Defining the molecular mechanisms of HIV-1 Tat secretion: PtdIns(4,5)P2 at the epicenter

PTEN Regulates PI(3,4)P 2 Signaling Downstream of Class I PI3K

(2017) Mouhannad Malek et al.   MOLECULAR CELL

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

(2017) Matthew J. Shurtleff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathways of Unconventional Protein Secretion

(2017) Catherine Rabouille   TRENDS IN CELL BIOLOGY

Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components

(2017) Julia P Steringer et al.   eLife

Impact of Genetic Variations in HIV-1 Tat on LTR-Mediated Transcription via TAR RNA Interaction

(2017) Larance Ronsard et al.   Frontiers in Microbiology

Inhibition of Non Canonical HIV-1 Tat Secretion Through the Cellular Na + ,K + -ATPase Blocks HIV-1 Infection

(2017) Silvia Agostini et al.   EBioMedicine

Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K2P background K+ channel TASK-2

(2017) María Isabel Niemeyer et al.   Scientific Reports

HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression

(2016) Pejman Rahimian et al.   Journal of Neuroinflammation

Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein

(2016) Pejman Rahimian et al.   JOURNAL OF NEUROVIROLOGY

Biomarkers of chemotaxis and inflammation in cerebrospinal fluid and serum in individuals with HIV-1 subtype C versus B

(2016) Sergio M. de Almeida et al.   JOURNAL OF NEUROVIROLOGY

Utilization of HIV-1 envelope V3 to identify X4- and R5-specific Tat and LTR sequence signatures

(2016) Gregory C. Antell et al.   Retrovirology

The inhibition of microRNAs by HIV-1 Tat suppresses beta catenin activity in astrocytes

(2016) Luca Sardo et al.   Retrovirology

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

(2016) Matthew J Shurtleff et al.   eLife

HIV-1 Genetic Variation Resulting in the Development of New Quasispecies Continues to Be Encountered in the Peripheral Blood of Well-Suppressed Patients

(2016) Will Dampier et al.   PLoS One

HIV-Tat Protein Forms Phosphoinositide-dependent Membrane Pores Implicated in Unconventional Protein Secretion

(2015) Marcel Zeitler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unconventional Secretion of Fibroblast Growth Factor 2—A Novel Type of Protein Translocation across Membranes?

(2015) Julia P. Steringer et al.   JOURNAL OF MOLECULAR BIOLOGY

Emerging Roles of Exosomes in Normal and Pathological Conditions: New Insights for Diagnosis and Therapeutic Applications

(2015) Julieta De Toro et al.   Frontiers in Immunology

Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells

(2014) Amy E. Baxter et al.   Cell Host & Microbe

A Direct Role for ATP1A1 in Unconventional Secretion of Fibroblast Growth Factor 2

(2014) Sonja Zacherl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Basic Domain of HIV-Tat Transactivating Protein Is Essential for Its Targeting to Lipid Rafts and Regulating Fibroblast Growth Factor-2 Signaling in Podocytes Isolated from Children with HIV-1-Associated Nephropathy

(2014) X. Xie et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells

(2014) Sami Kukkonen et al.   Retrovirology

Free Energy of Translocating an Arginine-Rich Cell-Penetrating Peptide across a Lipid Bilayer Suggests Pore Formation

(2013) Kun Huang et al.   BIOPHYSICAL JOURNAL

The Presence of HIV-1 Tat Protein Second Exon Delays Fas Protein-mediated Apoptosis in CD4+T Lymphocytes

(2013) María Rosa López-Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes Derived from HIV-1-infected Cells Contain Trans-activation Response Element RNA

(2013) Aarthi Narayanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of anti-tat antibodies in CSF of individuals with HIV-associated neurocognitive disorders

(2013) M. Bachani et al.   JOURNAL OF NEUROVIROLOGY

Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence

(2013) Vasudev R Rao et al.   Retrovirology

The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

(2012) Saumya Pant et al.   BIOCHEMICAL PHARMACOLOGY

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

(2012) Marlène Dreux et al.   Cell Host & Microbe

HIV-1 Tat protein inhibits neurosecretion by binding to phosphatidylinositol 4,5-bisphosphate

