A combination of two antibodies recognizing non-overlapping epitopes of HER2 induces kinase activity-dependent internalization of HER2

Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity

(2015) H. J. Jacobsen et al.   CLINICAL CANCER RESEARCH

Targeting Three Distinct HER2 Domains with a Recombinant Antibody Mixture Overcomes Trastuzumab Resistance

(2015) M. W. Pedersen et al.   MOLECULAR CANCER THERAPEUTICS

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics

(2014) Carlos L. Arteaga et al.   CANCER CELL

Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions

(2014) Komal Jhaveri et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

ErbB/HER protein-tyrosine kinases: Structures and small molecule inhibitors

(2014) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Clathrin-Independent Pathways of Endocytosis

(2014) S. Mayor et al.   Cold Spring Harbor Perspectives in Biology

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis

(2012) Christian Berger et al.   EXPERIMENTAL CELL RESEARCH

Preubiquitinated chimeric ErbB2 is constitutively endocytosed and subsequently degraded in lysosomes

(2012) Tram Thu Vuong et al.   EXPERIMENTAL CELL RESEARCH

Clathrin-independent endocytosis: mechanisms and function

(2011) Kirsten Sandvig et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging

(2011) J. L. Macdonald-Obermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

(2010) J. B. Spangler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking

(2009) I. H. Madshus et al.   JOURNAL OF CELL SCIENCE

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Persistent elimination of ErbB-2/HER2-overexpressing tumors using combinations of monoclonal antibodies: Relevance of receptor endocytosis

(2009) T. Ben-Kasus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

(2009) E. S. Ehrlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocytosis and intracellular trafficking of ErbBs

(2008) Alexander Sorkin et al.   EXPERIMENTAL CELL RESEARCH

Geldanamycin-Induced Down-Regulation of ErbB2 from the Plasma Membrane Is Clathrin Dependent but Proteasomal Activity Independent

(2008) N. M. Pedersen et al.   MOLECULAR CANCER RESEARCH

Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity

(2008) M Scaltriti et al.   ONCOGENE