Review
Health Care Sciences & Services
Luan Oliveira Ferreira, Victoria Winkler Vasconcelos, Janielle de Sousa Lima, Jaime Rodrigues Vieira Neto, Giovana Escribano da Costa, Jordana de Castro Esteves, Sallatiel Cabral de Sousa, Jonathan Almeida Moura, Felipe Ruda Silva Santos, Joao Monteiro Leitao Filho, Matheus Ramos Protasio, Pollyana Sousa Araujo, Claudio Jose da Silva Lemos, Karina Dias Resende, Dielly Catrina Favacho Lopes
Summary: Patients undergoing coronary revascularization with extracorporeal circulation or cardiopulmonary bypass may develop systemic inflammatory response due to biochemical changes in the microcirculation. Inflammatory signaling pathways can be activated by surgical incision, reperfusion injury, and blood contact with non-endothelial membranes, leading to the production and activation of inflammatory cells, cytokine production, and oxidative stress. Addressing new perspectives for intraoperative treatment and management may reduce this inflammatory storm, improve prognosis, and potentially lower mortality rates in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Geology
S. M. Hall, B. S. Van Gosen, R. A. Zielinski
Summary: More than 4,000 sandstone-hosted uranium occurrences on the Colorado Plateau contain over 1.2 billion pounds of mined and in situ U3O8. Most of the resources are found in the Triassic Chinle and Jurassic Morrison Formations. The uranium source is likely volcanic ash preserved as bentonitic mudstones in the Morrison Formation and volcanic clasts, ash shards, and bentonitic clay in the Chinle Formation. Vanadium likely originated from iron-titanium oxides or similar minerals in bleached red beds associated with the Morrison Formation.
ORE GEOLOGY REVIEWS
(2023)
Article
Materials Science, Composites
Yucong Yu, Zhi-Yuan Zhu, Hao Ye, Guo-Tao Chen, Ming-Bang Wu, Xiangdong Kong, Jiri Militky, Juming Yao
Summary: Magnetic lysozyme@Fe3O4 composites were prepared via amyloid-like assembly, which exhibited magnetism and excellent binding affinity towards uranium. In addition, the composites also showed outstanding photothermal properties. These properties facilitated the adsorption of uranyl ions and improved the selectivity under sunlight.
COMPOSITES COMMUNICATIONS
(2022)
Article
Environmental Sciences
Teemu J. Ronkko, Maija-Riitta Hirvonen, Mikko S. Happo, Tuukka Ihantola, Henri Hakkarainen, Maria-Viola Martikainen, Cheng Gu, Qin'geng Wang, Jorma Jokiniemi, Mika Komppula, Pasi I. Jalava
Summary: The health risks of air pollutants and ambient particulate matter are widely known, but the connections between PM composition and toxicological effects are not fully understood. This study shows evidence of varying toxicological effects of urban PM at equal mass concentrations, influenced by PM composition and emission source characteristics. Traffic and oil/fuel combustion emissions contribute substantially to the observed spatiotemporal variations of toxicological responses.
ENVIRONMENTAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Peter Breining, Anne Lier Frolund, Jesper Falkesgaard Hojen, Jesper Damsgaard Gunst, Nina B. Staerke, Eva Saedder, Manuel Cases-Thomas, Paul Little, Lars Peter Nielsen, Ole S. Sogaard, Mads Kjolby
Summary: Camostat mesylate is a potent inhibitor of the serine protease TMPRSS2, effectively hindering virus-cell membrane fusion and replication, reducing viral load, and potentially improving patient outcomes. Ongoing clinical trials are investigating its potential as an antiviral agent against COVID-19.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Harry Jang, James Louis-Jean, Frederic Poineau
Summary: UO2F2 microspheres were successfully prepared for the first time using a new fluorination method and HF gas produced in situ. The microspheres were characterized using PXRD and SEM.