(2012) P. Tryoen-Toth et al.   JOURNAL OF CELL SCIENCE

The Viral Protein Tat Can Inhibit the Establishment of HIV-1 Latency

(2012) D. A. Donahue et al.   JOURNAL OF VIROLOGY

Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

(2012) Michelle Demory Beckler et al.   MOLECULAR & CELLULAR PROTEOMICS

Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated Neuronal dysfunction

(2012) G Hu et al.   Cell Death & Disease

Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse

(2011) Amanda N. Carey et al.   BEHAVIOURAL BRAIN RESEARCH

Current understanding of HIV-associated neurocognitive disorders pathogenesis

(2011) Patrick Gannon et al.   CURRENT OPINION IN NEUROLOGY

Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment

(2011) Luna Li et al.   JOURNAL OF NEUROVIROLOGY

Inflammasome activation and IL-1  target IL-1  for secretion as opposed to surface expression

(2011) A. Fettelschoss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microvesicles as mediators of intercellular communication in cancer—the emerging science of cellular ‘debris’

(2011) Tae Hoon Lee et al.   Seminars in Immunopathology

Cell-Penetrating HIV1 TAT Peptides Can Generate Pores in Model Membranes

(2010) Corina Ciobanasu et al.   BIOPHYSICAL JOURNAL

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

(2010) Fabienne Rayne et al.   EMBO JOURNAL

Microparticles as a source of extracellular DNA

(2010) David S. Pisetsky et al.   IMMUNOLOGIC RESEARCH

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microvesicles: mediators of extracellular communication during cancer progression

(2010) V. Muralidharan-Chari et al.   JOURNAL OF CELL SCIENCE

Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon

(2010) M. R. Lopez-Huertas et al.   NUCLEIC ACIDS RESEARCH

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine-Rich Peptides Destabilize the Plasma Membrane, Consistent with a Pore Formation Translocation Mechanism of Cell-Penetrating Peptides

(2009) H.D. Herce et al.   BIOPHYSICAL JOURNAL

Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells

(2009) Bok Hong et al.   BMC GENOMICS

HIV-1 Tat is unconventionally secreted through the plasma membrane

(2009) Fabienne Rayne et al.   CELL BIOLOGY INTERNATIONAL

Exosomes: proteomic insights and diagnostic potential

(2009) Richard J Simpson et al.   Expert Review of Proteomics

Mechanism for HIV-1 Tat Insertion into the Endosome Membrane

(2009) Hocine Yezid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions

(2009) I. van den Bout et al.   JOURNAL OF CELL SCIENCE

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

HIV TAT Forms Pores in Membranes by Inducing Saddle-Splay Curvature: Potential Role of Bidentate Hydrogen Bonding

(2008) Abhijit Mishra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Unconventional Mechanisms of Protein Transport to the Cell Surface of Eukaryotic Cells

(2008) Walter Nickel et al.   Annual Review of Cell and Developmental Biology

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Multivesicular bodies: co-ordinated progression to maturity

(2008) Philip G Woodman et al.   CURRENT OPINION IN CELL BIOLOGY

Rerouting of fibroblast growth factor 2 to the classical secretory pathway results in post-translational modifications that block binding to heparan sulfate proteoglycans

(2008) Sabine Wegehingel et al.   FEBS LETTERS

Unconventional secretion of fibroblast growth factor 2 and galectin-1 does not require shedding of plasma membrane-derived vesicles

(2008) Claudia Seelenmeyer et al.   FEBS LETTERS

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Proteomic profiling of exosomes: Current perspectives

(2008) Richard J. Simpson et al.   PROTEOMICS

A Direct Role for Phosphatidylinositol-4,5-bisphosphate in Unconventional Secretion of Fibroblast Growth Factor 2

(2008) Koen Temmerman et al.   TRAFFIC