Journal
SMALL
Volume 14, Issue 32, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201801910
Keywords
cell imaging; gold nanoparticles; heat-shock; photothermal; plasmonics
Categories
Funding
- Agence Nationale de la Recherche [ANR-15-CE24-0025-01]
- Agence Nationale de la Recherche et de la Technologie (ANRT) through CIFRE program
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Laser heating of individual cells in culture recently led to seminal studies in cell poration, fusion, migration, or nanosurgery, although measuring the local temperature increase in such experiments remains a challenge. Here, the laser-induced dynamical control of the heat-shock response is demonstrated at the single cell level, enabled by the use of light-absorbing gold nanoparticles as nanosources of heat and a temperature mapping technique based on quadriwave lateral shearing interferometry (QLSI) measurements. As it is label-free, this approach does not suffer from artifacts inherent to previously reported fluorescence-based temperature-mapping techniques and enables the use of any standard fluorescent labels to monitor in parallel the cell's response.
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