Review
Pharmacology & Pharmacy
Sergio Pandolfi, Salvatore Chirumbolo, Giovanni Ricevuti, Luigi Valdenassi, Geir Bjorklund, Roman Lysiuk, Monica Daniela Dosa, Larysa Lenchyk, Serafino Fazio
Summary: The COVID-19 pandemic had a significant impact on mankind, especially in Italy. Through post-mortem autopsies, immune-thrombosis of the lungs was identified as the major pathogenesis of COVID-19. Early anti-inflammatory therapy may be effective in treating endothelial inflammation and immune-thrombosis caused by COVID-19.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Chemistry, Applied
Qi Xin, Qingliang Wang, Jiali Gan, Zhiwu Lei, Eming Hu, Hongqing Wang, Hongqiang Wang
Summary: In this study, a novel adsorbent SPCCHC was prepared and showed good adsorption selectivity for U(VI). The introduction of phosphate group greatly improved the adsorption effect on uranium and SPCCHC exhibited good recycling performance.
CARBOHYDRATE POLYMERS
(2023)
Article
Materials Science, Composites
Ming-Bang Wu, Hao Ye, Shi-Cheng Liu, Yu-Qi Huang, Jia-Min Jin, Juming Yao
Summary: In this study, wooden composite separators with Fe3+/salicylaldoxime coatings were used to selectively extract uranium from seawater. The coatings demonstrated excellent uranium/vanadium selectivity and antibacterial properties, while the wooden separators showed lower mass resistances and were suitable for practical dynamic adsorption due to the vertically aligned channels and high porosities.
COMPOSITES COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Dacquin M. Kasumba, Sandrine Huot, Elise Caron, Audray Fortin, Cynthia Laflamme, Natalia Zamorano Cuervo, Felix Lamontagne, Marc Pouliot, Nathalie Grandvaux
Summary: The first line of defense against respiratory viruses is the antiviral and proinflammatory cytokine response in infected respiratory epithelial cells. This study investigates the role of the epithelial Dual Oxidase 2 (DUOX2) in the inflammatory cytokine response during respiratory virus infection. The findings demonstrate that DUOX2 selectively affects the induction of specific cytokines and chemokines, and it also influences the migration, adhesion, and degranulation of human neutrophils.
Article
Environmental Sciences
Anja Reckhardt, Stephan L. Seibert, Tobias Holt, Janis Ahrens, Melanie Beck, Gudrun Massmann, Hans-Jurgen Brumsack
Summary: The study revealed the presence of various redox-sensitive metals in freshwater lenses, where their concentrations are influenced by biogeochemical processes. Additionally, the age and redox characteristics of groundwater are linked to metal concentrations. The sources, removal, and transformation processes of metals differ significantly in different redox environments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Editorial Material
Medicine, Research & Experimental
Charles P. Thompson, Abhijit Jagdale, Gregory Walcott, Hayato Iwase, Jeremy B. Foote, Randall Q. Cron, Hidetaka Hara, David C. Cleveland, David K. C. Cooper
Summary: The inflammatory response following surgical procedures and xenograft exposure may have detrimental effects on pig heart graft function and recipient baboon pulmonary function, as well as impacting immune response to the graft. Strategies to reduce the inflammatory response, such as white blood cell filtration and immunosuppressive therapy, could potentially improve outcomes of genetically engineered pig heart transplantation.
XENOTRANSPLANTATION
(2021)
Review
Nutrition & Dietetics
Patricia Ruiz-Iglesias, Abril Gorgori-Gonzalez, Malen Massot-Cladera, Margarida Castell, Francisco J. Perez-Cano
Summary: Flavonoids are receiving increased attention for their antioxidant, cardioprotective, and anti-inflammatory properties. Some studies suggest that anthocyanins may enhance exercise performance, but further research is needed to explore their relationship with immune function.
