Article
Nutrition & Dietetics
Barbora Piknova, Ji Won Park, Samantha M. Thomas, Khalid J. Tunau-Spencer, Alan N. Schechter
Summary: Nitric oxide (NO) (co)regulates physiological processes in the body and its availability is affected by aging. Aging leads to changes in nitrate and nitrite contents in tissues, with higher nitrate levels and lower nitrite levels in old rats compared to young rats. However, the nitrate reduction pathway is not affected by aging. Further investigation is needed to understand the changes in NO accessibility during aging.
Article
Pharmacology & Pharmacy
Rose I. M. Batista, Renato C. Nogueira, Graziele C. Ferreira, Gustavo H. Oliveira-Paula, Lucas C. Pinheiro, Jose E. Tanus-Santos
Summary: Supplementation with L-arginine has been shown to have beneficial effects in hypertension by increasing nitric oxide formation and enhancing nitrate concentrations, but these effects may be prevented by antiseptic mouthwash. Alteration of the nitrate cycle in the body by mouthwash can impact endothelial dysfunction, antihypertensive effects, and antioxidant effects of L-arginine in hypertensive rats. The findings suggest a new mechanism where antibacterial mouth rinse can affect arterial blood pressure and the development of cardiovascular diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tijana Suboticki, Olivera Mitrovic Ajtic, Dragoslava Djikic, Marijana Kovacic, Juan F. Santibanez, Milica Tosic, Vladan P. Cokic
Summary: In various systems, hydroxyurea has been shown to stimulate the release of nitric oxide or activate nitric oxide synthase. Through inhibiting nitric oxide metabolites, hydroxyurea is able to inhibit the growth of mature erythroid colonies and impact the presence of iNOS immunoreactive CFU-E.
Review
Pharmacology & Pharmacy
Kayleigh Griffiths, Jordan J. Lee, Michael P. Frenneaux, Martin Feelisch, Melanie Madhani
Summary: Nitric oxide plays a crucial role in protecting the heart from ischemia reperfusion injury through the 'canonical' NO-sGC-cGMP pathway. A new nitrate-nitrite-NO pathway has been discovered to improve endothelial dysfunction, protect the myocardium and reduce infarct size. Nitrite itself also provides multi-faceted protection independent of nitric oxide against various pathophysiologies of IRI.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Food Science & Technology
Raul Bescos, Mark L. Rollason, Tanisha S. Davies, Patricia Casas-Agustench
Summary: This study analyzed the content of nitrate (NO3-) and nitrite (NO2-) in commercial and self-made beetroot juices (BJs), finding that the levels of NO3- can vary with different seasons and storage conditions. The self-made BJ showed complete degradation of NO3- after 3 days at 20 degrees C, but this degradation was attenuated when stored at lower temperatures or with the addition of lemon juice. Additionally, self-made BJs had higher concentrations of NO2- and a higher pH compared to commercial BJs.
FOOD SCIENCE & NUTRITION
(2023)
Article
Cell Biology
Florentin-Daniel Staicu, Analuce Canha-Gouveia, Cristina Soriano-Ubeda, Juan Carlos Martinez-Soto, Evdochia Adoamnei, Jorge E. Chavarro, Carmen Matas
Summary: The levels of nitrite and nitrate in follicular fluid were found to be related to the yield of MII oocytes, and nitrate levels showed a suggestive inverse correlation with embryos with high potential of implantation. This suggests that nitrite and nitrate concentrations in follicular fluid may be useful in predicting ovarian response and embryo implantation potential.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Clinical Neurology
Yicong Wang, Weiqi Chen, Jian Zhou, Yongjun Wang, Hao Wang, Yilong Wang
Summary: This review aims to describe the relationship between nitrate metabolism and cerebrovascular disease, providing a basis for further advances in laboratory and clinical medicine.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Gary D. Miller, Beverly A. Nesbit, Daniel B. Kim-Shapiro, Swati Basu, Michael J. Berry
Summary: This study aimed to investigate the acute response of plasma nitrate and nitrite levels in healthy middle- to older-aged adults to beetroot juice alone and in combination with vitamin C or protein. The results showed no significant differences in plasma nitrate and nitrite levels at 1 h and 3 h after co-ingesting beetroot juice with vitamin C or a whey protein supplement compared to beetroot juice alone.
