Article
Clinical Neurology
Milan Nigam, Smaranda Leu-Semenescu, Isabelle Arnulf
Summary: This case report describes three patients with severe, drug-resistant cataplexy who experienced significant improvement when treated with the anticholinergic muscarinic antagonist tropatepine, with the only side effect being mild mouth dryness. This suggests that tropatepine may provide a new therapeutic option for resistant cataplexy, and supports a role of cholinergic muscarinic transmission in rapid eye movement sleep atonia.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Ying Zhang, Xin Yuan, XiaoHong Yang, XiangQuan Lin, ChunYan Cai, ShiJun Chen, ZhuanZhuan Ai, HuaKun ShangGuan, WenYong Wu, RuiMin Chen
Summary: This study investigated the associations of obesity with growth and puberty in children. The findings showed that children with obesity were taller in early childhood, had earlier onset of puberty, and experienced earlier cessation of growth. However, there was a sex dimorphism on the effect of obesity on the incidence of precocious puberty.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Review
Endocrinology & Metabolism
Li Shi, Zhiyan Jiang, Li Zhang
Summary: This review provides an overview of the impact of childhood obesity on pubertal onset, focusing on signaling pathways and substances associated with obesity, and discusses the potential benefits of preventing obesity and central precocious puberty (CPP) in children, as well as potential strategies for treatment and prevention.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Neurosciences
Vishal Chavda, Bipin Chaurasia, Giuseppe E. Umana, Santino Ottavio Tomasi, Bingwei Lu, Nicola Montemurro
Summary: Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness and brief involuntary sleep episodes. The exact pathophysiology is unknown and differential diagnosis can be challenging. Treatment should be tailored to the patient's symptoms and clinical diagnosis.
Article
Clinical Neurology
Annika Triller, Fabio Pizza, Michel Lecendreux, Lea Lieberich, Rana Rezaei, Anna Pech de Laclause, Stefano Vandi, Giuseppe Plazzi, Ulf Kallweit
Summary: This study evaluated the effects and tolerability of pitolisant treatment in children and adolescents with narcolepsy. The results showed that pitolisant treatment effectively improved excessive daytime sleepiness and cataplexy, and it was well tolerated.
Article
Genetics & Heredity
Taku Miyagawa, Susumu Tanaka, Mihoko Shimada, Noriaki Sakai, Kotomi Tanida, Nozomu Kotorii, Tatayu Kotorii, Yu Ariyoshi, Yuji Hashizume, Kimihiro Ogi, Hiroshi Hiejima, Takashi Kanbayashi, Aya Imanishi, Azusa Ikegami, Yuichi Kamei, Akiko Hida, Yamato Wada, Masayuki Miyamoto, Masanori Takami, Hideaki Kondo, Yoshiyuki Tamura, Yukari Taniyama, Naoto Omata, Tomoyuki Mizuno, Shunpei Moriya, Hirokazu Furuya, Mitsuhiro Kato, Kayoko Kato, Jun Ishigooka, Kazuhito Tsuruta, Shigeru Chiba, Naoto Yamada, Masako Okawa, Koichi Hirata, Kenji Kuroda, Kazuhiko Kume, Naohisa Uchimura, Masaaki Kitada, Tohru Kodama, Yuichi Inoue, Seiji Nishino, Kazuo Mishima, Katsushi Tokunaga, Makoto Honda
Summary: Idiopathic hypersomnia is a rare sleep disorder characterized by excessive daytime sleepiness. A study in a Japanese population identified a rare variant associated with this disorder, which results in decreased signaling through orexin receptors, similar to narcolepsy type 1.
NPJ GENOMIC MEDICINE
(2022)
Article
Clinical Neurology
Lucie Barateau, Michel Lecendreux, Sofiene Chenini, Anna Laura Rassu, Regis Lopez, Carole Pesenti, Isabelle Jaussent, Severine Beziat, Yves Dauvilliers
Summary: The study validated the Narcolepsy Severity Scale (NSS) in adults with narcolepsy type 1 (NT1) and developed the Pediatric NSS (NSS-P). Through a survey of 209 children and adolescents, it was found that NSS-P has good psychometric properties and reliability in pediatric NT1 patients.
