Characterisation of protein aggregation with the Smoluchowski coagulation approach for use in biopharmaceuticals

The film tells the story: Physical-chemical characteristics of IgG at the liquid-air interface

(2017) Ellen Koepf et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Shipping-Induced Aggregation in Therapeutic Antibodies: Utilization of a Scale-Down Model to Assess Degradation in Monoclonal Antibodies

(2017) Marianna L. Fleischman et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Fate of a Stressed Therapeutic Antibody Tracked by Fluorescence Correlation Spectroscopy: Folded Monomers Survive Aggregation

(2017) Hiroshi Imamura et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Kinetics of Monoclonal Antibody Aggregation from Dilute toward Concentrated Conditions

(2016) Lucrèce Nicoud et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Kinetics of Antibody Aggregation at Neutral pH and Ambient Temperatures Triggered by Temporal Exposure to Acid

(2016) Hiroshi Imamura et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Ron R. Kopito: Unfolding the Secrets of Protein Aggregation

(2016) Ron R. Kopito   TRENDS IN CELL BIOLOGY

Computational Studies of Protein Aggregation: Methods and Applications

(2015) Alex Morriss-Andrews et al.   Annual Review of Physical Chemistry

A multiscale view of therapeutic protein aggregation: A colloid science perspective

(2015) Lucrèce Nicoud et al.   Biotechnology Journal

Gelation of a Monoclonal Antibody at the Silicone Oil–Water Interface and Subsequent Rupture of the Interfacial Gel Results in Aggregation and Particle Formation

(2015) Shyam B. Mehta et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Specific-Ion Effects on the Aggregation Mechanisms and Protein–Protein Interactions for Anti-streptavidin Immunoglobulin Gamma-1

(2015) Gregory V. Barnett et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization

(2015) Thomas Skamris et al.   PHARMACEUTICAL RESEARCH

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

A multiscale view of therapeutic protein aggregation: A colloid science perspective

(2015) Lucrèce Nicoud et al.   Biotechnology Journal

Role of Cosolutes in the Aggregation Kinetics of Monoclonal Antibodies

(2014) Lucrèce Nicoud et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Kinetic Analysis of the Multistep Aggregation Mechanism of Monoclonal Antibodies

(2014) Lucrèce Nicoud et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Simulations of Protein Aggregation: Insights from Atomistic and Coarse-Grained Models

(2014) Alex Morriss-Andrews et al.   Journal of Physical Chemistry Letters

Population Balance Modeling of Aggregation and Coalescence in Colloidal Systems

(2014) Ivan Kryven et al.   MACROMOLECULAR THEORY AND SIMULATIONS

The Role of Electrostatics in Protein–Protein Interactions of a Monoclonal Antibody

(2014) D. Roberts et al.   MOLECULAR PHARMACEUTICS

Therapeutic protein aggregation: mechanisms, design, and control

(2014) Christopher J. Roberts   TRENDS IN BIOTECHNOLOGY

Coarse-Grained Model for Colloidal Protein Interactions, B22, and Protein Cluster Formation

(2013) Marco A. Blanco et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Population Balance Modeling of Antibodies Aggregation Kinetics

(2012) Paolo Arosio et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Importance of the dynamics of adsorption and of a transient interfacial stress on the formation of aggregates of IgG antibodies

(2012) Sergii Rudiuk et al.   Soft Matter

Aggregates in monoclonal antibody manufacturing processes

(2011) María Vázquez-Rey et al.   BIOTECHNOLOGY AND BIOENGINEERING

Coarse-grained models for protein aggregation

(2011) Chun Wu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Predicting solution aggregation rates for therapeutic proteins: Approaches and challenges

(2011) Christopher J. Roberts et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Separation and Characterization of Protein Aggregates and Particles by Field Flow Fractionation

(2009) Shawn Cao et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality

(2008) John F. Carpenter et al.   JOURNAL OF PHARMACEUTICAL SCIENCES