Article
Oncology
Chunmeng Wei, Xi Chen, Jin Ji, Yalong Xu, Xing He, Huiyong Zhang, Zengnan Mo, Fubo Wang
Summary: The study evaluated the performance of urinary exosomal prostate-specific antigen (UE-PSA) in predicting the results of initial prostate biopsies and distinguishing clinically significant prostate cancer. The results showed that UE-PSA had high accuracy and clinical value in predicting and distinguishing prostate cancer, making it a promising noninvasive biomarker to improve prostate cancer detection.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Jiahua Gan, Xing Zeng, Xiong Wang, Ya Wu, Ping Lei, Zhihua Wang, Chunguang Yang, Zhiquan Hu
Summary: This study evaluated the diagnostic value of candidate genes (ERG, PCA3, ARV7, PSMA, CK19, and EpCAM) in urinary exosomes. The results showed that the expression of these genes in urinary exosomes was significantly increased in patients with prostate cancer and was closely correlated with the Gleason score. Receiver operating characteristic curves demonstrated that these genes in urinary exosomes could distinguish patients with prostate cancer from healthy individuals.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yiwu Yan, Su Yeon Yeon, Chen Qian, Sungyong You, Wei Yang
Summary: Prostate cancer is a leading cause of morbidity and mortality among men worldwide, and advancements in multiple protein biomarkers offer hope for its diagnosis and prognosis. The identification of multi-protein biomarkers with high sensitivity and specificity, as well as their integration with clinicopathologic parameters, imaging, and other molecular biomarkers, can help achieve optimal personalized management for PC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jitian Li, Bo Qin, Manyu Huang, Yan Ma, Dongsheng Li, Wuyin Li, Zhiping Guo
Summary: Osteosarcoma is the most common malignant bone tumor in childhood and adolescence, with a poor prognosis. Anti-tumor-associated antigens autoantibodies in sera may serve as serological biomarkers for early cancer detection and provide new insights into the molecular and cellular biology of cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Jianhua Jiao, Jingliang Zhang, Zeyu Li, Weihong Wen, Chaochao Cui, Qiang Zhang, Jing Wang, Weijun Qin
Summary: PSMA PET is an excellent molecular imaging technique that can improve the detection rate and staging accuracy of prostate cancer, providing more appropriate treatment for primary prostate cancer. PSMA PET has the potential to become the preferred imaging modality and has other potential applications.
Article
Oncology
Danielle S. Bitterman, Ming-Hui Chen, Jing Wu, Andrew A. Renshaw, Marian Loffredo, Philip W. Kantoff, Eric J. Small, Anthony V. D'Amico
Summary: This study found that low testosterone level at PSA failure in high-risk patients with PC treated with RT is associated with increased PCSM and ACM risk, and that higher PSAn is also associated with worse PCSM and ACM risk, especially in men with normal testosterone levels at PSA failure.
Article
Oncology
Muhammad Bilal, Aqsa Javaid, Farhat Amjad, Tamer Abou Youssif, Samia Afzal
Summary: Prostate cancer is a common cancer among men worldwide. The current screening methods include digital rectal examination, prostate-specific antigen (PSA) testing, and biopsies. Recent research suggests that miRNAs could serve as non-invasive biomarkers for diagnosis, prognosis, and prediction in prostate cancer. Combining miRNA analysis with other tests can help guide personalized treatment and reduce unnecessary biopsies.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Jae-Uk Jeong, Taek-Keun Nam, Ju-Young Song, Mee Sun Yoon, Sung-Ja Ahn, Woong-Ki Chung, Ick Joon Cho, Yong-Hyub Kim, Shin Haeng Cho, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon
Summary: In patients with locally advanced prostate cancer, the addition of long-term A-ADT over 1 year to radiotherapy leads to favorable biochemical failure-free survival and overall survival rates. Achieving a nadir PSA value <= 0.001 ng/mL is a strong clinical predictor of treatment outcomes for prostate cancer patients receiving combination therapy with radiotherapy and A-ADT.
Article
Cell Biology
Qiang Chen, Xiaorong Yang, Binbin Gong, Wenjie Xie, Ming Ma, Shengqiang Fu, Siyuan Wang, Yutang Liu, Zhicheng Zhang, Ting Sun, Zhilong Li
Summary: The study revealed that SNHG10 is overexpressed in prostate cancer and is associated with advanced clinical parameters, showing significant diagnostic ability. SNHG10 expression is also correlated with oxidative phosphorylation and immune infiltrated cells, affecting cell proliferation, migration, and invasion of PC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Analytical
Canan Ozyurt, Inci UludaG, Bahar Ince, Mustafa Kemal Sezginturk
Summary: PSA, as a marker of prostate cancer, has been extensively studied and updated in analysis methods due to advancements in biosensing technology. The increasing number of PSA biosensors in the biomedical sector demonstrates high sensitivity, selectivity, and specificity. Different recognition elements and transducers are being used to enhance PSA detection methods.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Oncology
Chia-Yang Li, Shu-Pin Huang, Yei-Tsung Chen, Hsin-En Wu, Wei-Chung Cheng, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Jiun-Hung Geng, Te-Ling Lu, Bo-Ying Bao
Summary: This study suggests that immunodeficiency pathway-related genes, particularly TNFRSF13B, may play a potential role in the progression of prostate cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Susann Allelein, Keshia Aerchlimann, Gundula Roesch, Roxana Khajehamiri, Andreas Koelsch, Christian Freese, Dirk Kuhlmeier
Summary: Prostate cancer is the second most common cancer in men, which can be successfully treated when detected early. Communication between cells is done through the release of EVs, and specific isolation of EVs from urine can improve their surface markers and have potential clinical value.
