMATERIALS

Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells

(2011) N Mazurek et al.   CELL DEATH AND DIFFERENTIATION

Production of Rous sarcoma virus-like particles displaying human transmembrane protein in silkworm larvae and its application to ligand–receptor binding assay

(2011) Yoshitaka Tsuji et al.   JOURNAL OF BIOTECHNOLOGY

Targeted drug delivery to tumors: Myths, reality and possibility

(2011) You Han Bae et al.   JOURNAL OF CONTROLLED RELEASE

Chimeric Ferritin Nanocages for Multiple Function Loading and Multimodal Imaging

(2011) Xin Lin et al.   NANO LETTERS

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers

(2011) Carlee E. Ashley et al.   NATURE MATERIALS

Designing super selectivity in multivalent nano-particle binding

(2011) F. J. Martinez-Veracoechea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein delivery using engineered virus-like particles

(2011) S. J. Kaczmarczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-Clustered “Patchy” Nanoparticles for Modulated Cellular Uptake and In Vivo Tumor Targeting

(2010) Zhiyong Poon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

TRAIL induces endocytosis of its death receptors in MDA-MB-231 breast cancer cells

(2010) Yaqin Zhang et al.   CANCER BIOLOGY & THERAPY

Multivalent Display and Receptor-Mediated Endocytosis of Transferrin on Virus-Like Particles

(2010) Deboshri Banerjee et al.   CHEMBIOCHEM

Gefitinib Targets EGFR Dimerization and ERK1/2 Phosphorylation to Inhibit Pleural Mesothelioma Cell Proliferation

(2010) R. E. Favoni et al.   CURRENT CANCER DRUG TARGETS

Local clustering of transferrin receptors promotes clathrin-coated pit initiation

(2010) Allen P. Liu et al.   JOURNAL OF CELL BIOLOGY

Analysis of Her2/neu membrane protein clusters in different types of breast cancer cells using localization microscopy

(2010) R. KAUFMANN et al.   JOURNAL OF MICROSCOPY

Controlling Ligand Surface Density Optimizes Nanoparticle Binding to ICAM-1

(2010) Amir Fakhari et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Surface Energy Transfer Nanoruler for Measuring Binding Site Distances on Live Cell Surfaces

(2010) Yan Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cryptocaryone, a Natural Dihydrochalcone, Induces Apoptosis in Human Androgen Independent Prostate Cancer Cells by Death Receptor Clustering in Lipid Raft and Nonraft Compartments

(2010) Yi-Cheng Chen et al.   JOURNAL OF UROLOGY

Immunoliposomes That Target Endothelium In Vitro Are Dependent on Lipid Raft Formation

(2010) Rico C. Gunawan et al.   MOLECULAR PHARMACEUTICS

Immobilization and One-Dimensional Arrangement of Virus Capsids with Nanoscale Precision Using DNA Origami

(2010) Nicholas Stephanopoulos et al.   NANO LETTERS

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

(2010) J. B. Spangler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Assembly of Hybrid Bacteriophage Qβ Virus-like Particles

(2009) Steven D. Brown et al.   BIOCHEMISTRY

The role of antibody synergy and membrane fluidity in the vascular targeting of immunoliposomes

(2009) Rico C. Gunawan et al.   BIOMATERIALS

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ligand-independent higher-order multimerization of CXCR4, a G-protein-coupled chemokine receptor involved in targeted metastasis

(2009) Makiko Hamatake et al.   CANCER SCIENCE

VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

(2009) Marja Lohela et al.   CURRENT OPINION IN CELL BIOLOGY

Oxaliplatin enhances TRAIL-induced apoptosis in gastric cancer cells by CBL-regulated death receptor redistribution in lipid rafts

(2009) Ling Xu et al.   FEBS LETTERS

JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling

(2009) M. R. Cera et al.   JOURNAL OF CELL SCIENCE

Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth

(2009) Neelesh R. Soman et al.   JOURNAL OF CLINICAL INVESTIGATION

Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles

(2009) Gary J. Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoscale Protein Assemblies from a Circular Permutant of the Tobacco Mosaic Virus

(2009) Michel T. Dedeo et al.   NANO LETTERS

Lipid Raft-Mediated Regulation of G-Protein Coupled Receptor Signaling by Ligands which Influence Receptor Dimerization: A Computational Study

(2009) Mohammad Fallahi-Sichani et al.   PLoS One

Persistent elimination of ErbB-2/HER2-overexpressing tumors using combinations of monoclonal antibodies: Relevance of receptor endocytosis

(2009) T. Ben-Kasus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of G-proteins in the dimerisation of human somatostatin receptor types 2 and 5

(2009) Michael Grant et al.   REGULATORY PEPTIDES

Magnetic nanoparticles in MR imaging and drug delivery☆

(2008) C SUN et al.   ADVANCED DRUG DELIVERY REVIEWS

Unnatural Amino Acid Incorporation into Virus-Like Particles

(2008) Erica Strable et al.   BIOCONJUGATE CHEMISTRY

Polyvalency: A promising strategy for drug design

(2008) David Vance et al.   BIOTECHNOLOGY AND BIOENGINEERING

Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability

(2008) Michael M. Schmidt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition

(2008) Zoë A. E. Waller et al.   CHEMICAL COMMUNICATIONS

Hyaluronan, CD44 and Emmprin: Partners in cancer cell chemoresistance

(2008) Bryan P. Toole et al.   DRUG RESISTANCE UPDATES

Self-assembled DNA nanostructures for distance-dependent multivalent ligand–protein binding

(2008) Sherri Rinker et al.   Nature Nanotechnology