A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells

Positive Feedback Mechanisms among Local Ca Releases, NCX, and I CaL Ignite Pacemaker Action Potentials

(2018) Alexey E. Lyashkov et al.   BIOPHYSICAL JOURNAL

Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells

(2017) Alexander V. Maltsev et al.   PLoS One

Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells

(2016) Syevda G. Sirenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Small-conductance Ca2+-activated K+ channels and cardiac arrhythmias

(2015) Xiao-Dong Zhang et al.   HEART RHYTHM

Sick sinus syndrome and atrial fibrillation in older persons — A view from the sinoatrial nodal myocyte

(2015) O. Monfredi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction

(2015) Thomas A. Csepe et al.   Frontiers in Physiology

The importance of Ca2+-dependent mechanisms for the initiation of the heartbeat

(2015) Rebecca A. Capel et al.   Frontiers in Physiology

BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo

(2014) Michael H. Lai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Modern Perspectives on Numerical Modeling of Cardiac Pacemaker Cell

(2014) Victor A. Maltsev et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: Relevance to arrhythmias and bio-pacemaker design

(2013) Syevda Sirenko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Modern Concepts Concerning the Origin of the Heartbeat

(2013) Oliver Monfredi et al.   PHYSIOLOGY

Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells

(2013) Oliver Monfredi et al.   PLoS One

SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells

(2013) D. Weisbrod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+-Dependent Phosphorylation of Ca2+ Cycling Proteins Generates Robust Rhythmic Local Ca2+ Releases in Cardiac Pacemaker Cells

(2013) S. Sirenko et al.   Science Signaling

Calcium Transient and Sodium-Calcium Exchange Current in Human versus Rabbit Sinoatrial Node Pacemaker Cells

(2013) Arie O. Verkerk et al.   TheScientificWorldJOURNAL

Is sodium current present in human sinoatrial node cells?

(2012) Arie O. Verkerk et al.   International Journal of Biological Sciences

A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker

(2010) Edward G. Lakatta et al.   CIRCULATION RESEARCH

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model

(2009) Victor A. Maltsev et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

What keeps us ticking: a funny current, a calcium clock, or both?

(2009) Edward G. Lakatta et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY