Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 203, Issue -, Pages 236-243Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2018.05.090
Keywords
Singlet oxygen quantum yield; Photodynamic therapy; Photophysicochemical; Hexadeca-substituted ZnPc
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Funding
- Department of Science and Technology (DST) Innovation and National Research Foundation (NRF), South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [UID 62620]
- Rhodes University
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The syntheses of two zinc(II) phthalocyanines (ZnPcs) having either imidazole (ZnPc 1) or pyridiloxy (ZnPc 2) moieties as their macrocycle substituents are reported. Quaternization of the ZnPcs with methyl iodide afforded water soluble cationic phthalocyanines. The photophysical, photochemical properties and photodynamic therapy (PDT) activity of the ZnPcs were studied in solution. The fluorescence quantum yield and lifetime of ZnPc 1 were higher as compared to ZnPc 2. ZnPc 2 afforded higher triplet state (phi(T)) and singlet oxygen quantum yields (phi(Delta)) in comparison to ZnPc 1. The PDT activity of ZnPcs was investigated against human breast adenocarcinoma cells (MCF-7). The two compounds afforded a very minimal in vitro dark cytotoxicity with 85% viable cells at concentration <= 80 mu M. On irradiation of the cells having the ZnPcs, >= 50% cell death was recorded for ZnPc 1 which was also evidenced by the cells photo -micrograph. (C) 2018 Elsevier B.V. All rights reserved.
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