Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells

L-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+release during sino-atrial node pacemaker activity

(2016) Angelo Giovanni Torrente et al.   CARDIOVASCULAR RESEARCH

Automated Detection and Analysis of Ca2+ Sparks in x-y Image Stacks Using a Thresholding Algorithm Implemented within the Open-Source Image Analysis Platform ImageJ

(2014) Elliot M. Steele et al.   BIOPHYSICAL JOURNAL

Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells

(2014) Michael D. Stern et al.   JOURNAL OF GENERAL PHYSIOLOGY

RyR-NCX-SERCA Local Cross-Talk Ensures Pacemaker Cell Function at Rest and During the Fight-or-Flight Reflex

(2013) Anna V. Maltsev et al.   CIRCULATION RESEARCH

Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: Relevance to arrhythmias and bio-pacemaker design

(2013) Syevda Sirenko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells

(2013) Oliver Monfredi et al.   PLoS One

A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker

(2010) Edward G. Lakatta et al.   CIRCULATION RESEARCH

Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model

(2009) Victor A. Maltsev et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca2+ cycling and IKACh

(2009) Alexey E. Lyashkov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Local control of Ca2+-induced Ca2+ release in mouse sinoatrial node cells

(2009) Biyi Chen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calcium Sparks

(2008) Heping Cheng et al.   PHYSIOLOGICAL REVIEWS