Article
Chemistry, Analytical
Lihua Zuo, Hongyu Guo, Zhenzhen Xu, Mingbiao Luo
Summary: Amidoxime is a well-performing uranium adsorption material, but its capability is limited by the presence of other metal ions. Proteins, with their abundant amino and carboxyl groups, possess high selectivity for specific ions and have not been utilized as adsorbents for seawater uranium extraction. In this study, a composite film material (TB@PAO) was fabricated by combining amidoxime and protein to extract uranium from seawater. The simulated seawater experiment showed that TB@PAO had a uranyl adsorption capacity of 11.24 mg center dot g(- 1), which is 4 times that of vanadium adsorption and 7 times that of iron adsorption. The uranyl's adsorption distribution coefficient was 1.5 x 10(5), indicating a high uranyl adsorption affinity of TB@PAO. This work not only provides an adsorbent for seawater uranium extraction but also offers a pathway for designing highly selective seawater uranium extraction materials.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Mahmoud Diab, Thomas Lehmann, Wolfgang Bothe, Payam Akhyari, Stephanie Platzer, Daniel Wendt, Antje-Christin Deppe, Justus Strauch, Stefan Hagel, Albrecht Guenther, Gloria Faerber, Christoph Sponholz, Marcus Franz, Andre Scherag, Ilia Velichkov, Miriam Silaschi, Jens Fassl, Britt Hofmann, Sven Lehmann, Rene Schramm, Georg Fritz, Gabor Szabo, Thorsten Wahlers, Klaus Matschke, Artur Lichtenberg, Mathias W. Pletz, Jan F. Gummert, Friedhelm Beyersdorf, Christian Hagl, Michael A. Borger, Michael Bauer, Frank M. Brunkhorst, Torsten Doenst
Summary: This study investigated the effect of hemoadsorption during cardiac surgery for infective endocarditis (IE) on postoperative organ dysfunction and found that hemoadsorption did not reduce the occurrence of organ dysfunction. Although hemoadsorption reduced cytokine levels during surgery, it did not have an impact on clinically relevant outcome measures.
Article
Instruments & Instrumentation
Shruti S. Sawant, Suyash M. Patil, Snehal K. Shukla, Nishant S. Kulkarni, Vivek Gupta, Nitesh K. Kunda
Summary: Inhalable OB liposomes were developed to limit systemic toxicity and locally accumulate at tumor sites. Active loading of OB into liposomes resulted in higher cytotoxicity and potential for inhibiting lung cancer growth compared to passive loading methods.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Toxicology
Patti C. Zeidler-Erdely, Aaron Erdely, Vamsi Kodali, Ronnee Andrews, James Antonini, Taylor Trainor-DeArmitt, Rebecca Salmen, Lori Battelli, Lindsay Grose, Michael Kashon, Samantha Service, Walter McKinney, Samuel Stone, Lauryn Falcone
Summary: This study characterized copper-nickel fume generated by gas metal arc welding and evaluated its pulmonary deposition and toxicity in mice. The results showed that the fume had high acute lung toxicity in mice.
INHALATION TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Cherie L. DeVore, Lucia Rodriguez-Freire, Noelani Villa, Maedeh Soleimanifar, Jorge Gonzalez-Estrella, Abdul Mehdi S. Ali, Juan Lezama-Pacheco, Carlyle Ducheneaux, Jose M. Cerrato
Summary: We conducted an integrated study combining aqueous chemistry, spectroscopy, and microbiology techniques to investigate the release of arsenic, iron, and manganese from contaminated sediments under different aerobic and anaerobic conditions. Our results showed that the highest concentrations of these metals were released under anaerobic conditions with the addition of an exogenous electron donor. XANES analyses confirmed the reduction of arsenic under anaerobic conditions. Additionally, the release of these metals after a reaction with phosphate was significantly lower compared to experiments amended with glucose.
