Article
Obstetrics & Gynecology
Brian J. Koos, Jeffrey A. Gornbein
Summary: This metabolomics study identified a high-accuracy model for predicting gestational diabetes mellitus in early pregnancy. The research showed that certain metabolites were independently associated with gestational diabetes mellitus and could be used as predictive markers. This finding contributes to future studies on early therapeutic interventions for gestational diabetes mellitus.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Developmental Biology
Avery C. Kramer, Thomas Jansson, Tracy L. Bale, Theresa L. Powell
Summary: Altered placental function may mediate the link between the maternal environment and fetal growth and development, through nutrient sensing, modulation of transporters, and changes in extracellular vesicles. Maternal diet and stress can also influence fetal development and metabolism, and fetal growth restriction may increase the risk of chronic disease later in life.
Article
Biology
Yuping Zhou, Baoxia Gu, Geraldine Brichant, Jay Prakash Singh, Huan Yang, Hao Chang, Yanding Zhao, Chao Cheng, Zhong-Wu Liu, Myles H. Alderman, Lingeng Lu, Xiaoyong Yang, Xiao-Bing Gao, Hugh S. Taylor
Summary: A study found that mice offspring exposed to estriol (E-3) during pregnancy had increased fertility and better pregnancy outcomes. These offspring also showed decreased anxiety and increased exploratory behavior. E-3 acts on estrogen receptors, recruiting epigenetic modifiers to alter gene expression and affect organ development and brain function.
Article
Dermatology
Jemin Kim, Kyung Bae Chung, Young In Lee, Jihee Kim, Ju Hee Lee
Summary: The study found that the pattern and degree of sclerosis in morphea are associated with the anatomic site of the lesion, severe inflammation, and concomitant autoimmune disease. Increased risk of poor treatment response is correlated with tissue eosinophils and basal pigmentation. Skin biopsy samples may show specific features of morphea that indicate the need for aggressive treatment and monitoring.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Immunology
Patrick Coit, Kaila L. Schollaert, Emily M. Mirizio, Kathryn S. Torok, Amr H. Sawalha
Summary: The study assessed DNA methylation differences between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS), revealing distinct epigenetic patterns and unique methylated genes in both diseases. Compared to healthy controls, differential methylation sites and genes were identified in jSSc and jLS, indicating potential novel diagnostic biomarkers for localized scleroderma. Pathway analysis showed enrichment of inflammatory pathways in jSSc and the HIPPO signaling pathway in jLS, highlighting different biological processes involved in each condition.
CLINICAL IMMUNOLOGY
(2021)
Review
Cell Biology
Avik Dutta, Harini Venkataganesh, Paul E. Love
Summary: This review summarizes recent findings on the role of epigenetic regulators in T cell differentiation in both mice and humans. It provides new insights into how dysregulation of these processes can lead to cancer or autoimmune diseases.
Review
Immunology
Mingxuan Chi, Kuai Ma, Yunlong Li, Min Quan, Zhongyu Han, Zhaolun Ding, Xin Liang, Qinxiu Zhang, Linjiang Song, Chi Liu
Summary: Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by multiple immunoregulatory abnormalities that lead to damage to various tissues and organs. Researchers have identified aberrant expression of miRNAs in SLE patients, which may be associated with abnormal immune responses and disease progression in SLE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Brian Skaug, Marka A. Lyons, William R. Swindell, Gloria A. Salazar, Minghua Wu, Tuan M. Tran, Julio Charles, Connor P. Vershel, Maureen D. Mayes, Shervin Assassi
Summary: In systemic sclerosis (SSc), skin gene expression dysregulation is associated with skin thickness, with immune cell and fibroblast signatures playing a role in disease severity. In early diffuse SSc, skin gene expression changes over time exhibit a trend towards normalization.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Rebecca L. Ross, Clarissa Corinaldesi, Gemma Migneco, Ian M. Carr, Agne Antanaviciute, Christopher W. Wasson, Antonio Carriero, Jorg H. W. Distler, Steve Holmes, Yasser M. El-Sherbiny, Clive S. McKimmie, Francesco Del Galdo
Summary: Human pDC play a significant role in inflammation and immune-driven skin fibrosis, which can be effectively blocked by BDCA2-targeting, providing direct evidence supporting the development of attenuation of pDC function as a therapeutic application for SSc.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Agriculture, Dairy & Animal Science
Carl Robertson Dahlen, Samat Amat, Joel S. Caton, Matthew S. Crouse, Wellison Jarles Da Silva Diniz, Lawrence P. Reynolds
Summary: Paternal programming refers to the influence of the sire's experiences before mating on the phenotype of the offspring through the alteration of semen. This can be achieved through epigenetic mechanisms, oxidative stress, cytokines, and the seminal microbiome. Various factors such as nutrition, stress, exercise, and exposure to drugs can induce paternal programming responses, resulting in observable effects in the offspring's phenotype.
