Review
Biotechnology & Applied Microbiology
Tapas Kumar Goswami, Mithilesh Singh, Manish Dhawan, Saikat Mitra, Talha Bin Emran, Ali A. Rabaan, Abbas Al Mutair, Zainab Al Alawi, Saad Alhumaid, Kuldeep Dhama
Summary: This article discusses the mechanism of autoimmune diseases and the crucial role of regulatory T cells (Tregs). Tregs control immune suppression by regulating various immune cells, protecting the body from the impact of autoimmune diseases. Studying T cell markers and therapeutic approaches can help reduce the severity of autoimmune-related conditions.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Shi-Peng Li, Jin-Ming Zhang, Xiao-Jie Chen, Guang-Peng Zhou, Jie Sun, Bin Cui, Liu-Xin Zhou, Hai-Ming Zhang, Wei-Tao Que, Li-Ying Sun, Zhi-Jun Zhu
Summary: DPT cells are increased in liver transplant patients, especially in rejection cases. These cells show contiguity with Treg cells and their exhaustion is enhanced by increased PD-1 expression. These findings suggest that DPT cells may play a role in immune tolerance and could be targeted for preventing liver transplant rejection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Hoa Le Mai, Nicolas Degauque, Marine Lorent, Marie Rimbert, Karine Renaudin, Richard Danger, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Sabine Le Bot, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: This study found that kidney allograft rejection is associated with an imbalance between immune cells with effector/memory functions and those with regulatory properties, manifested as a decrease in the percentage of circulating B cells and an increase in the ratio of CD28-CD8+ T cells to Tregs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mahdieh Naghavi Alhosseini, Marianna Palazzo, Luigi Cari, Simona Ronchetti, Graziella Migliorati, Giuseppe Nocentini
Summary: B-acute lymphoblastic leukemia (B-ALL) is a common pediatric cancer. Treg and exhausted CD8(+) T cells play important roles in its development and maintenance. In this study, the expression of 20 Treg/CD8 exhaustion markers was evaluated and their correlation with other factors was analyzed. The results suggest that T cells expressing CD39, CTLA-4, TNFR2, TIGIT, and TIM-3 may promote B-ALL progression and targeted immunotherapy against these markers could be a promising approach for treating B-ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Benedetta De Ponte Conti, Annarita Miluzio, Fabio Grassi, Sergio Abrignani, Stefano Biffo, Sara Ricciardi
Summary: The systematic analysis on translation rate of tumor-infiltrating lymphocytes (TILs) in humans and mice shows that high translation levels are associated with mTORC1 activation and low levels are correlated with hypoxia. CD8 translating cells exhibit a cytotoxic phenotype, while CD4 translating cells are mainly regulatory T cells with immunosuppressive functions.
Review
Immunology
Romy Steiner, Nina Pilat
Summary: Since the discovery of regulatory T cells (Tregs) as crucial regulators of immune tolerance, they have become a promising tool for inducing donor-specific tolerance in transplantation medicine. Various approaches, such as adoptive transfer, ex vivo expansion, and in vivo stimulation, have been explored to enhance Treg therapy. Furthermore, next generation concepts, such as CARs, TRUCKs, and BARs, are being investigated for improving Treg function. Clinical trials have shown promise, but long-term results and efficacy remain limited, and challenges for clinical translation remain open.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Sabrina Ceeraz, Charlotte R. Thompson, Richard Beatson, Ernest H. Choy
Summary: T regulatory cell therapy offers a new approach for treating autoimmune diseases and transplantation. CD8(+) Treg cells, particularly the CD8(+)CD28(-) subset, have been shown to be effective in preclinical models, although their impaired functionality in disease limits their effectiveness in immunosuppression. The review focuses on harnessing CD8(+) Treg cell therapy in clinical settings to aid current treatments for autoimmune and inflammatory conditions.
Article
Immunology
Adrian Liston, Meryem Aloulou
Summary: CD8(+)Foxp3(+) cells, often neglected, have regulatory functions similar to CD4(+)Foxp3(+)Treg cells but with distinct characteristics.
IMMUNOLOGY LETTERS
(2022)
Review
Immunology
Zhan Xu, Xue Jiang, Xueyu Dai, Bin Li
Summary: The COVID-19 pandemic has caused severe global impact, with activated immune response as a key feature. Regulatory T cells play a crucial role in suppressing inflammatory response and tissue repair. Research on the changes of FOXP3(+) Tregs in COVID-19 patients, their relationship with disease severity, and the potential role of FOXP3(+) Tregs in SARS-CoV-2 infection are discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ilenia Pacella, Ilenia Cammarata, Carmela Martire, Giuseppina Brancaccio, Giovanni Battista Gaeta, Vincenzo Barnaba, Silvia Piconese
Summary: The study revealed that in patients with chronic HBV infection receiving NUC therapy and having advanced hepatic fibrosis, the frequency of AE-specific CD8(+) T cells was significantly increased. Different specificities of CD8(+) T cells were found to populate distinct subpopulations, suggesting a link between AE-specific T cells and advanced liver fibrosis.
LIVER INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Pawan K. Gupta, Jennifer B. Allocco, Jane M. Fraipont, Michelle L. McKeague, Peter Wang, Michael S. Andrade, Christine McIntosh, Luqiu Chen, Ying Wang, Yan Li, Jorge Andrade, Jose R. Conejo-Garcia, Anita S. Chong, Maria-Luisa Alegre
Summary: This study investigates the susceptibility of Tconvs to Treg suppression during tolerance induction in transplantation. The findings suggest that transplantation tolerance is associated with an increased sensitivity of alloreactive Tconvs to Treg suppression, which is regulated by the expression of the transcription factor Satb1. Targeting Satb1 could potentially be a strategy to improve transplant outcomes by modulating Treg-sparing immunosuppressive therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Yifei Feng, Yan Lu
Summary: This paper provides a synopsis of current practices in vitiligo treatment and introduces the progress in identifying new molecular targets and applying molecular-targeted therapies, offering valuable insights for establishing further precision medicine for vitiligo patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Severine Menoret, Laurent Tesson, Severine Remy, Victor Gourain, Celine Serazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Helene Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Summary: In this study, a Foxp3-EGFP rat transgenic line was created to genetically tag CD4(+) and CD8(+) FOXP3(+) regulatory T cells. CD4(+)EGFP(+) Treg were found to be 5-10 times more frequent than CD8(+)EGFP(+) Treg. RNAseq analysis provided insights into the transcriptome of CD8(+) Treg, allowing for a better understanding of their phenotype and function.