Article
Biochemistry & Molecular Biology
Qiuyun Gu, Xiaodi Wang, Luyao Xie, Xinyuan Yao, Linxi Qian, Zhiping Yu, Xiuhua Shen
Summary: This study aimed to investigate the potential regulatory pathways of EGCG in preventing obesity-related precocious puberty. The results showed that EGCG could prevent precocious puberty through the NKB/NK3R signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Clinical Neurology
Ye Zhang, Rong Ren, Linghui Yang, Haipeng Zhang, Yuan Shi, Larry D. Sanford, Xiangdong Tang
Summary: A systematic review of polysomnographic studies comparing narcolepsy patients with healthy controls revealed significant differences in various sleep parameters. Narcolepsy type 1 patients showed more disrupted nighttime sleep, while children and adolescents with narcolepsy displayed differences in nighttime sleep compared to adults. Various demographic and clinical factors contribute to heterogeneity in study findings.
SLEEP MEDICINE REVIEWS
(2021)
Article
Clinical Neurology
Claudio L. A. Bassetti, Ulf Kallweit, Luca Vignatelli, Giuseppe Plazzi, Michel Lecendreux, Elisa Baldin, Leja Dolenc-Groselj, Poul Jennum, Ramin Khatami, Mauro Manconi, Geert Mayer, Markku Partinen, Thomas Pollmaecher, Paul Reading, Joan Santamaria, Karel Sonka, Yves Dauvilliers, Gert J. Lammers
Summary: This paper provides evidence-based guidelines for the management of narcolepsy in adults and children, with main recommendations focusing on treatment options for excessive daytime sleepiness and cataplexy, tailored to each patient's individual circumstances.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Endocrinology & Metabolism
Sara Prosperi, Francesco Chiarelli
Summary: During the COVID-19 pandemic, the implementation of strict measures like lockdowns and school closures caused significant disruptions in the lives of children and adolescents, leading to a sedentary lifestyle, increased use of electronic devices, and higher levels of stress-related symptoms. Studies have reported an increase in early and precocious puberty cases during this period, suggesting a potential role of environmental and lifestyle factors in triggering earlier pubertal onset. It is important to further investigate the exact impact of COVID-19 on pubertal development through global studies and long-term research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Maria Elisabeth Street, Davide Ponzi, Roberta Renati, Maddalena Petraroli, Tiziana D'Alvano, Claudia Lattanzi, Vittorio Ferrari, Dolores Rollo, Stefano Stagi
Summary: Neuro-biological variations in sexual maturation timing are evolutionary strategies influenced by internal and external environmental conditions. Central precocious puberty (CPP) has increased among adopted and COVID-19 pandemic children. Previously, it was believed that better nutrition, environmental stability, and psychological wellbeing contributed to CPP in adopted children. However, data collected during the pandemic suggests other factors related to fear and stress may also trigger early puberty. This review investigates the neurobiological and evolutionary mechanisms of puberty, analyzing the similarities between CPP during the pandemic and in adopted children to identify potential triggers, particularly stress-related activation of the hypothalamic-pituitary-gonadal axis and its correlation with rapid sexual maturation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Gaiyan Liu, Jinxin Guo, Xuejing Zhang, Yu Lu, Junjie Miao, Hongmei Xue
Summary: The study found that prolonged overweight and obesity in early childhood may be risk factors for CPP, especially in girls. This suggests that weight loss might be an important approach for the prevention of precocious puberty in children.