ACS EARTH AND SPACE CHEMISTRY
(2022)
Article
Toxicology
Vamsi Kodali, Aliakbar Afshari, Terence Meighan, Walter McKinney, Md Habibul Hasan Mazumder, Nairrita Majumder, Jared L. Cumpston, Howard D. Leonard, James B. Cumpston, Sherri Friend, Stephen S. Leonard, Aaron Erdely, Patti C. Zeidler-Erdely, Salik Hussain, Eun Gyung Lee, James M. Antonini
Summary: Thermal spray coating is an industrial process that uses molten metal to create a protective coating on surfaces. In a simulated occupational exposure experiment, it was observed that male rats exposed to stainless steel PMET720 aerosols experienced lung injury, inflammation, and changes in cytokines, which resolved within 7 days. The particles were internalized by alveolar macrophages and their toxicity depended on the dose.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Suyash M. Patil, Nitesh K. Kunda
Summary: D-LAK, a cationic antimicrobial peptide, exhibits strong cytotoxicity against non-small cell lung cancer cell lines, inducing cell apoptosis and arresting the cell cycle, inhibiting cell proliferation and cancer cell migration, and leading to mitochondria-mediated apoptosis. It acts by disrupting the cell membrane.
Article
Toxicology
Nairrita Majumder, Vamsi Kodali, Murugesan Velayutham, Travis Goldsmith, Jessica Amedro, Valery V. Khramtsov, Aaron Erdely, Timothy R. Nurkiewicz, Jack R. Harkema, Eric E. Kelley, Salik Hussain
Summary: Air pollution leads to over 7 million premature deaths worldwide. A study using ultrafine carbon black and ozone as a model found that co-exposure to the mixture resulted in significantly greater lung injury and inflammation compared to individual exposures. The enhanced reactivity of the particles in the mixture was responsible for this increase. Lung tissue gene and protein responses could predict the biological effects.
TOXICOLOGICAL SCIENCES
(2023)
Article
Engineering, Environmental
Isabel Meza, Jorge Gonzalez-Estrella, Peter C. Burns, Virginia Rodriguez, Carmen A. Velasco, Ginger E. Sigmon, Jennifer E. S. Szymanowski, Tori Z. Forbes, Lindsey M. Applegate, Abdul-Mehdi S. Ali, Peter Lichtner, Jose M. Cerrato
Summary: We studied the solubility and thermodynamic properties of two meta-autunite group uranyl arsenate solids. The experiment results showed that the solubility products of NaUAs and KUAs ranged from -23.50 to -22.96 and -23.87 to -23.38, respectively. Secondary phases were identified in the reacted solids, indicating that H3O+ co-occurring with Na or K in the interlayer region can influence the solubilities of uranyl arsenate solids. The standard-state enthalpy of formation from the elements for NaUAs and KUAs is -3025 +/- 22 kJ mol-1 and -3000 +/- 28 kJ mol-1 respectively, consistent with values reported in other studies for uranyl phosphate solids. This work provides important thermodynamic information for understanding the influence of uranyl arsenate solids on soluble concentrations of U and As in contaminated waters.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Physical
Tybur Q. Casuse-Driovinto, Ruben Rizo, Angelica Benavidez, Adrian J. Brearley, Jose M. Cerrato, Fernando H. Garzon, Enrique Herrero, Juan M. Feliu
Summary: The use of highly oriented Au(111) single crystal and thin film surfaces can improve the detection of arsenic (As) in water by reducing the variance in analyte electrode surface adsorption and desorption energies. An ultraflat Au(111) thin film exhibits a similar response to a bulk Au(111) single crystal and can be used to detect trace concentrations of As in water.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Pharmacology & Pharmacy
Suyash M. Patil, Druva Sarika Barji, Sophia Aziz, David A. McChesney, Shapali Bagde, Pavan Muttil, Nitesh K. Kunda
Summary: A dry powder of nisin ZP was formulated using a spray dryer for the treatment of NSCLC. The powder showed irregularly shaped particles with semi-crystalline nature, and it exhibited good stability and suitable particle size for inhalation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Mycology
Taylor A. Portman, Abigail Granath, Michael A. Mann, Eliane El Hayek, Kelsie Herzer, Jose M. Cerrato, Jennifer A. Rudgers
Summary: Characterizing root-associated fungi in mine wastes is important for bioremediation strategies. Ascomycota fungi have both mutualistic associations with plant roots and accumulate heavy metals. Fungal communities in mine sites were less diverse than off-mine sites, and plant growth in mine soils was negatively affected. Identification of candidate fungi for bioremediation and understanding the effects of heavy metals on microbial communities and plant growth are crucial.