Article
Chemistry, Multidisciplinary
Thakshila Liyanage, Bayan Alharbi, Linh Quan, Aurora Esquela-Kerscher, Gymama Slaughter
Summary: A tapered optical fiber plasmonic biosensor was developed for the sensitive detection of a panel of microRNAs in human serum. This biosensor showed high sensitivity and selectivity, enabling cancer diagnosis without the need for RNA extraction or sample amplification. Statistical studies demonstrated its reliable ability to differentiate cancerous and noncancerous samples.
Article
Medicine, General & Internal
Ivo Vujicic, Aleksandar Rusevski, Oliver Stankov, Zivko Popov, Aleksandar Dimovski, Katarina Davalieva
Summary: Currently available tests for prostate cancer clinical management are not accurate enough, and there is a clinical need to identify new molecular markers. This study collected and evaluated candidate biomarkers from published proteomic comparative studies of prostate tissue. FABP5 and ENO1 showed significant differences in protein levels between prostate cancer and benign prostatic hyperplasia (BPH). Combining FABP5, ENO1, and PSA provided the highest accuracy for prostate cancer detection. Additionally, AZGP1, FABP5, and EZR showed correlation with prognosis and clinical characteristics of prostate cancer. This study opens a way for further testing high-quality proteomic biomarkers, which could ultimately add value to the clinical management of prostate cancer.
Article
Oncology
Vasiliki Spyratou, Eva Freyhult, Anders Bergh, Camilla Thellenberg-Karlsson, Pernilla Wikstrom, Karin Welen, Andreas Josefsson
Summary: This study investigates the potential of PSA and Ki67 immunoreactive scores as prognostic and treatment-predictive markers for metastatic hormone naive prostate cancer patients. The results show that PSA immunohistochemical score is the strongest prognostic factor for progression-free and overall survival after ADT. Furthermore, a high Ki67/PSA ratio is associated with cell-cycle regulation and DNA damage repair.
Review
Biochemistry & Molecular Biology
Olga A. Zhunina, Nikita G. Yabbarov, Andrey V. Grechko, Antonina V. Starodubova, Ekaterina Ivanova, Nikita G. Nikiforov, Alexander N. Orekhov
Summary: Mitochondrial dysfunction is closely associated with various human pathologies, with ROS and RNS playing a critical role in causing protein and mtDNA damage and leading to the development of diseases. Recent studies have identified numerous mtDNA mutations linked to different human pathologies, each having distinct effects in disease progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Dwaipayan Bharadwaj, Gauri Prasad, Andrey Grechko, Margarita A. Sazonova, Alexander N. Orekhov
Summary: Atherosclerosis has a complex pathogenesis involving inflammation, lipid metabolism alterations, and endothelial injury. The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in the inflammatory response regulation, making it a promising target for atherosclerosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Valentina Alfieri, Veronika A. Myasoedova, Maria Cristina Vinci, Maurizio Rondinelli, Paola Songia, Ilaria Massaiu, Nicola Cosentino, Donato Moschetta, Vincenza Valerio, Michele Ciccarelli, Giancarlo Marenzi, Stefano Genovese, Paolo Poggio
Summary: Glycemic variability (GV) is closely associated with cardiovascular diseases in diabetes mellitus (DM) patients, leading to worse cardiovascular outcomes. Standardized assessment of GV and clinical trials aiming to improve diagnostic and prognostic accuracy are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ilaria Massaiu, Paola Songia, Mattia Chiesa, Vincenza Valerio, Donato Moschetta, Valentina Alfieri, Veronika A. Myasoedova, Michael Schmid, Luca Cassetta, Gualtiero Colombo, Yuri D'Alessandra, Paolo Poggio
Summary: Transcript sequencing is essential in understanding biological processes in diagnostic and clinical medicine. Long-read sequencing technologies, like those offered by Oxford Nanopore Technologies, can overcome limitations of short-read RNA-Seq approaches and provide improved sensitivity for identifying genes and their expression levels, particularly for non-coding genes. The study demonstrated the ability to achieve desired accuracy levels by sequencing a certain number of reads through the ONT MinION platform for human cell RNA studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anesthesiology
Valery Likhvantsev, Giovanni Landoni, Sergey Perekhodov, Nikolay Chaus, Kristina Kadantseva, Lyubov Ermokhina, Anastasia Baeva, Mikhail Yadgarov, Levan Berikashvili, Artem Kuzovlev, Andrey Grechko
Summary: This study aimed to identify predictors of poor quality of life in COVID-19 ICU survivors. The researchers found that treatment with low-molecular-weight heparin was associated with improved physical component of quality of life, while older age and female sex were associated with a decrease in the physical component. Patients with a medical history of cerebrovascular insufficiency had a decrease in the mental component, while a higher body mass index was associated with an increase in the mental health component.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: Cardiovascular diseases are a major cause of death worldwide, with molecular chaperones like HSP90 playing a crucial role in heart protection and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Anastasiya S. Babkina, Irina V. Ostrova, Mikhail Ya Yadgarov, Artem N. Kuzovlev, Andrey V. Grechko, Alexey V. Volkov, Arkady M. Golubev
Summary: Increased plasma levels of VWF in COVID-19 patients are associated with thrombus formation. Duration of disease and thrombotic complications are independent predictors of increased VWF immunostaining in pulmonary vessels. Additionally, bacterial pneumonia and lung ventilation are also associated with increased VWF staining.