Article
Endocrinology & Metabolism
Yawen Zhang, Jianmin Ni, Lei Zhang, Tingting Yu, Xiaoqing Li, Peng Xue, Yifan Liu, Bo Gao, Xinwen Xue, Huijun Kong, Shijian Liu
Summary: In Qufu, Shandong Province, China, the prevalence of precocious puberty is high, and overweight and obesity are related to precocious puberty.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Qiuyun Gu, Lina Xia, Qiuju Du, Ying Shao, Jieyi He, Peiying Wu, Lingwei Liang, Xiuhua Shen
Summary: Objective: This study aimed to explore the mechanism of epigallocatechin-3-gallate (EGCG) in preventing obesity-related precocious puberty through the integration of metabolomics and network pharmacology. Results: The serum metabolomics analysis revealed 234 differential metabolites, while the network pharmacology predicted 153 common targets. These targets and metabolites were mainly involved in endocrine-related pathways and signal transduction pathways. Key targets identified for EGCG in preventing obesity-related precocious puberty were AKT1, EGFR, ESR1, STAT3, IGF1, and MAPK1. Conclusion: EGCG may prevent obesity-related precocious puberty through its effects on these targets and multiple signaling pathways.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Ilona Merikanto, Laura Kortesoja, Christian Benedict, Frances Chung, Jonathan Cedernaes, Colin A. Espie, Charles M. Morin, Yves Dauvilliers, Markku Partinen, Luigi De Gennaro, Yun Kwok Wing, Ngan Yin Chan, Yuichi Inoue, Kentaro Matsui, Brigitte Holzinger, Giuseppe Plazzi, Sergio Arthuro Mota-Rolim, Damien Leger, Thomas Penzel, Bjorn Bjorvatn
Summary: During the COVID-19 pandemic, evening-types experienced poorer mental health, well-being, and quality of life compared to other circadian types. They also reported delayed sleep-wake schedules, increased sleep duration, and more severe sleep problems. Meanwhile, morning-types were less vulnerable to sleep changes and experienced protection from most sleep problems.
Article
Neurosciences
Elena Antelmi, Lorenzo Rocchi, Anna Latorre, Daniele Belvisi, Francesca Magrinelli, Kailash P. Bhatia, Michele Tinazzi
Summary: Although restless legs syndrome (RLS) is a common neurological disorder, it is poorly understood from a clinical and pathophysiological perspective. However, based on several lines of evidence, it is proposed that RLS should be seen as a disorder of sensorimotor interaction with a typical circadian pattern of occurrence.
Correction
Clinical Neurology
Yves Dauvilliers, Karel Sonka, Richard K. Bogan, Markku Partinen, Rafael Del Rio Villegas, Nancy Foldvary-Schaefer, Roman Skowronski, Abby Chen, Jed Black, Franck Skobieranda, Michael J. Thorpy
Review
Clinical Neurology
Fabio Pizza, Lucie Barateau, Yves Dauvilliers, Giuseppe Plazzi
Summary: The orexins, or hypocretins, are neuropeptides produced by neurons in the lateral hypothalamus and play a role in regulating sleep, wakefulness, and other functions. Destruction of orexin neurons leads to narcolepsy in humans, and impairments in orexin signaling cause narcoleptic-like symptoms in animals. The discovery of orexins has revolutionized sleep research and holds promise for therapeutic applications in various fields.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Lucie Barateau, Sofiene Chenini, Anna Laura Rassu, Claire Denis, Quentin Lorber, Cloe Dhalluin, Regis Lopez, Isabelle Jaussent, Severine Beziat, Yves Dauvilliers
Summary: During the COVID-19 lockdown, patients with narcolepsy and idiopathic hypersomnia extended their sleep duration, while patients with restless legs syndrome did not. These changes had negative consequences on their quality of life.
Article
Clinical Neurology
Ilona Merikanto, Yves Dauvilliers, Frances Chung, Yun Kwok Wing, Luigi De Gennaro, Brigitte Holzinger, Bjorn Bjorvatn, Charles M. Morin, Thomas Penzel, Christian Benedict, Adrijana Koscec Bjelajac, Ngan Yin Chan, Colin A. Espie, Harald Hrubos-Strom, Yuichi Inoue, Maria Korman, Anne-Marie Landtblom, Damien Leger, Kentaro Matsui, Sergio Mota-Rolim, Michael R. Nadorff, Giuseppe Plazzi, Catia Reis, Juliana Yordanova, Markku Partinen
Summary: An international survey study reveals that post-acute sequelae of COVID-19 symptoms are more prevalent among severe cases and long-lasting sleep problems are at the core of these symptoms. Understanding the importance of sleep-related symptoms has clinical relevance in diagnosing and treating long-COVID.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Regis Lopez, Lucie Barateau, Sofiene Chenini, Anna Laura Rassu, Yves Dauvilliers
Summary: This study evaluated the feasibility, acceptability, and usefulness of home nocturnal infrared video recording in assessing the frequency and complexity of non-rapid eye movement sleep parasomnias in adults, as well as monitoring treatment response.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Regis Lopez, Lucie Barateau, Anna Laura Rassu, Elisa Evangelista, Sofiene Chenini, Sabine Scholz, Isabelle Jaussent, Yves Dauvilliers
Summary: The study aims to evaluate alternative measures of the multiple sleep latency test (MSLT) for identifying hypocretin-deficiency in patients with hypersomnolence, including narcolepsy patients. The results show that compared to the current neurophysiological standard criteria, alternative MSLT measures are more effective in identifying hypocretin-deficient patients with hypersomnolence and narcolepsy. Daytime REM sleep duration is highlighted as a relevant neurophysiological biomarker of hypocretin-deficiency, which can be used in clinical and research settings.