ANIMAL REPRODUCTION
(2023)
Review
Genetics & Heredity
Ilaria Barchetta, Jeanette Arvastsson, Luis Sarmiento, Corrado M. Cilio
Summary: This article discusses the pathogenesis of organ-specific autoimmune diseases and the contribution of environmental factors, highlighting the role of epigenetic changes induced by maternal conditions in preventing type 1 diabetes through adjustment of the maternal environment.
Review
Immunology
Cristina Municio, Gabriel Criado
Summary: Trained immunity refers to immunological memory developed in innate immune cells, leading to an enhanced inflammatory response. This process involves rewiring cell metabolism and epigenetic reprogramming. Unrestrained activation may contribute to chronic inflammation and tissue destruction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Shervin Assassi, Elizabeth R. Volkmann, W. Jim Zheng, Xuan Wang, Holly Wilhalme, Marka A. Lyons, Michael D. Roth, Donald P. Tashkin
Summary: The study characterized gene expression changes in peripheral blood cells (PBC) from systemic sclerosis-related interstitial lung disease (SSc-ILD) patients treated with mycophenolate mofetil (MMF) or cyclophosphamide (CYC). The results showed that baseline lymphoid lineage modules predicted better forced vital capacity (FVC) course in MMF-treated patients, while baseline myeloid lineage and inflammation modules predicted worse FVC course. The study highlights the importance of baseline transcript scores in predicting treatment response in SSc-ILD patients.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Oncology
Peter C. C. Allen, Sarah Smith, Robert C. C. Wilson, Jena R. R. Wirth, Nathan H. H. Wilson, DeAnna Baker Frost, Jonathan Flume, Gary S. S. Gilkeson, Melissa A. A. Cunningham, Carl D. D. Langefeld, Devin M. M. Absher, Paula S. S. Ramos
Summary: This study investigated DNA methylation and gene expression patterns in classical monocytes in a health disparity population. The results showed modest differences in DNA methylation and gene expression between cases and controls. Contrasting with results found in other blood cell types in largely European-descent groups, this study supports the existence of DNA methylation and gene expression variability among different cell types and individuals of different backgrounds.
CLINICAL EPIGENETICS
(2023)
Article
Rheumatology
Yannick Allanore, Madelon C. Vonk, Oliver Distler, Arata Azuma, Maureen D. Mayes, Martina Gahlemann, Alexandra James, Veronika Kohlbrenner, Margarida Alves, Dinesh Khanna, Kristin B. Highland
Summary: Nintedanib can reduce the decline in forced vital capacity (FVC) in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) and has consistent safety profile and FVC outcomes in both short-term and long-term use.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Iliana Sciarra, Massimiliano Vasile, Alessia Carboni, Katia Stefanantoni, Nicoletta Iannace, Carlotta Angelelli, Antongiulio G. Scarno, Guido Valesini, Valeria Riccieri
Summary: This study confirms the involvement of macrocirculation in SSc patients, detecting the presence of subclinical ATS markers more frequently in patients compared to healthy controls. Framingham score, diastolic dysfunction of left ventricle, and limited cutaneous form of the disease appeared to be associated with a higher risk of developing ATS.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Francesca Motta, Veronica Codullo, Veronique Ramoni, Stefania Cesari, Giuseppina Ferrario, Giacomo Fiandrino, Fausta Beneventi, Stefania Rampello, Hanna Johnsson, Carlomaurizio Montecucco, Gerard J. Graham
Summary: This study aimed to compare placental alterations in SSc patients with other rheumatic diseases and healthy controls. The results showed that inflammatory changes characterize placentas from rheumatic disease patients and may predispose to obstetric complications.