Article
Toxicology
Eliane El Hayek, Eliseo Castillo, Julie G. In, Marcus Garcia, Jose Cerrato, Adrian Brearley, Jorge Gonzalez-Estrella, Guy Herbert, Barry Bleske, Angelica Benavidez, Hsuan Hsiao, Lei Yin, Matthew J. Campen, Xiaozhong Yu
Summary: Microplastics are an emerging environmental contaminant with unknown health impacts. UV light is an unavoidable factor for airborne microplastic particles and can modify their chemistry and toxicity. This study found that photoaging altered the surface morphology and increased the toxic potency of irradiated polystyrene microspheres. The aged microspheres exerted more pronounced biological responses in lung cells compared to pristine microspheres, affecting cell cycle, morphology, and barrier integrity.
TOXICOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
K. A. Roach, V. Kodali, M. Shoeb, T. Meighan, M. Kashon, S. Stone, W. McKinney, A. Erdely, P. C. Zeidler-Erdely, J. R. Roberts, J. M. Antonini
Summary: The study examined the effects of multiple exposomal factors on pulmonary inflammation and immune parameters in rats. The results showed that high-fat diet had a greater impact on the immune system of SD rats, while welding fume had a more pronounced effect on immune system recovery in BN rats. These findings highlight the combined impact of genetic, lifestyle, and environmental factors on immune responsivity.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Engineering, Environmental
Jasmine Quiambao, Kendra Z. Hess, Sloane Johnston, Eliane El Hayek, Achraf Noureddine, Abdul-Mehdi S. Ali, Michael Spilde, Adrian Brearley, Peter Lichtner, Jose M. Cerrato, Kerry J. Howe, Jorge Gonzalez-Estrella
Summary: We conducted a study on the co-occurrence of microplastics (MPs) and metals in freshwater environments. The field samples from rural and urban areas in New Mexico showed the presence of MPs and metals, with the urban location having the highest count of confirmed MPs. Laboratory experiments revealed that MPs acted as substrate surfaces for the adsorption and nucleation of uranium (U) precipitates at pH 7. These findings have significant implications for understanding the interaction between MPs and metals in freshwater.
ENVIRONMENTAL ENGINEERING SCIENCE
(2023)
Article
Environmental Sciences
Noah Edward Jemison, Fernando H. Garzon, Stephen E. Cabaniss, Peter C. Lichtner, Angelica Benavidez, Elijah Jessop, Jose M. Cerrato
Summary: This study investigates the charge transfer kinetics of Cr(VI) reduction using electrochemical techniques under laboratory-controlled conditions. The results demonstrate that the addition of copper as an electron shuttle accelerates the reduction rate of Cr(VI), while sulfate, chloride, and organic citrate adsorbed to the electrode surface slow down the reduction rate. The oxidation of certain organics such as ascorbate and cysteine, coupled with the reduction of Cr(VI), increases the reduction rate, while other organics like glutamate and citrate do not undergo electrochemical oxidation.
Article
Engineering, Environmental
Nabil Shaikh, Jiajie Qian, Sewoon Kim, Hoa Phan, Juan S. Lezama-Pacheco, Abdul-Mehdi S. Ali, David M. Cwiertny, Tori Z. Forbes, Amanda J. Haes, Jose M. Cerrato
Summary: Phosphonate functionalized electrospun nanofibers have been found to effectively uptake U(VI), especially when functionalized with longer-chain phosphonate surfactants. The interaction between U(VI) and environmentally relevant ions was investigated, and it was observed that the presence of bicarbonate ions may increase the solubility of uranium. The study also revealed that U is bound to phosphonate groups as a monodentate inner sphere surface complex. This study provides valuable insights for the development of technologies for the detection and treatment of U in water.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)