Article
Medicine, General & Internal
Francois Bughin, Helene Kovacsik, Isabelle Jaussent, Kamila Solecki, Sylvain Aguilhon, Juliette Vanoverschelde, Hamid Zarqane, Jacques Mercier, Fares Gouzi, Francois Roubille, Yves Dauvilliers
Summary: This study aimed to investigate the impact of obstructive sleep apnea syndrome (OSA) on ventricular remodeling post-acute myocardial infarction (AMI). The results showed no association between OSA and ventricular remodeling in patients with moderate to severe AMI. These findings highlight the complexity of the relationship between OSA and post-AMI morbi-mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Dieter Kunz, Yves Dauvilliers, Heike Benes, Diego Garcia-Borreguero, Giuseppe Plazzi, Dalma Seboek Kinter, Preciosa Coloma, Magdalene Rausch, Mouna Sassi-Sayadi, Stephen Thein
Summary: In this 40-week extension study, Daridorexant was found to be safe and well-tolerated for long-term treatment of insomnia disorder. It improved sleep and daytime functioning, with the most pronounced effects observed with the 50 mg dose.
Article
Clinical Neurology
Marie-Laure Ancelin, Isabelle Jaussent, Karen Ritchie, Alain Besset, Joanne Ryan, Yves Dauvilliers
Summary: This study examines the association between BDNF variants and promoter I methylation with sleep disturbances in older adults. The results show that wake time after sleep onset (WASO) is associated with four SNPs in participants not taking psychotropic drugs, while the associations are either not significant or in the reverse direction in participants taking drugs. Higher BDNF methylation levels are found in participants with long WASO, and this varies depending on psychotropic drug use.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Sofiene Chenini, Lucie Barateau, Lily Guiraud, Marie-Lou Rollin, Regis Lopez, Isabelle Jaussent, Severine Beziat, Yves Dauvilliers
Summary: One-third of patients with restless legs syndrome reported a decrease in symptoms during cognitive activities, and this improvement was confirmed during a sustained cognitive task.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Yves Dauvilliers, Thomas Roth, Richard Bogan, Michael J. Thorpy, Anne Marie Morse, Asim Roy, Jordan Dubow, Jennifer Gudeman
Summary: This study evaluated the efficacy of extended-release once-nightly sodium oxybate (ON-SXB; FT218) compared to placebo for daytime sleepiness and disrupted nighttime sleep in narcolepsy type 1 (NT1) and 2 (NT2). The results showed significant improvements in sleep latency, sleep quality, nocturnal arousals, and daytime sleepiness for both NT1 and NT2 subgroups treated with ON-SXB compared to placebo.
Article
Clinical Neurology
Tobias Di Marco, Thomas E. Scammell, Michael Meinel, Dalma Seboek Kinter, Alexandre N. Datta, Gary Zammit, Yves Dauvilliers
Summary: The study aimed to explore the effect of daridorexant, a dual orexin receptor antagonist, on nighttime wake bouts and their correlation with daytime functioning. Results showed that daridorexant reduced the number and duration of long wake bouts during the night compared with placebo, corresponding with improved daytime functioning.
Review
Immunology
Roland S. Liblau, Daniela Latorre, Birgitte R. Kornum, Yves Dauvilliers, Emmanuel J. Mignot
Summary: Narcolepsy type 1 (NT1) is a chronic sleep disorder caused by the loss of certain hypothalamic neurons. It is suspected to have an immune-mediated basis, supported by genetic evidence and increased incidence after vaccination. The search for antigens recognized by pathogenic T cell response in NT1 is ongoing, and animal models provide insights into the roles of autoreactive T cells.
NATURE REVIEWS IMMUNOLOGY
(2023)