Article
Pediatrics
Andrea Bassi, Cesare Filippeschi, Teresa Oranges, Chiara Caporalini, Alessandro Pini, Patrizia Nardini, Roberta Marie Gentile, Luca Filippi
Summary: The research found a significant increase in the expression of beta(3)-AR in hemangioma biopsies from patients nonresponsive to propranolol treatment. This suggests a possible role of beta(3)-AR in the pathogenesis of hemangiomas and a potential new therapeutic target.
PEDIATRIC RESEARCH
(2022)
Meeting Abstract
Rheumatology
E. Molteni, F. Ceccarelli, C. Castellani, F. Giardina, C. Alessandri, M. Di Franco, V. Riccieri, F. R. Spinelli, R. Scrivo, R. Priori, F. Conti
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Chemistry, Medicinal
Luca Filippi, Alessandro Pini, Maurizio Cammalleri, Paola Bagnoli, Massimo Dal Monte
Summary: The role of beta-adrenoceptors in hypoxia-driven diseases, such as infantile hemangiomas and retinopathy of prematurity, has been highlighted. The upregulation of beta 3-ARs by hypoxia in both cancer and embryo development suggests potential similarities in their functions.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Claudia Ferlito, Vincenzo Visco, Roberto Biselli, Maria Sofia Cattaruzza, Giulia Carreras, Gerardo Salerno, Florigio Lista, Maria Rosaria Capobianchi, Concetta Castilletti, Daniele Lapa, Guido Antonelli, Massimo Gentile, Maurizio Sorice, Gloria Riitano, Giuseppe Lucania, Valeria Riccieri, Fabrizio Mainiero, Antonio Angeloni, Marco Lucarelli, Giampiero Ferraguti, Alberto Autore, Marco Lastilla, Simonetta Salemi, Michela Ileen Biondo, Andrea Picchianti-Diamanti, Sara Caporuscio, Raffaela Teloni, Sabrina Mariotti, Roberto Nisini, Raffaele D'Amelio
Summary: This study analyzed the possible late appearance of side effects and the half-life of induced antibodies in a military cohort. The results showed no late side effects and confirmed the long duration of certain vaccine-induced antibodies.
Review
Oncology
Agata Janowska, Michela Iannone, Cristian Fidanzi, Marco Romanelli, Luca Filippi, Marzia Del Re, Manuella Martins, Valentina Dini
Summary: This paper reviews the genetic profile of melanoma cells from their appearance, through the dormant state to their reactivation leading to metastasis. A complete genetic profile will identify the genes responsible for metastasis appearance, contributing to the creation of new therapeutic targets that keep cells in a dormant state and prevent melanoma tumor cells from spreading.
Article
Cell Biology
Rosario Amato, Francesco Pisani, Emiliano Laudadio, Maurizio Cammalleri, Martina Lucchesi, Silvia Marracci, Luca Filippi, Roberta Galeazzi, Maria Svelto, Massimo Dal Monte, Paola Bagnoli
Summary: The hypoxia-inducible factor (HIF)-1 plays a major role in the homeostatic response to hypoxia by activating genes involved in neovessel proliferation. In the retina, hypoxia leads to overstimulation of beta-adrenoceptors (beta-ARs) and the formation of pathogenic blood vessels. This study demonstrates that HIF-1 regulates the expression of the beta 3-AR gene in the retina, and its involvement in the hypoxia response.
Review
Biochemistry & Molecular Biology
Martina Lucchesi, Silvia Marracci, Rosario Amato, Luca Filippi, Maurizio Cammalleri, Massimo Dal Monte
Summary: This article reviews the literature data on retinopathy of prematurity (ROP) and discusses whether ROP can be considered a neurodegenerative disease. It also describes the neurologic damage and outcomes associated with ROP.