Article
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Andrey V. Grechko, Nikolay K. Shakhpazyan, Alexander N. Orekhov
Summary: KLF2 is a crucial factor in regulating atheroprotective effects in endothelial cells, preventing the development and progression of atherosclerosis. Recently, repurposed drugs and natural compounds targeting KLF2 have been identified, showing potential for treating atherosclerosis.
Article
Biochemistry & Molecular Biology
Donato Moschetta, Enrico Di Maria, Vincenza Valerio, Ilaria Massaiu, Michele Bozzi, Paola Songia, Yuri D'alessandra, Veronika A. Myasoedova, Paolo Poggio
Summary: This study found that P2RY2 activation can inhibit fibro-calcific remodeling in CAVS, reducing cellular calcification and decreasing the expression of fibrotic genes and alpha-smooth muscle actin.
Review
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Evgeny E. Bezsonov, Evgeny E. Borisov, Andrey V. Grechko, Andrey G. Kartuesov, Alexander N. Orekhov
Summary: HIV is one of the biggest global health problems, but modern antiretroviral therapy has improved patients' ability to manage the disease. Atherosclerosis, on the other hand, lacks an effective treatment. Understanding the characteristics of atherosclerosis development in HIV carriers is of great scientific interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alexander V. Blagov, Andrey V. Grechko, Nikita G. Nikiforov, Evgeny E. Borisov, Nikolay K. Sadykhov, Alexander N. Orekhov
Summary: Mitochondrial dysfunction is recognized as a contributor to neurodegenerative diseases, including Alzheimer's disease. The accurate dynamics of mitochondria are crucial for their complex functions, and disruption of these dynamics may play a key role in the pathogenesis of AD. Improving mitochondrial dynamics and function could provide an alternative treatment approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuri D'Alessandra, Vincenza Valerio, Donato Moschetta, Ilaria Massaiu, Michele Bozzi, Maddalena Conte, Valentina Parisi, Michele Ciccarelli, Dario Leosco, Veronika A. Myasoedova, Paolo Poggio
Summary: In this study, a new method for the detection of circulating miRNAs was evaluated. It involves sample lysis followed by direct evaluation using dPCR, without the need for RNA extraction. The results showed that dPCR can accurately detect low-copy-number and highly expressed miRNAs in plasma samples.
Article
Biochemistry & Molecular Biology
Ilaria Massaiu, Jeness Campodonico, Massimo Mapelli, Elisabetta Salvioni, Vincenza Valerio, Donato Moschetta, Veronika A. Myasoedova, Maria Domenica Cappellini, Giulio Pompilio, Paolo Poggio, Piergiuseppe Agostoni
Summary: By analyzing the gene expression profiles of iron-linked genes at the tissue and single-cell level in heart failure patients, it was found that the iron metabolism in cardiomyocytes is altered, including imbalanced iron ion internalization, decreased internal conversion, increased hemoglobin synthesis, elevated heme externalization, reduced heme cleavage, and up-regulated hepcidin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Nikita G. Nikiforov, Alexander D. Zhuravlev, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: This review focuses on the roles of mitochondrial metabolism, ROS production, mitochondrial dynamics, and mitophagy in normal aging and pathological conditions. It also discusses the impact of inflammaging on neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Igor A. Sobenin, Alexander M. Markin, Victor Y. Glanz, Yuliya Markina, Wei-Kai Wu, Veronika A. Myasoedova, Alexander N. Orekhov
Summary: The most typical feature of atherogenesis in humans is the formation of foam cells, mainly sourced from circulating LDL, which must undergo proatherogenic modification to acquire atherogenic properties.
CURRENT MEDICINAL CHEMISTRY
(2021)