Article
Physiology
Michaela L. Sundqvist, Jon O. Lundberg, Eddie Weitzberg, Mattias Carlstrom
Summary: The study aimed to investigate potential sex differences in renal nitrate handling during low and high dietary nitrate intake. It was hypothesized that renal clearance and excretion of nitrate are higher in men compared to women. Results showed that women had lower urinary nitrate concentration, amount of nitrate excreted, renal nitrate clearance, and fractional excretion of nitrate compared to men.
Article
Biochemistry & Molecular Biology
Samuel J. Gentle, Khandaker A. Ahmed, Nengjun Yi, Casey D. Morrow, Namasivayam Ambalavanan, Charitharth Lal, Rakesh P. Patel
Summary: The study found that nitrate reductase activity in the oral cavity peaked at 29 weeks' post menstrual age, and infants who developed bronchopulmonary dysplasia (BPD) had significantly lower nitrate reductase activity at this time. The oral microbiota and nitrate reductase activity may play a role in the development of BPD in extremely preterm infants.
Review
Biochemistry & Molecular Biology
Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi
Summary: The lack of beneficial metabolic effects of inorganic NO3- in patients with T2DM may be attributed to species differences in AA metabolism and abnormal AA metabolism in patients with T2DM. Supplementation of AA may be needed for T2DM patients to attain the benefits of inorganic NO3- therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Lauren K. Park, Andrew R. Coggan, Linda R. Peterson
Summary: Despite advances, heart failure with reduced ejection fraction (HFrEF) remains a deadly and disabling disease. Exercise capacity is closely linked to survival in HFrEF patients, and impaired nitric oxide (NO) bioavailability plays a key role in skeletal muscle pathology. Ingestion of inorganic nitrate has shown potential in improving exercise performance for HFrEF patients.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew D. Godwin, Anu Aggarwal, Zachary Hilt, Shalini Shah, Joshua Gorski, Scott J. Cameron
Summary: A diet rich in nitrate may benefit cardiovascular health by increasing platelet NO production, with a more pronounced effect in women compared to men.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Engineering, Environmental
Yujie Wang, Wanqiang Yu, Xiao Li, Jiayuan Yu, Weijia Zhou
Summary: Nitrogenous pollutants have caused serious environmental pollution and pose threats to human life and the ecological environment. The electrochemical reduction of nitrogenous pollutants to ammonia using clean electric energy is considered an ideal technology for their recovery and utilization. Recent advancements in gas diffusion electrodes, catalyst surface enrichment, and tandem catalytic sites have helped overcome limitations such as low solubility, slow mass transfer, low partial current density, and hydrogen production competition. Furthermore, the combination of nitrogenous pollutant reactions with carbon dioxide reduction reactions has expanded their application scope. This review highlights research progress in nitrogenous pollutants reduction, presents challenges and possible future directions, and aims to provide suggestions for industrial application of electrochemical reduction of nitrogenous pollutants.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Plant Sciences
Pradeep Kumar Pathak, Nidhi Yadav, Vemula Chandra Kaladhar, Rekha Jaiswal, Aprajita Kumari, Abir U. Igamberdiev, Gary J. Loake, Kapuganti Jagadis Gupta
Summary: A key feature in the establishment of symbiosis between plants and microbes is the maintenance of the balance between the production and scavenging of nitric oxide (NO). Plant hemoglobins play a central role in scavenging NO and maintaining NO homeostasis. Recent studies have shown that plant hemoglobin 1 is also essential in the establishment and maintenance of plant-bacterial and plant-fungal symbiosis in roots. The classification of plant hemoglobins into symbiotic and non-symbiotic groups is becoming less justified.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)