Article
Chemistry, Multidisciplinary
Luca Mesin, Francesco Ponzio, Christian Francesco Carlino, Matteo Lenge, Alice Noris, Maria Carmela Leo, Michela Sica, Kathleen McGreevy, Erica Leila Ahngar Fabrik, Flavio Giordano
Summary: This study proposes a machine learning approach to identify patients with higher risk of syringomyelia and clinical deterioration among those with Chiari I malformation, using MRI images and patient information.
APPLIED SCIENCES-BASEL
(2022)
Article
Pediatrics
Rosa Teresa Scaramuzzo, Paola Bagnoli, Massimo Dal Monte, Maurizio Cammalleri, Alessandro Pini, Sandy Ballini, Anna Bendinelli, Ielizza Desideri, Massimiliano Ciantelli, Luca Filippi
Article
Computer Science, Interdisciplinary Applications
Antonio Marzola, Kathleen S. McGreevy, Federico Mussa, Yary Volpe, Lapo Governi
Summary: This article introduces a new reconstruction method called HyM3D, which can automatically restore defects on the surface of the cranium while ensuring symmetry and continuity. By combining template-based methods with surface interpolation algorithms, this method has been proven reliable and effective, even in complex cases, without requiring user intervention.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Luca Filippi, Francesca Pascarella, Alessandro Pini, Maurizio Cammalleri, Paola Bagnoli, Riccardo Morganti, Francesca Innocenti, Nicola Castagnini, Alice Melosi, Rosa Teresa Scaramuzzo
Summary: The embryo and fetus grow in a hypoxic environment and intrauterine oxygen levels fluctuate throughout pregnancy. A retrospective study on healthy newborns with gestational age < 37 weeks showed a progressive decrease in oxygen levels starting from the 23rd week until the 33-34th week of gestation, followed by an increase in fetal oxygenation until birth. This biphasic trend indicates the role of placenta in regulating oxygen availability to promote stemness and differentiation at specific times and tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Luc Pijnenburg, Margherita Giannini, Maude Bouchard-Marmen, Laurent Arnaud, Simone Barsotti, Silvia Bellando-Randone, Livio Bernardi, Paola Bini, Jelena Blagojevic, Veronica Codullo, Marion Couderc, Claire De Moreuil, Emanuelle Dernis, Luca Diamanti, Jean Jacques Dubost, Fanny Duval, Giacomo Emmi, Jean-Marc Galempoix, Bernard Geny, Jacques-Eric Gottenberg, Monica Groza, Aurelien Guffroy, Isabelle Guichard, Philippe Guilpain, Baptiste Hervier, Marie Hudson, Luca Iaccarino, Florenzo Iannone, Delphine Lebrun, Enrico Marchioni, Kuberaka Mariampillai, Francois Maurier, Marta Mosca, Aleksandra Nadaj-Pakleza, Carlotta Nannini, Jean-Maxime Piot, Sergio Prieto-Gonzalez, Nicolas Poursac, Eglantine Rouanet, Jeremie Sellam, Albert Selva-O'Callaghan, Francois Severac, Jean Sibilia, Guilhem Sole, Antoine Soulages, Benjamin Terrier, Anne Tournadre, Yves Troyanov, Nathalie Vernier, Veronique Vesperini, Jean-Francois Viallard, Rahima Ziane, Lorenzo Cavagna, Alain Meyer
Summary: Dropped head or bent spine syndrome (DH/BS) in patients with inflammatory myopathies (IM) is a marker of severity and is associated with systemic sclerosis (SSc).
Review
Rheumatology
M. Di Battista, S. Barsotti, M. Orlandi, G. Lepri, V Codullo, A. Della Rossa, S. Guiducci, F. Del Galdo
Summary: Systemic sclerosis is a rare and chronic connective tissue disease with complex multi-organ clinical manifestations. Studies in 2020 have made significant contributions to enrich the understanding of the pathogenesis, organ involvement, and treatment of this severe disease.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
